A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss
Public ClinicalTrials.gov record NCT04660643. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo for Maintenance of Weight Loss in Participants Without Type 2 Diabetes Who Have Obesity or Are Overweight With Weight-Related Comorbidities: A Randomized, Double-Blind, Placebo-Controlled Trial (SURMOUNT-4)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a study of tirzepatide in participants with obesity or overweight. The main purpose was to learn more about how tirzepatide maintained body weight loss. The study had two phases: a lead-in phase in which all participants took tirzepatide and a treatment phase in which participants either continued tirzepatide or switched to placebo. The study lasted about 2 years (25 visits).
Study identification
- NCT ID
- NCT04660643
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 783 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 28, 2021
- Primary completion
- Apr 24, 2023
- Completion
- May 17, 2023
- Last update posted
- May 21, 2024
2021 – 2023
United States locations
- U.S. sites
- 48
- U.S. states
- 27
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cahaba Research | Pelham | Alabama | 35124 | — |
| Scripps Memorial Hospital La Jolla | La Jolla | California | 92037 | — |
| National Research Institute - Wilshire | Los Angeles | California | 90057 | — |
| National Research Institute | Panorama City | California | 91402 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| New West Physicians Clinical Research | Golden | Colorado | 80401 | — |
| Optumcare Colorado Springs - Monument | Monument | Colorado | 80132 | — |
| Care Partners Clinical Research | Jacksonville | Florida | 32277 | — |
| South Florida Clinical Research Institute | Margate | Florida | 33063 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Endocrine Research Solutions, Inc. | Roswell | Georgia | 30076 | — |
| SKY Clinical Research Network Group-Blake | Union City | Georgia | 30291 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Rocky Mountain Clinical Research | Idaho Falls | Idaho | 83404 | — |
| Healthcare Research Network - Chicago | Flossmoor | Illinois | 60422 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| Midwest Institute For Clinical Research | Indianapolis | Indiana | 46260 | — |
| American Health Network of Indiana, LLC - New Albany | New Albany | Indiana | 47150 | — |
| Cotton O'Neil Clinic | Topeka | Kansas | 66606 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Centennial Medical Group | Elkridge | Maryland | 21075 | — |
| MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland | 20782 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Glacier View Research Institute - Endocrinology | Kalispell | Montana | 59901 | — |
| Weill Cornell Medical College | New York | New York | 10065 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest | Greensboro | North Carolina | 27408 | — |
| Wake Forest University Baptist Medical Center (WFUBMC) | Winston-Salem | North Carolina | 27157 | — |
| Lillestol Research | Fargo | North Dakota | 58104 | — |
| Aventiv Research Inc | Columbus | Ohio | 43213 | — |
| Intend Research, LLC | Norman | Oklahoma | 73069 | — |
| Summit Research Network | Portland | Oregon | 97210 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| The University of Texas Health Science Center at Houston | Bellaire | Texas | 77401 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77043 | — |
| North Hills Family Medicine/North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Health Research of Hampton Roads, Inc. | Newport News | Virginia | 23606 | — |
| Capital Clinical Research Center | Olympia | Washington | 98502 | — |
| Rainier Clinical Research Center | Renton | Washington | 98057 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 22 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04660643, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 21, 2024 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04660643 live on ClinicalTrials.gov.