NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial
Public ClinicalTrials.gov record NCT04698681. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes in Patients With Stage IV, 1L Non-Small Cell Lung Cancer to Determine Eligibility for the KEAPSAKE Clinical Trial (NCT04265534)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter screening protocol designed to identify patients with NSCLC who have tumor mutations in the KEAP1 or NRF2/NFE2L2 genes in order to determine potential eligibility for a biomarker selected clinical trial (CX-839-014, otherwise known as the KEAPSAKE trial). Circulating tumor DNA (ctDNA) present in blood samples collected from eligible patients will be analyzed by next generation sequencing (NGS) for selected biomarkers. A commercial liquid biopsy NGS test will be provided to study participants free of charge.
Study identification
- NCT ID
- NCT04698681
- Recruitment status
- Terminated
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 20 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 19, 2021 (Actual)
- Primary completion
- Nov 5, 2021 (Actual)
- Completion
- Feb 9, 2022 (Actual)
- Last update posted
- Mar 13, 2023
2021 – 2022
United States locations
- U.S. sites
- 63
- U.S. states
- 12
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center | Daphne | Alabama | 36526 | — |
| Southern Cancer Center - 3 Mobile Infirmary Circle | Mobile | Alabama | 36607 | — |
| Southern Cancer Center - Dauphin St | Mobile | Alabama | 36608 | — |
| Southern Cancer Center - Providence Hospital | Mobile | Alabama | 36608 | — |
| Arizona Oncology Associates - Glendale | Glendale | Arizona | 85308 | — |
| Arizona Oncology Associates - E. Highland Ave. | Phoenix | Arizona | 85016 | — |
| Arizona Oncology Associates - N. 27th Ave. | Phoenix | Arizona | 85027 | — |
| Arizona Oncology Associates | Scottsdale | Arizona | 85258 | — |
| Arizona Oncology Associates - Tempe | Tempe | Arizona | 85284 | — |
| Rocky Mountain Cancer Centers - Aurora | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers - Boulder | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado | 80112 | — |
| Rocky Mountain Cancer Centers - Colorado Springs | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers - Williams Street | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers - E. Hale Parkway | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers - Englewood | Englewood | Colorado | 80113 | — |
| Rocky Mountain Cancer Centers - Lakewood | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers - Littleton | Littleton | Colorado | 80120-4413 | — |
| Rocky Mountain Cancer Centers - Lone Tree | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers - Longmont | Longmont | Colorado | 80501 | — |
| Rocky Mountain Cancer Centers - Pueblo | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers - Thornton | Thornton | Colorado | 80260 | — |
| Medical Oncology Hematology Consultants | Newark | Delaware | 19713 | — |
| Woodlands Medical Specialists | Pensacola | Florida | 32503 | — |
| Maryland Oncology Hematology - Bethesda | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology - Brandywine | Brandywine | Maryland | 20613 | — |
| Maryland Oncology Hematology - Clinton | Clinton | Maryland | 20735 | — |
| Maryland Oncology Hematology | Columbia | Maryland | 21044 | — |
| Maryland Hematology Oncology - Frederick | Frederick | Maryland | 21702 | — |
| Maryland Oncology Hematology - Lanham | Lanham | Maryland | 20706 | — |
| Maryland Hematology Oncology - Rockville | Rockville | Maryland | 20850 | — |
| Maryland Hematology Oncology - Silver Spring | Silver Spring | Maryland | 20904 | — |
| Oncology Hematology Care - Mercy Health Blvd | Cincinnati | Ohio | 45211 | — |
| Oncology Hematology Care - Malsbary Rd | Cincinnati | Ohio | 45242 | — |
| Oncology Hematology Care - Ivy Gateway | Cincinnati | Ohio | 45245 | — |
| Oncology Hematology Care - Fairfield | Fairfield | Ohio | 45014 | — |
| Northwest Cancer Specialists - NE Hoyt St | Portland | Oregon | 97213-2982 | — |
| Northwest Cancer Specialists - N. Broadway | Portland | Oregon | 97227 | — |
| Northwest Cancer Specialists | Tigard | Oregon | 97223 | — |
| Consultants in Medical Oncology and Hematology | Broomall | Pennsylvania | 19008 | — |
| Consultants in Medical Oncology and Hematology | Horsham | Pennsylvania | 19044 | — |
| Consultants in Medical Oncology and Hematology | Wynnewood | Pennsylvania | 19096 | — |
| Texas Oncology - West Texas Amarillo | Amarillo | Texas | 79106 | — |
| Texas Oncology - Beaumont | Beaumont | Texas | 77701 | — |
| Texas Oncology - Beaumont Mamie McFaddin Ward Cancer Center | Beaumont | Texas | 77702-1449 | — |
| Texas Oncology - Carrollton | Carrollton | Texas | 75010 | — |
| Texas Oncology - Denton | Denton | Texas | 76201 | — |
| Texas Oncology - Flower Mound | Flower Mound | Texas | 75028 | — |
| Texas Oncology Cancer Care and Research | Harlingen | Texas | 78550 | — |
| Texas Oncology - Longview Cancer Center | Longview | Texas | 75601 | — |
| Texas Oncology - McAllen | McAllen | Texas | 78503 | — |
| Texas Oncology - West Texas Midland | Midland | Texas | 79701 | — |
| Texas Oncology - West Texas Odessa | Odessa | Texas | 79761 | — |
| Texas Oncology - Sherman | Sherman | Texas | 75090 | — |
| Texas Oncology - Tyler | Tyler | Texas | 75702 | — |
| Texas Oncology - Weslaco | Weslaco | Texas | 78596 | — |
| Texas Oncology - West Texas Wichita Falls | Wichita Falls | Texas | 76310 | — |
| Virginia Oncology Associaties | Chesapeake | Virginia | 23320 | — |
| Virginia Oncology Associates | Hampton | Virginia | 23666 | — |
| Virginia Oncology Associates | Newport News | Virginia | 23606 | — |
| Virginia Cancer Specialists | Norfolk | Virginia | 23502 | — |
| Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Northwest Cancer Specialists | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04698681, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 13, 2023 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04698681 live on ClinicalTrials.gov.