A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19
Public ClinicalTrials.gov record NCT04649151. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3, Randomized, Observer-Blind, Placebo-Controlled Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 SARS-CoV-2 Vaccine in Healthy Adolescents 12 to <18 Years of Age
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The mRNA-1273 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection. The study is designed to primarily evaluate the safety, reactogenicity, and effectiveness of mRNA-1273 vaccine administered as primary series and a booster dose (BD) to an adolescent population. The study will also evaluate the safety and immunogenicity of an mRNA-1273.222 vaccine against the SARS-CoV- 2 omicron variant as a primary series.
Study identification
- NCT ID
- NCT04649151
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 4,328 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years to 18 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2020 (Actual)
- Primary completion
- Jun 14, 2024 (Actual)
- Completion
- Jun 14, 2024 (Actual)
- Last update posted
- Sep 15, 2025
2020 – 2024
United States locations
- U.S. sites
- 48
- U.S. states
- 24
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Velocity Clinical Research - Banning | Banning | California | 92220 | — |
| Paradigm Clinical Research | La Mesa | California | 91942 | — |
| Altus Research - Hunt - PPDS | Lake Worth | Florida | 33461 | — |
| Accel Research Sites - Nona Pediatric Center - ERN - PPDS | Orlando | Florida | 32829 | — |
| Tekton Research - Georgia - PPDS | Chamblee | Georgia | 30341 | — |
| IACT Health - Roswell - IACT - HyperCore - PPDS | Columbus | Georgia | 31904 | — |
| Meridian Clinical Research - (Macon Georgia) - Platinum - PPDS | Macon | Georgia | 31210 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research - Boise - PPDS | Meridian | Idaho | 83642 | — |
| Olivo Medical and Wellness Center | Chicago | Illinois | 60618 | — |
| Velocity Clinical Research - Valparaiso | Valparaiso | Indiana | 46383 | — |
| Meridian Clinical Research (Sioux City - Iowa) | Sioux City | Iowa | 51106 | — |
| Alliance for Multispecialty Research -El Dorado | El Dorado | Kansas | 67042 | — |
| Johnson County Clin-Trials | Lenexa | Kansas | 66219 | — |
| Velocity Clinical Research - Metairie - PPDS | Metairie | Louisiana | 70006 | — |
| University of Massachusetts Medical School, Molecu | Worcester | Massachusetts | 01655 | — |
| Clinical Research Institute, Inc - CRN - PPDS | Minneapolis | Minnesota | 55402 | — |
| Velocity Clinical Research - Gulfport - PPDS | Gulfport | Mississippi | 39503 | — |
| Sundance Clinical Research - Platinum - PPDS | St Louis | Missouri | 63141 | — |
| Meridian Clinical Research (Hastings-Nebraska) - Platinum - PPDS | Hastings | Nebraska | 68901 | — |
| Quality Clinical Research - HyperCore - PPDS | Omaha | Nebraska | 68114 | — |
| Meridian Clinical Research (Omaha-Nebraska) - Platinum - PPDS | Omaha | Nebraska | 68134 | — |
| Velocity Clinical Research - Albuquerque - PPDS | Albuquerque | New Mexico | 87102 | — |
| Child Healthcare Associates - East Syracuse | East Syracuse | New York | 13210 | — |
| Meridian Clinical Research (Endwell-New York) - Platinum - PPDS | Endwell | New York | 13901 | — |
| Velocity Clinical Research - Cincinnati - PPDS | Cincinnati | Ohio | 45242 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Vital Prospects Clinical Research Institute PC - CRN - PPDS | Tulsa | Oklahoma | 74136 | — |
| Cyn3rgy Research - ClinEdge - PPDS | Gresham | Oregon | 97030 | — |
| Velocity Clinical Research - Providence - PPDS | East Greenwich | Rhode Island | 02818 | — |
| Coastal Pediatric Associates | Charleston | South Carolina | 29414 | — |
| Meridian Clinical Research - Charleston, SC | Charleston | South Carolina | 29414 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Benchmark Research | Austin | Texas | 78705 | — |
| Coastal Bend Research Center | Corpus Christi | Texas | 78404 | — |
| ACRC Trials | Frisco | Texas | 75033 | — |
| DM Clinical Research - Kool Kids Pediatrics - ERN - PPDS | Houston | Texas | 77064 | — |
| Clinical Trials of Texas, Inc. - PPDS | San Antonio | Texas | 78229 | — |
| Tekton Research | San Antonio | Texas | 78229 | — |
| Tekton Research | San Antonio | Texas | 78244 | — |
| Cope Family Medicine - Ogden Clinic - CCT | Bountiful | Utah | 84010 | — |
| Wee Care Pediatrics - Kaysville | Kaysville | Utah | 84037 | — |
| Cottonwood Pediatrics | Murray | Utah | 84107 | — |
| South Ogden Family Medicine/Ogden Clinic - CCT Research | South Ogden | Utah | 84405 | — |
| Alliance for Multispecialty Research | Syracuse | Utah | 84075 | — |
| Advanced Clinical Research - Jordan Valley - ERN - PPDS | West Jordan | Utah | 84088 | — |
| Meridian Clinical Research (Norfolk, Virginia) | Norfolk | Virginia | 68701 | — |
| Meridian Clinical Research - Family Practice Ports - Portsmouth - Platinum - PPDS | Portsmouth | Virginia | 23703 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04649151, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04649151 live on ClinicalTrials.gov.