Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes
Public ClinicalTrials.gov record NCT04707469. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Once-daily Oral Semaglutide 25 mg and 50 mg Compared With 14 mg in Subjects With Type 2 Diabetes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study compares three doses of once daily semaglutide tablets in people with type 2 diabetes who were previously treated with other oral anti-diabetic medicines. Participants will be initiated on the lowest starting dose of 3 mg and gradually increased until they reach the final trial dose of 14 mg, 25 mg or 50 mg once daily semaglutide tablets. The final three doses will be randomized (i.e., decided by chance). Participants will be administered one tablet per day for 68 weeks. Women cannot take part if they are pregnant, breast-feeding or planning to become pregnant during the study period. Women who can get pregnant will be checked for pregnancy via urine tests. Once daily semaglutide tablets (3 mg, 7 mg and 14 mg) are approved for the treatment of type 2 diabetes in the US, in the EU and in some other countries, under the brand name Rybelsus®.
Study identification
- NCT ID
- NCT04707469
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,606 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 14, 2021
- Primary completion
- Mar 6, 2023
- Completion
- Mar 7, 2023
- Last update posted
- Dec 8, 2025
2021 – 2023
United States locations
- U.S. sites
- 84
- U.S. states
- 30
- U.S. cities
- 77
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| American Clinical Trials | Buena Park | California | 90620 | — |
| Valley Research | Fresno | California | 93720 | — |
| Velocity Clin Res San Diego | La Mesa | California | 91942 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Velocity Clin Res Los Angeles | Los Angeles | California | 90017 | — |
| Diabetes Medical Center Of California | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Gateway Research Center | Poway | California | 92064 | — |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| San Fernando Valley Hlth Inst, LLC | West Hills | California | 91304 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Optumcare Clinical Trials,LLC-Golden | Colorado Springs | Colorado | 80906 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Alliance for Multispec Res | Coral Gables | Florida | 33134 | — |
| Northeast Research Institute | Jacksonville | Florida | 32204 | — |
| San Marcus Res Clin Miami Lakes | Miami Lakes | Florida | 33014 | — |
| Complete Health Research | Ormond Beach | Florida | 32174-6302 | — |
| Clinical Trial Res Assoc,Inc | Plantation | Florida | 33324 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| East West Med Res Inst | Honolulu | Hawaii | 96814 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Rocky Mt Clin Res, LLC | Idaho Falls | Idaho | 83404-7596 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Macoupin Research Group | Gillespie | Illinois | 62033 | — |
| UnityPoint Health-Diabetes Care Center | Peoria | Illinois | 61603 | — |
| Evanston Premier Hlthcr Res | Skokie | Illinois | 60077 | — |
| Midwest Inst For Clin Res | Indianapolis | Indiana | 46260 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Pennington Biom Res Ctr | Baton Rouge | Louisiana | 70808 | — |
| Centex Studies, Inc._Lake Charles | Lake Charles | Louisiana | 70601 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115-5804 | — |
| MassResearch, LLC | Waltham | Massachusetts | 02453 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098 | — |
| Mercury Str Med Grp, PLLC | Butte | Montana | 59701 | — |
| Univ of Nebraska Medical CTR | Omaha | Nebraska | 68198-3020 | — |
| University of Nebraska Medical Center-Diabetes Center | Omaha | Nebraska | 68198-4120 | — |
| Premier Research Inc. | Trenton | New Jersey | 08611 | — |
| UNC Diabetes Care Center_Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Rapid Medical Research Inc | Cleveland | Ohio | 44122 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| Albert J Weisbrot | Mason | Ohio | 45040 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Corvallis Clinic PC Clinical Research Department | Corvallis | Oregon | 97330-3737 | — |
| Preferred Primary Care Physicians_Pittsburgh | Pittsburgh | Pennsylvania | 15236 | — |
| Palmetto Clinical Research | Greenville | South Carolina | 29615 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Holston Medical Group Pc | Bristol | Tennessee | 37620-7352 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Murphy Research Center | Humboldt | Tennessee | 38343 | — |
| Clinical Neuroscience Solutions | Memphis | Tennessee | 38119 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| Velocity Clinical Research, Dallas | Dallas | Texas | 75230 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| Care United Research, LLC | Forney | Texas | 75126 | — |
| JCCT- Juno NW Houston | Houston | Texas | 77040 | — |
| JCCT- Juno NW Houston | Houston | Texas | 77074 | — |
| Southwest Clinical Trials | Houston | Texas | 77074 | — |
| Family Practice Care Associates | Humble | Texas | 77338 | — |
| Research Trials Worldwide LLC | Humble | Texas | 77338 | — |
| Juno Research, LLC_Cary | Katy | Texas | 77450 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Research Institute Of Dallas | Plano | Texas | 75093 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| VIP Trials | San Antonio | Texas | 78231 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Health Res of Hampton Roads | Newport News | Virginia | 23606 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
| Dominion Medical Associates | Richmond | Virginia | 23219 | — |
| Capital Clin Res Ctr,LLC | Olympia | Washington | 98502 | — |
| Wenatchee Valley Hospital and Clinics | Wenatchee | Washington | 98801-2028 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 144 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04707469, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 8, 2025 · Synced Sep 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04707469 live on ClinicalTrials.gov.