ClinicalTrials.gov record
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
ClinicalTrials.gov ID: NCT04685135
Public ClinicalTrials.gov record NCT04685135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Study identification
- NCT ID
- NCT04685135
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Mirati Therapeutics Inc.
- Industry
- Enrollment
- 453 participants
Conditions and interventions
Interventions
- Docetaxel Drug
- MRTX849 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 22, 2021
- Primary completion
- Dec 29, 2023
- Completion
- Jul 1, 2026
- Last update posted
- Jan 21, 2025
2021 – 2026
United States locations
- U.S. sites
- 112
- U.S. states
- 24
- U.S. cities
- 85
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 012-898 | Cerritos | California | 90703 | — |
| City of Hope - Duarte (Main Campus) | Duarte | California | 91010 | — |
| Local Institution - 012-898 D | Glendale | California | 91204 | — |
| Local Institution - 012-910-A | Huntington Beach | California | 92648 | — |
| Local Institution - 012-910-C | Irvine | California | 92618 | — |
| City Of Hope | Long Beach | California | 90808 | — |
| Local Institution - 012-910-F | Long Beach | California | 90813 | — |
| Local Institution - 012-910-D | Newport Beach | California | 92663 | — |
| Local Institution - 012-898 C | Santa Ana | California | 92705 | — |
| Providence Medical Group - Santa Rosa | Santa Rosa | California | 95403 | — |
| Local Institution - 012-910-E | Torrance | California | 90505 | — |
| Local Institution - 012-951-B | Denver | Colorado | 80218 | — |
| SCL Health - Saint Joseph Hospital Cancer Center | Lafayette | Colorado | 80026 | — |
| Local Institution - 012-872 | Lone Tree | Colorado | 80124 | — |
| Local Institution - 012-951-A | Wheat Ridge | Colorado | 80033-6005 | — |
| Local Institution - 012-562-B | Fleming Island | Florida | 32003 | — |
| Holy Cross Health Fort Lauderdale - Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| 21st Century Oncology of Jacksonville - North Lee Street | Jacksonville | Florida | 32204 | — |
| Local Institution - 012-562-D | Jacksonville | Florida | 32204 | — |
| Local Institution - 012-562-E | Jacksonville | Florida | 32207 | — |
| Local Institution - 012-562-A | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-C | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-F | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-G | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562 | Jacksonville | Florida | 32256 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Orlando Health University of Florida Health Cancer Center - Head and Neck Center | Orlando | Florida | 32806 | — |
| USOR - Woodlands Medical Specialists | Pensacola | Florida | 32503 | — |
| Local Institution - 012-839 | Plantation | Florida | 33322 | — |
| University Cancer & Blood Center (UCBC) - Athens | Athens | Georgia | 30607 | — |
| Local Institution - 012-835 - A | Austell | Georgia | 30106 | — |
| Local Institution - 012-835 - B | Carrollton | Georgia | 30117 | — |
| Local Institution - 012-835 - C | Cartersville | Georgia | 30121 | — |
| Local Institution - 012-835 - D | Douglasville | Georgia | 30134 | — |
| Northwest Georgia Oncology Centers Wellstar - Marietta | Marietta | Georgia | 30060 | — |
| University of Illinois Hospital & Health Sciences System | Chicago | Illinois | 60612 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Local Institution - 012-972 C | Harvey | Illinois | 60426 | — |
| Local Institution - 012-972 A | New Lenox | Illinois | 60451 | — |
| Illinois Cancer Specialists - Niles | Niles | Illinois | 60714 | — |
| Local Institution - 012-972 B | Orland Park | Illinois | 60462 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Local Institution - 012-569 | Indianapolis | Indiana | 46237 | — |
| Local Institution - 012-569 - B | Lafayette | Indiana | 47905 | — |
| Local Institution - 012-569 - C | Lafayette | Indiana | 47905 | — |
| Local Institution - 012-569 - A | Mooresville | Indiana | 46158 | — |
| Franciscan Health Munster | Munster | Indiana | 46321 | — |
| Local Institution - 012-942-B | Chanute | Kansas | 66720 | — |
| Local Institution - 012-942-C | Dodge City | Kansas | 67801 | — |
| Local Institution - 012-942-D | El Dorado | Kansas | 67042 | — |
| Local Institution - 012-942-E | Independence | Kansas | 67301 | — |
| Local Institution - 012-942-F | Kingman | Kansas | 67068 | — |
| Local Institution - 012-942-G | Liberal | Kansas | 67901 | — |
| Local Institution - 012-942-H | McPherson | Kansas | 67460 | — |
| Local Institution - 012-942-I | Newton | Kansas | 67114 | — |
| Local Institution - 012-942-J | Parsons | Kansas | 67357 | — |
| Local Institution - 012-942-K | Pratt | Kansas | 67124 | — |
| Local Institution - 012-942-L | Salina | Kansas | 67401 | — |
| Local Institution - 012-942-M | Wellington | Kansas | 67152 | — |
| Local Institution - 012-820 | Westwood | Kansas | 66205 | — |
| Local Institution - 012-942-A | Wichita | Kansas | 67208 | — |
| Local Institution - 012-942 | Wichita | Kansas | 67214 | — |
| Local Institution - 012-942-N | Winfield | Kansas | 67156 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Local Institution - 012-911 A | New Orleans | Louisiana | 70112 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Local Institution - 012-954 - A | Kennebunk | Maine | 04043 | — |
| New England Cancer Specialists - Scarborough | Scarborough | Maine | 04074 | — |
| Local Institution - 012-954 - B | Topsham | Maine | 04086 | — |
| Frederick Health | Frederick | Maryland | 21702 | — |
| Local Institution - 012-974-B | Novi | Michigan | 48374 | — |
| Local Institution - 012-974-C | Novi | Michigan | 48374 | — |
| Ascension Providence Cancer Center - Southfield | Southfield | Michigan | 48075 | — |
| Local Institution - 012-974-A | Southfield | Michigan | 48075 | — |
| Central Care Cancer Center - Bolivar | Bolivar | Missouri | 65613 | — |
| Local Institution - 012-841 - A | Billings | Montana | 59101 | — |
| St. Vincent Healthcare Cancer Centers of Montana | Billings | Montana | 59101 | — |
| Sisters of Charity of Leavenworth Health St. Marys | Billings | Montana | 59102 | — |
| Astera Cancer Care - East Brunswick | East Brunswick | New Jersey | 08816 | — |
| Local Institution - 012-975 - A | Edison | New Jersey | 08820 | — |
| Local Institution - 012-975 - B | Monroe | New Jersey | 08831 | — |
| Local Institution - 012-975 - C | Somerset | New Jersey | 08873 | — |
| Local Institution - 012-975 - D | Somerville | New Jersey | 08876 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210-2306 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Kettering Health Cancer Center - Main Campus | Kettering | Ohio | 45429 | — |
| Oregon Oncology Specialists | Salem | Oregon | 97301 | — |
| Lifespan Cancer Institute - Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Local Institution - 012-960-A | Providence | Rhode Island | 02906 | — |
| Prisma Health Cancer Institute - Faris Road | Greenville | South Carolina | 29605 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Texas Oncology - Dallas Fort Worth (DFW) - Arlington Cancer Center North | Arlington | Texas | 76012 | — |
| Texas Oncology - Dallas Fort Worth (DFW) - South Austin | Austin | Texas | 78745 | — |
| US Oncology Research (USOR) | Irving | Texas | 75063 | — |
| Texas Oncology - Sherman | Sherman | Texas | 75090 | — |
| Utah Cancer Specialists - UCS Cancer Center | Salt Lake City | Utah | 84106 | — |
| Local Institution - 012-976-A | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-B | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-C | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-D | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-E | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-F | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-G | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-H | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-I | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-814 - B | Arlington | Virginia | 22205 | — |
| UVA Health - University Hospital | Charlottesville | Virginia | 22908-0674 | — |
| Local Institution - 012-814 - A | Fairfax | Virginia | 22031 | — |
| NEXT Virginia | Fairfax | Virginia | 22031 | — |
| Local Institution - 012-814 - C | Gainesville | Virginia | 20155 | — |
| Local Institution - 012-814 - D | Leesburg | Virginia | 20176 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 231 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04685135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2025 · Synced May 12, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04685135 live on ClinicalTrials.gov.