Clonidine HCl MBT vs. Placebo to Prevent Chemoradiotherapy-Induced Severe Oral Mucositis in Oropharyngeal Cancer.
Public ClinicalTrials.gov record NCT04648020. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b/3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Clonidine Mucoadhesive Buccal Tablet to Placebo to Prevent Chemoradiotherapy-induced Severe Oral Mucositis in Patients With Oropharyngeal Cancer
Study identification
- NCT ID
- NCT04648020
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Monopar Therapeutics
- Industry
- Enrollment
- 190 participants
Conditions and interventions
Interventions
- Clonidine HCl Mucoadhesive Buccal Tablet Drug
- Placebo Mucoadhesive Buccal Tablet Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 10, 2021
- Primary completion
- May 13, 2023
- Completion
- May 13, 2023
- Last update posted
- May 30, 2023
2021 – 2023
United States locations
- U.S. sites
- 48
- U.S. states
- 25
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Orange Coast Memorial Medical Center | Fountain Valley | California | 92708 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Grand Valley Oncology | Grand Junction | Colorado | 81505 | — |
| Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| Memorial Healthcare System | Pembroke Pines | Florida | 33028 | — |
| University Cancer & Blood Center | Athens | Georgia | 30607 | — |
| IACT Health (Centricity Research) | Columbus | Georgia | 31904 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Edward Elmhurst Health | Elmhurst | Illinois | 60126 | — |
| NorthShore University Health Systems | Evanston | Illinois | 60201 | — |
| AMITA Health | Hinsdale | Illinois | 60521 | — |
| UnityPoint Health | Cedar Rapids | Iowa | 52403 | — |
| Des Moines Oncology Research Association | Des Moines | Iowa | 50309 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| Louisiana State University Health - Shreveport | Shreveport | Louisiana | 71103 | — |
| Willis-Knighton Cancer Center | Shreveport | Louisiana | 71103 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Cox Medical Centers | Springfield | Missouri | 65807 | — |
| Summit Health | Florham Park | New Jersey | 07932 | — |
| New York Cancer and Blood Specialists | New York | New York | 10028 | — |
| Northwell Health | New York | New York | 11042 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Novant Health Cancer Institute | Charlotte | North Carolina | 28204 | — |
| CaroMont Regional Medical Center | Gastonia | North Carolina | 28054 | — |
| Novant Health Cancer Institute - Forsyth | Winston-Salem | North Carolina | 27103 | — |
| Summa Health System | Akron | Ohio | 44304 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Mercy Health | Youngstown | Ohio | 44501 | — |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Cancer Specialists | Tulsa | Oklahoma | 74146 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| AHN Cancer Institute - Allegheny General | Pittsburgh | Pennsylvania | 15212 | — |
| Mary Hillman Radiation Oncology Center at UPMC Shadyside | Pittsburgh | Pennsylvania | 15232 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Charleston Oncology | Charleston | South Carolina | 29406 | — |
| Ballad Health | Johnson City | Tennessee | 37604 | — |
| Hendrick Cancer Center | Abilene | Texas | 79601 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23507 | — |
| PeaceHealth | Bellingham | Washington | 98225 | — |
| Providence Regional Cancer Partnership | Everett | Washington | 98201 | — |
| Benaroya Research Institute at Virginia Mason | Seattle | Washington | 98101 | — |
| HSHS St. Vincent Hospital Cancer Centers at HSHS St. Vincent Hospital | Green Bay | Wisconsin | 54301 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04648020, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 30, 2023 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04648020 live on ClinicalTrials.gov.