A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
Public ClinicalTrials.gov record NCT04714320. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor of Angiotensinogen Production Administered Subcutaneously for 12 Weeks to Hypertensive Patients With Uncontrolled Blood Pressure
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study was to evaluate the effect of IONIS-AGT-LRx compared to placebo on seated automated office systolic blood pressure (SBP) from baseline to Study Day 85 in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications and to evaluate the effect of IONIS-AGT-LRx on ambulatory blood pressure, seated automated office SBP, seated automated office diastolic blood pressure (DBP), and plasma angiotensinogen (AGT) at each scheduled visit in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications.
Study identification
- NCT ID
- NCT04714320
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 160 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2021 (Actual)
- Primary completion
- Jun 29, 2022 (Actual)
- Completion
- Oct 3, 2022 (Actual)
- Last update posted
- Feb 18, 2025
2021 – 2022
United States locations
- U.S. sites
- 48
- U.S. states
- 20
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Central Research Associates, Inc. | Birmingham | Alabama | 35205 | — |
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Cahaba Research, Inc. | Pelham | Alabama | 35124 | — |
| Syed Research Consultants LLC | Sheffield | Alabama | 35660 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| Advanced Research Center | Anaheim | California | 92805 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| RESPIRE Research | La Mesa | California | 91942 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Catalina Research Institute | Montclair | California | 91763 | — |
| San Fernando Valley Health Institute | Van Nuys | California | 91405 | — |
| Creekside Endocrine Associates, PC | Denver | Colorado | 80246 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| ALL Medical Research, LLC | Cooper City | Florida | 33024 | — |
| Nature Coast Clinical Research - Crystal River | Crystal River | Florida | 34429 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| Canvas Clinical Research | Lake Worth | Florida | 33467 | — |
| Allied Biomedical Research Institute, Inc. | Miami | Florida | 33155 | — |
| AMPM Research Clinic | Miami Gardens | Florida | 33169 | — |
| Advanced Research Institute Inc | New Port Richey | Florida | 34653 | — |
| Ocala Research Institute | Ocala | Florida | 34471 | — |
| Progressive Medical Research | Port Orange | Florida | 32124 | — |
| Gwinnett Research Institute | Buford | Georgia | 30519 | — |
| Sandhill Research, LLC | Decatur | Georgia | 30030 | — |
| Georgia Institute for Clinical Research | Marietta | Georgia | 30060 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621 | — |
| Clinical Investigation Specialists, Inc. - Wauconda | Wauconda | Illinois | 60084 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| Louisiana Heart Center | Slidell | Louisiana | 70458 | — |
| Clinical Trials of America, LLC - Monroe, LA | West Monroe | Louisiana | 71291 | — |
| BioPharm Clinical Research | Caro | Michigan | 48723 | — |
| Palm Research Center, Inc. | Las Vegas | Nevada | 89148 | — |
| NY Scientific | Brooklyn | New York | 11235 | — |
| Summit Research Group, LLC | Stow | Ohio | 44224 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| Health Concepts Research | Rapid City | South Dakota | 57702 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| North Texas Research Associates | Allen | Texas | 75013 | — |
| Juno Research, LL | Houston | Texas | 77040 | — |
| Protenium Clinical Research, LLC | Hurst | Texas | 76054 | — |
| Laguna Clinical Research Associates | Laredo | Texas | 78041 | — |
| Kalo Clinical Research | Salt Lake City | Utah | 84102 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23510 | — |
| TPMG Clinical Research | Williamsburg | Virginia | 23188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04714320, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 18, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04714320 live on ClinicalTrials.gov.