ClinicalTrials.gov record
Phase 3 Study of MRTX849 (Adagrasib) vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
ClinicalTrials.gov ID: NCT04685135
Public ClinicalTrials.gov record NCT04685135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 3 Study of MRTX849 Versus Docetaxel in Patients With Previously Treated Non-Small Cell Lung Cancer With KRAS G12C Mutation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase 3 study will evaluate the efficacy of the investigational agent MRTX849 (adagrasib) versus docetaxel in patients who have been previously treated for metastatic NSCLC with a KRAS G12C mutation.
Study identification
- NCT ID
- NCT04685135
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 453 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 22, 2021
- Primary completion
- Dec 29, 2023
- Completion
- Oct 29, 2026
- Last update posted
- Aug 10, 2026
2021 – 2026
United States locations
- U.S. sites
- 112
- U.S. states
- 24
- U.S. cities
- 85
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 012-898 | Cerritos | California | 90703 | — |
| Local Institution - 012-910 | Duarte | California | 91010 | — |
| Local Institution - 012-898 D | Glendale | California | 91204 | — |
| Local Institution - 012-910-A | Huntington Beach | California | 92648 | — |
| Local Institution - 012-910-C | Irvine | California | 92618 | — |
| Local Institution - 012-910-B | Long Beach | California | 90808 | — |
| Local Institution - 012-910-F | Long Beach | California | 90813 | — |
| Local Institution - 012-910-D | Newport Beach | California | 92663 | — |
| Local Institution - 012-898 C | Santa Ana | California | 92705 | — |
| Local Institution - 012-858 | Santa Rosa | California | 95403 | — |
| Local Institution - 012-910-E | Torrance | California | 90505 | — |
| Local Institution - 012-951-B | Denver | Colorado | 80218 | — |
| Local Institution - 012-951 | Lafayette | Colorado | 80026 | — |
| Local Institution - 012-872 | Lone Tree | Colorado | 80124 | — |
| Local Institution - 012-951-A | Wheat Ridge | Colorado | 80033-6005 | — |
| Local Institution - 012-562-B | Fleming Island | Florida | 32003 | — |
| Local Institution - 012-968 | Fort Lauderdale | Florida | 33308 | — |
| Local Institution - 012-562-D | Jacksonville | Florida | 32204 | — |
| Local Institution - 012-853 | Jacksonville | Florida | 32204 | — |
| Local Institution - 012-562-E | Jacksonville | Florida | 32207 | — |
| Local Institution - 012-562-A | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-C | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-F | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562-G | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-562 | Jacksonville | Florida | 32256 | — |
| Local Institution - 012-825 | Miami Beach | Florida | 33140 | — |
| Local Institution - 012-973 | Orlando | Florida | 32806 | — |
| Local Institution - 012-877 | Pensacola | Florida | 32503 | — |
| Local Institution - 012-839 | Plantation | Florida | 33322 | — |
| Local Institution - 012-941 | Athens | Georgia | 30607 | — |
| Local Institution - 012-835 - A | Austell | Georgia | 30106 | — |
| Local Institution - 012-835 - B | Carrollton | Georgia | 30117 | — |
| Local Institution - 012-835 - C | Cartersville | Georgia | 30121 | — |
| Local Institution - 012-835 - D | Douglasville | Georgia | 30134 | — |
| Local Institution - 012-835 | Marietta | Georgia | 30060 | — |
| Local Institution - 012-917 | Chicago | Illinois | 60612 | — |
| Local Institution - 012-972 | Chicago | Illinois | 60637 | — |
| Local Institution - 012-972 C | Harvey | Illinois | 60426 | — |
| Local Institution - 012-972 A | New Lenox | Illinois | 60451 | — |
| Local Institution - 012-883 | Niles | Illinois | 60714 | — |
| Local Institution - 012-972 B | Orland Park | Illinois | 60462 | — |
| Local Institution - 012-943 | Goshen | Indiana | 46526 | — |
| Local Institution - 012-569 | Indianapolis | Indiana | 46237 | — |
| Local Institution - 012-569 - B | Lafayette | Indiana | 47905 | — |
| Local Institution - 012-569 - C | Lafayette | Indiana | 47905 | — |
| Local Institution - 012-569 - A | Mooresville | Indiana | 46158 | — |
| Local Institution - 012-782 | Munster | Indiana | 46321 | — |
| Local Institution - 012-942-B | Chanute | Kansas | 66720 | — |
| Local Institution - 012-942-C | Dodge City | Kansas | 67801 | — |
| Local Institution - 012-942-D | El Dorado | Kansas | 67042 | — |
| Local Institution - 012-942-E | Independence | Kansas | 67301 | — |
| Local Institution - 012-942-F | Kingman | Kansas | 67068 | — |
| Local Institution - 012-942-G | Liberal | Kansas | 67901 | — |
| Local Institution - 012-942-H | McPherson | Kansas | 67460 | — |
| Local Institution - 012-942-I | Newton | Kansas | 67114 | — |
| Local Institution - 012-942-J | Parsons | Kansas | 67357 | — |
| Local Institution - 012-942-K | Pratt | Kansas | 67124 | — |
| Local Institution - 012-942-L | Salina | Kansas | 67401 | — |
| Local Institution - 012-942-M | Wellington | Kansas | 67152 | — |
| Local Institution - 012-820 | Westwood | Kansas | 66205 | — |
| Local Institution - 012-942-A | Wichita | Kansas | 67208 | — |
| Local Institution - 012-942 | Wichita | Kansas | 67214 | — |
| Local Institution - 012-942-N | Winfield | Kansas | 67156 | — |
| Local Institution - 012-965 | Lexington | Kentucky | 40503 | — |
| Local Institution - 012-911 A | New Orleans | Louisiana | 70112 | — |
| Local Institution - 012-911 | New Orleans | Louisiana | 70112 | — |
| Local Institution - 012-954 - A | Kennebunk | Maine | 04043 | — |
| Local Institution - 012-954 | Scarborough | Maine | 04074 | — |
| Local Institution - 012-954 - B | Topsham | Maine | 04086 | — |
| Local Institution - 012-856 | Frederick | Maryland | 21702 | — |
| Local Institution - 012-974-B | Novi | Michigan | 48374 | — |
| Local Institution - 012-974-C | Novi | Michigan | 48374 | — |
| Local Institution - 012-974-A | Southfield | Michigan | 48075 | — |
| Local Institution - 012-974 | Southfield | Michigan | 48075 | — |
| Local Institution - 012-952 | Bolivar | Missouri | 65613 | — |
| Local Institution - 012-841 - A | Billings | Montana | 59101 | — |
| Local Institution - 012-841 | Billings | Montana | 59101 | — |
| Local Institution - 012-846 | Billings | Montana | 59102 | — |
| Local Institution - 012-975 | East Brunswick | New Jersey | 08816 | — |
| Local Institution - 012-975 - A | Edison | New Jersey | 08820 | — |
| Local Institution - 012-975 - B | Monroe | New Jersey | 08831 | — |
| Local Institution - 012-975 - C | Somerset | New Jersey | 08873 | — |
| Local Institution - 012-975 - D | Somerville | New Jersey | 08876 | — |
| Local Institution - 012-577 | Teaneck | New Jersey | 07666 | — |
| Local Institution - 012-962 | Syracuse | New York | 13210-2306 | — |
| Local Institution - 012-849 | Cleveland | Ohio | 44106 | — |
| Local Institution - 012-836 | Kettering | Ohio | 45429 | — |
| Local Institution - 012-967 | Salem | Oregon | 97301 | — |
| Local Institution - 012-960 | Providence | Rhode Island | 02903 | — |
| Local Institution - 012-960-A | Providence | Rhode Island | 02906 | — |
| Local Institution - 012-891 | Greenville | South Carolina | 29605 | — |
| Local Institution - 012-940 | Sioux Falls | South Dakota | 57105 | — |
| Local Institution - 012-888 | Arlington | Texas | 76012 | — |
| Local Institution - 012-892 | Austin | Texas | 78745 | — |
| Local Institution - 012-999 | Irving | Texas | 75063 | — |
| Local Institution - 012-890 | Sherman | Texas | 75090 | — |
| Local Institution - 012-976 | Salt Lake City | Utah | 84106 | — |
| Local Institution - 012-976-A | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-B | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-C | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-D | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-E | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-F | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-G | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-H | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-976-I | Salt Lake City | Utah | 84124 | — |
| Local Institution - 012-814 - B | Arlington | Virginia | 22205 | — |
| Local Institution - 012-953 | Charlottesville | Virginia | 22908-0674 | — |
| Local Institution - 012-814 - A | Fairfax | Virginia | 22031 | — |
| Local Institution - 012-814 | Fairfax | Virginia | 22031 | — |
| Local Institution - 012-814 - C | Gainesville | Virginia | 20155 | — |
| Local Institution - 012-814 - D | Leesburg | Virginia | 20176 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 268 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04685135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2026 · Synced Sep 3, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04685135 live on ClinicalTrials.gov.