Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)
Public ClinicalTrials.gov record NCT04706975. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Proof-of-concept Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Adult Subjects With Notalgia Paresthetica
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of twice-daily (BID) oral difelikefalin (CR845) in adult subjects with notalgia paresthetica and moderate to severe pruritus.
Study identification
- NCT ID
- NCT04706975
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 126 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 11, 2021 (Actual)
- Primary completion
- May 18, 2022 (Actual)
- Completion
- Jun 30, 2022 (Actual)
- Last update posted
- May 22, 2023
2021 – 2022
United States locations
- U.S. sites
- 26
- U.S. states
- 15
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cara Therapeutics Study Site | Fort Smith | Arkansas | 72916 | — |
| Cara Therapeutics Study Site | Hot Springs | Arkansas | 71913 | — |
| Cara Therapeutics Study Site | Rogers | Arkansas | 72758 | — |
| Cara Therapeutics Study Site | Fountain Valley | California | 92708 | — |
| Cara Therapeutics Study Site | Los Angeles | California | 90033 | — |
| Cara Therapeutics Study Site | San Diego | California | 92122 | — |
| Cara Therapeutics Study Site | Santa Monica | California | 90404 | — |
| Cara Therapeutics Study Site | Cromwell | Connecticut | 06416 | — |
| Cara Therapeutics Study Site | Coral Gables | Florida | 33134 | — |
| Cara Therapeutics Study Site | Margate | Florida | 33063 | — |
| Cara Therapeutics Study Site | Miami | Florida | 33144 | — |
| Cara Therapeutics Study Site | North Miami Beach | Florida | 33162 | — |
| Cara Therapeutics Study Site | Sandy Springs | Georgia | 30328 | — |
| Cara Therapeutics Study Site | Indianapolis | Indiana | 46250 | — |
| Cara Therapeutics Study Site | Plainfield | Indiana | 46168 | — |
| Cara Therapeutics Study Site | Metairie | Louisiana | 70006 | — |
| Cara Therapeutics Study Site | New York | New York | 10029 | — |
| Cara Therapeutics Study Site | High Point | North Carolina | 27262 | — |
| Cara Therapeutics Study Site | Columbus | Ohio | 43215 | — |
| Cara Therapeutics Study Site | Charleston | South Carolina | 29407 | — |
| Cara Therapeutics Study Site | Bellaire | Texas | 77401 | — |
| Cara Therapeutics Study Site | Pflugerville | Texas | 78660 | — |
| Cara Therapeutics Study Site | San Antonio | Texas | 78213 | — |
| Cara Therapeutics Study Site | Salt Lake City | Utah | 84117 | — |
| Cara Therapeutics Study Site | Norfolk | Virginia | 23502 | — |
| Cara Therapeutics Study Site | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04706975, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 22, 2023 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04706975 live on ClinicalTrials.gov.