Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

ClinicalTrials.gov ID: NCT04671667

Public ClinicalTrials.gov record NCT04671667. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 10, 2026, 8:53 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Randomized Trial of Adjuvant Therapy With Pembrolizumab After Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma With High Risk Features

Study identification

NCT ID: NCT04671667
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 188 participants

Conditions and interventions

Conditions

Interventions

Carboplatin Drug
Cisplatin Drug
Computed Tomography Procedure
Intensity-Modulated Radiation Therapy Radiation
Magnetic Resonance Imaging Procedure
Pembrolizumab Biological
Proton Beam Radiation Therapy Radiation

Drug · Procedure · Radiation + 1 more

Eligibility (public fields only)

Age range: 18 Years to 79 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 26, 2021
Primary completion: Jun 29, 2029
Completion: Jun 29, 2029
Last update posted: May 7, 2026

2021 – 2029

United States locations

U.S. sites: 177
U.S. states: 35
U.S. cities: 130

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Active, not recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
Kaiser Permanente-Anaheim	Anaheim	California	92806	Recruiting
Kaiser Permanente-Bellflower	Bellflower	California	90706	Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care	Irvine	California	92612	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Active, not recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Kaiser Permanente-Ontario	Ontario	California	91761	Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	95661	Active, not recruiting
Sutter Roseville Medical Center	Roseville	California	95661	Active, not recruiting
California Protons Cancer Therapy Center	San Diego	California	92121	Active, not recruiting
Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	06510	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	06385	Recruiting
MedStar Washington Hospital Center	Washington D.C.	District of Columbia	20010	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Moffitt Cancer Center-International Plaza	Tampa	Florida	33607	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center at Wesley Chapel	Wesley Chapel	Florida	33544	Recruiting
Emory Proton Therapy Center	Atlanta	Georgia	30308	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Suspended
Memorial Health University Medical Center	Savannah	Georgia	31404	Suspended
Northwestern University	Chicago	Illinois	60611	Recruiting
John H Stroger Jr Hospital of Cook County	Chicago	Illinois	60612	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Suspended
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Active, not recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
HSHS Saint Elizabeth's Hospital	O'Fallon	Illinois	62269	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
The Carle Foundation Hospital	Urbana	Illinois	61801	Suspended
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Reid Health	Richmond	Indiana	47374	Active, not recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Heartland Oncology and Hematology LLP	Council Bluffs	Iowa	51503	Recruiting
Methodist Jennie Edmundson Hospital	Council Bluffs	Iowa	51503	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
Iowa Lutheran Hospital	Des Moines	Iowa	50316	Suspended
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
Methodist West Hospital	West Des Moines	Iowa	50266-7700	Suspended
University of Kansas Cancer Center	Kansas City	Kansas	66160	Active, not recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Active, not recruiting
University of Kansas Hospital-Indian Creek Campus	Overland Park	Kansas	66211	Active, not recruiting
University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	66205	Active, not recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
Maryland Proton Treatment Center	Baltimore	Maryland	21201	Suspended
University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	21201	Recruiting
Central Maryland Radiation Oncology in Howard County	Columbia	Maryland	21044	Recruiting
UM Baltimore Washington Medical Center/Tate Cancer Center	Glen Burnie	Maryland	21061	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Suspended
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Active, not recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Active, not recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Suspended
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Suspended
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Active, not recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Active, not recruiting
University of Kansas Cancer Center - North	Kansas City	Missouri	64154	Active, not recruiting
University of Kansas Cancer Center - Lee's Summit	Lee's Summit	Missouri	64064	Active, not recruiting
University of Kansas Cancer Center at North Kansas City Hospital	North Kansas City	Missouri	64116	Active, not recruiting
Mercy Hospital Springfield	Springfield	Missouri	65804	Suspended
Washington University School of Medicine	St Louis	Missouri	63110	Active, not recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Active, not recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Active, not recruiting
Mercy Hospital Saint Louis	St Louis	Missouri	63141	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC	Omaha	Nebraska	68114	Recruiting
Nebraska Methodist Hospital	Omaha	Nebraska	68114	Recruiting
Oncology Associates PC	Omaha	Nebraska	68114	Suspended
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Active, not recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Mount Sinai Union Square	New York	New York	10003	Recruiting
Mount Sinai Chelsea	New York	New York	10011	Recruiting
Mount Sinai Hospital	New York	New York	10029	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Recruiting
Montefiore Medical Center-Einstein Campus	The Bronx	New York	10461	Recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Wilmot Cancer Institute at Webster	Webster	New York	14580	Recruiting
Randolph Hospital	Asheboro	North Carolina	27203	Suspended
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Cone Health Cancer Center	Greensboro	North Carolina	27403	Recruiting
Annie Penn Memorial Hospital	Reidsville	North Carolina	27320	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
Indu and Raj Soin Medical Center	Beavercreek	Ohio	45431	Active, not recruiting
Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	45459	Active, not recruiting
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
Premier Blood and Cancer Center	Dayton	Ohio	45409	Recruiting
Dayton Physician LLC - Englewood	Dayton	Ohio	45415	Active, not recruiting
Miami Valley Hospital North	Dayton	Ohio	45415	Recruiting
Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	45005-1066	Recruiting
Dayton Physicians LLC-Atrium	Franklin	Ohio	45005	Active, not recruiting
Miami Valley Cancer Care and Infusion	Greenville	Ohio	45331	Recruiting
Greater Dayton Cancer Center	Kettering	Ohio	45409	Active, not recruiting
Kettering Medical Center	Kettering	Ohio	45429	Active, not recruiting
Upper Valley Medical Center	Troy	Ohio	45373	Recruiting
Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	73505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Clackamas Radiation Oncology Center	Clackamas	Oregon	97015	Suspended
Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	97015	Suspended
Providence Newberg Medical Center	Newberg	Oregon	97132	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
UPMC Altoona	Altoona	Pennsylvania	16601	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
UPMC Cancer Center at UPMC Horizon	Farrell	Pennsylvania	16121	Recruiting
Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	17837	Recruiting
UPMC Hillman Cancer Center - New Castle	New Castle	Pennsylvania	16105	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	19114	Recruiting
Temple University Hospital	Philadelphia	Pennsylvania	19140	Active, not recruiting
UPMC-Saint Margaret	Pittsburgh	Pennsylvania	15215	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	15232	Active, not recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
UPMC Memorial	York	Pennsylvania	17408	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
Avera Cancer Institute at Yankton	Yankton	South Dakota	57078	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Active, not recruiting
VCU Massey Cancer Center at Stony Point	Richmond	Virginia	23235	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Langlade Hospital and Cancer Center	Antigo	Wisconsin	54409	Recruiting
ThedaCare Regional Cancer Center	Appleton	Wisconsin	54911	Recruiting
HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	54701	Active, not recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	53051	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Drexel Town Square Health Center	Oak Creek	Wisconsin	53154	Recruiting
Aspirus Cancer Care - James Beck Cancer Center	Rhinelander	Wisconsin	54501	Recruiting
Aspirus Cancer Care - Stevens Point	Stevens Point	Wisconsin	54481	Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	54235-1495	Recruiting
Aspirus Regional Cancer Center	Wausau	Wisconsin	54401	Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	53095	Recruiting
Aspirus Cancer Care - Wisconsin Rapids	Wisconsin Rapids	Wisconsin	54494	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04671667, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04671667 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →