A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
Public ClinicalTrials.gov record NCT04714320. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor of Angiotensinogen Production Administered Subcutaneously for 12 Weeks to Hypertensive Patients With Uncontrolled Blood Pressure
Study identification
- NCT ID
- NCT04714320
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 160 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- IONIS-AGT-LRx Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 27, 2021
- Primary completion
- Jun 28, 2022
- Completion
- Oct 2, 2022
- Last update posted
- Feb 17, 2025
2021 – 2022
United States locations
- U.S. sites
- 48
- U.S. states
- 20
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Central Research Associates, Inc. | Birmingham | Alabama | 35205 | — |
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Cahaba Research, Inc. | Pelham | Alabama | 35124 | — |
| Syed Research Consultants LLC | Sheffield | Alabama | 35660 | — |
| Cardiology and Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| Advanced Research Center | Anaheim | California | 92805 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| RESPIRE Research | La Mesa | California | 91942 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Catalina Research Institute | Montclair | California | 91763 | — |
| San Fernando Valley Health Institute | Van Nuys | California | 91405 | — |
| Creekside Endocrine Associates, PC | Denver | Colorado | 80246 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| ALL Medical Research, LLC | Cooper City | Florida | 33024 | — |
| Nature Coast Clinical Research - Crystal River | Crystal River | Florida | 34429 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| Canvas Clinical Research | Lake Worth | Florida | 33467 | — |
| Allied Biomedical Research Institute, Inc. | Miami | Florida | 33155 | — |
| AMPM Research Clinic | Miami Gardens | Florida | 33169 | — |
| Advanced Research Institute Inc | New Port Richey | Florida | 34653 | — |
| Ocala Research Institute | Ocala | Florida | 34471 | — |
| Progressive Medical Research | Port Orange | Florida | 32124 | — |
| Gwinnett Research Institute | Buford | Georgia | 30519 | — |
| Sandhill Research, LLC | Decatur | Georgia | 30030 | — |
| Georgia Institute for Clinical Research | Marietta | Georgia | 30060 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621 | — |
| Clinical Investigation Specialists, Inc. - Wauconda | Wauconda | Illinois | 60084 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| Louisiana Heart Center | Slidell | Louisiana | 70458 | — |
| Clinical Trials of America, LLC - Monroe, LA | West Monroe | Louisiana | 71291 | — |
| BioPharm Clinical Research | Caro | Michigan | 48723 | — |
| Palm Research Center, Inc. | Las Vegas | Nevada | 89148 | — |
| NY Scientific | Brooklyn | New York | 11235 | — |
| Summit Research Group, LLC | Stow | Ohio | 44224 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| Health Concepts Research | Rapid City | South Dakota | 57702 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| North Texas Research Associates | Allen | Texas | 75013 | — |
| Juno Research, LL | Houston | Texas | 77040 | — |
| Protenium Clinical Research, LLC | Hurst | Texas | 76054 | — |
| Laguna Clinical Research Associates | Laredo | Texas | 78041 | — |
| Kalo Clinical Research | Salt Lake City | Utah | 84102 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23510 | — |
| TPMG Clinical Research | Williamsburg | Virginia | 23188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04714320, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 17, 2025 · Synced Jul 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04714320 live on ClinicalTrials.gov.