A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
Public ClinicalTrials.gov record NCT04663308. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the Treatment of Cholestatic Pruritus in Patients With Primary Sclerosing Cholangitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Sclerosing Cholangitis (PSC), and to assess the possible impact on the disease progression of PSC.
Study identification
- NCT ID
- NCT04663308
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 182 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 18, 2020 (Actual)
- Primary completion
- Feb 20, 2026 (Actual)
- Completion
- Mar 2028 (Estimated)
- Last update posted
- Oct 19, 2026
2020 – 2028
United States locations
- U.S. sites
- 34
- U.S. states
- 17
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern California Research Center | Coronado | California | 92118 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California, Davis | Sacramento | California | 95817 | — |
| California Pacific Medical Center Research Institute | San Francisco | California | 94109 | — |
| University of Colorado - Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| University of Miami - Schiff Center for Liver Diseases | Miami | Florida | 33136 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Southern Therapy and Advanced Research LLC | Jackson | Mississippi | 39216 | — |
| Northwell Health | Manhasset | New York | 11030 | — |
| New York University Langone Health | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Columbia University Medical Center - Presbyterian Hospital and Vanderbilt Clinic | New York | New York | 10032 | — |
| University of Rochester Medical Center - Strong Memorial Hospital | Rochester | New York | 14642 | — |
| Duke Health - Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Science 37, Inc (Remote-homebased Telemedicine) | Morrisville | North Carolina | 27560 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Einstein Healthcare Network - Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Galen Medical Group | Hixson | Tennessee | 37343 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| The Liver Institute At Methodist Dallas Medical Center | Dallas | Texas | 75203 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Liver Associates of Texas | Houston | Texas | 77030 | — |
| University of Utah Health Care | Salt Lake City | Utah | 84132 | — |
| Bon Secours Liver Institution of Hampton Roads Mary Immaculate Hospital Office | Newport News | Virginia | 23603 | — |
| Richmond Community Hospital LLC | Richmond | Virginia | 23226 | — |
| University of Washington - Harborview Medical Center | Seattle | Washington | 98104 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 69 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04663308, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 19, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04663308 live on ClinicalTrials.gov.