RA-PRO PRAGMATIC TRIAL
Public ClinicalTrials.gov record NCT04692493. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Real-World Comparative Effectiveness Trial of Treatment Strategies in Patients With Rheumatoid Arthritis: The RA-PRO Pragmatic Trial (RA-PROPR)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The 2021 ACR RA treatment guideline, based on widely acknowledged low to moderate quality evidence, recommends switching to a non-tumor necrosis factor (TNFi) biologic (choose among existing medications, currently, rituximab, abatacept, tocilizumab, or sarilumab) or a targeted synthetic DMARD arm (tsDMARD; choose among existing medications, currently, tofacitinib, baricitinib, upadacitinib) in patients with active RA despite the use of a TNFi-biologic. In practice, most patients receive another TNFi-biologic, i.e., a second TNFi-biologic first. This is not based on solid evidence, but on arbitrary algorithms often proposed by health insurance plans, and/or physician experience and habit (TNFis launched 22 yrs ago vs. the first tsDMARD 8 years ago vs. first non-TNF-biologic launched 17 years ago). This study will fill a critical knowledge gap by generating CER data for important PROs between these treatment options, switching to a non-TNFi biologic or a tsDMARD in patients with active RA despite the use of a TNFi-biologic.
Study identification
- NCT ID
- NCT04692493
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 924 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2021
- Primary completion
- May 30, 2029
- Completion
- Jul 30, 2029
- Last update posted
- Jul 16, 2026
2021 – 2029
United States locations
- U.S. sites
- 48
- U.S. states
- 18
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| East Alabama Arthritis Center PC | Auburn | Alabama | 36830 | Recruiting |
| Bendcare, LLC | Birmingham | Alabama | 35244 | Recruiting |
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Recruiting |
| SunValley Arthritis Center, Ltd | Peoria | Arizona | 85381 | Recruiting |
| University of Arizona | Tucson | Arizona | 85724 | Recruiting |
| Pacific Arthritis Care Center | Los Angeles | California | 90045 | Recruiting |
| University of California, Los Angeles | Los Angeles | California | 90095 | Recruiting |
| Arthritis Medical Center | Nipomo | California | 93444 | Recruiting |
| Turlock Arthritis & Osteoporosis Center, | Turlock | California | 95382 | Recruiting |
| Center for Rheumatology Research | Woodland Hills | California | 91364 | Recruiting |
| George Munoz MD, PC | Aventura | Florida | 33180 | Recruiting |
| American Arthritis and Rheumatology Associates LLC | Clearwater | Florida | 33765 | Recruiting |
| CZ Rheumatology | Coral Springs | Florida | 33065 | Recruiting |
| American Arthritis and Rheumatology Associates LLC | Fort Lauderdale | Florida | 33309 | Recruiting |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| Palm Beach Rheumatology and Wellness | Jupiter | Florida | 33458 | Recruiting |
| Arthritis & Rheumatology Center of South Florida | Margate | Florida | 33063 | Recruiting |
| Life Medical Research Group | Miami Gardens | Florida | 33014 | Recruiting |
| Southwest Florida Rheumatology | Riverview | Florida | 33569 | Recruiting |
| Southeast Georgia Physician Associates-Rheumatology | Brunswick | Georgia | 31520 | Recruiting |
| Indiana University Health | Carmel | Indiana | 46280 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21224 | Recruiting |
| Tufts University | Boston | Massachusetts | 02111 | Recruiting |
| University of Massachusetts Chan Medical School | Worcester | Massachusetts | 01655 | Recruiting |
| American Arthritis and Rheumatology Associates -Mi PLLC | Okemos | Michigan | 48864 | Recruiting |
| Saint Paul Rheumatology, P.A. | Eagan | Minnesota | 55121 | Recruiting |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Dr. Jayashree Sinha | Clovis | New Mexico | 88101 | Recruiting |
| Inspire Santa Fe Medical Group | Santa Fe | New Mexico | 87505 | Recruiting |
| New York University | New York | New York | 10016 | Recruiting |
| Hospital for Special Surgery | New York | New York | 10021 | Recruiting |
| University Hospital Cleveland Medical Ctr | Cleveland | Ohio | 44106 | Recruiting |
| The MetroHealth System | Cleveland | Ohio | 44109 | Recruiting |
| Arthritis and Rheumatology of Southwest Ohio | Liberty Township | Ohio | 45069 | Recruiting |
| Southern Ohio Rheumatology | Wheelersburg | Ohio | 45694 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | Recruiting |
| Rheumatology and Arthritis Care Center | Exton | Pennsylvania | 19341-2547 | Recruiting |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| PA Regional Center for Arthritis and Osteoporosis Research | Wyomissing | Pennsylvania | 19610 | Recruiting |
| Cumberland Rhematology | Crossville | Tennessee | 38555 | Recruiting |
| Vanderbilt University | Nashville | Tennessee | 37235 | Recruiting |
| Heritage Rheumatology and Arthritis Care | Colleyville | Texas | 76034 | Recruiting |
| Southwest Medical Center | Dallas | Texas | 75235 | Recruiting |
| Texas Arthritis Center, PA | El Paso | Texas | 77902 | Recruiting |
| American Arthritis and Rheumatology Associates-Tx PLLC | Harlingen | Texas | 78550 | Recruiting |
| Baylor University | Houston | Texas | 77030 | Recruiting |
| Northern Virginia Center for Arthritis-Reston | Reston | Virginia | 20190 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04692493, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 16, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04692493 live on ClinicalTrials.gov.