Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)
Public ClinicalTrials.gov record NCT04724837. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Multicentre, Randomised, Double-Blind, Active-Controlled, Parallel Group Dose-Ranging Study to Assess the Efficacy, Safety and Tolerability of Zibotentan and Dapagliflozin in Patients With Chronic Kidney Disease With Estimated Glomerular Filtration Rate (eGFR) ≥ 20 mL/Min/1.73 m^2
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to assess efficacy, safety and tolerability of treatment with zibotentan and dapagliflozin in combination and dapagliflozin 10 mg as monotherapy in participants with chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) ≥ 20 mL/min/1.73 m\^2, and urinary albumin to creatinine ratio (UACR) ≥ 150 mg/g and ≤ 5000 mg/g.
Study identification
- NCT ID
- NCT04724837
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 542 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2021 (Actual)
- Primary completion
- Jun 1, 2023 (Actual)
- Completion
- Jun 1, 2023 (Actual)
- Last update posted
- Jul 30, 2024
2021 – 2023
United States locations
- U.S. sites
- 50
- U.S. states
- 18
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Huntsville | Alabama | 35805 | — |
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Downey | California | 90242 | — |
| Research Site | Fountain Valley | California | 92708 | — |
| Research Site | Laguna Hills | California | 92653 | — |
| Research Site | Los Angeles | California | 90057 | — |
| Research Site | Northridge | California | 91324 | — |
| Research Site | Ontario | California | 91762 | — |
| Research Site | South Gate | California | 90280 | — |
| Research Site | Tarzana | California | 91356 | — |
| Research Site | Vacaville | California | 95687 | — |
| Research Site | Fort Lauderdale | Florida | 33308 | — |
| Research Site | Hialeah | Florida | 33012 | — |
| Research Site | New Port Richey | Florida | 34652 | — |
| Research Site | Orlando | Florida | 32806 | — |
| Research Site | Riverview | Florida | 33578 | — |
| Research Site | Tampa | Florida | 33614 | — |
| Research Site | Augusta | Georgia | 30904 | — |
| Research Site | Fayetteville | Georgia | 30214 | — |
| Research Site | Wichita | Kansas | 67214-2943 | — |
| Research Site | Owensboro | Kentucky | 42303 | — |
| Research Site | Metairie | Louisiana | 70006 | — |
| Research Site | Shreveport | Louisiana | 71101 | — |
| Research Site | Boston | Massachusetts | 02215 | — |
| Research Site | Flint | Michigan | 48504 | — |
| Research Site | Flint | Michigan | 48532 | — |
| Research Site | Lincoln | Nebraska | 68510 | — |
| Research Site | Las Vegas | Nevada | 89128 | — |
| Research Site | Greenville | North Carolina | 27834 | — |
| Research Site | Jacksonville | North Carolina | 28546 | — |
| Research Site | Kinston | North Carolina | 28504 | — |
| Research Site | Morehead City | North Carolina | 28557 | — |
| Research Site | New Bern | North Carolina | 28562 | — |
| Research Site | Wilmington | North Carolina | 28401 | — |
| Research Site | Marion | Ohio | 43302 | — |
| Research Site | Chester | Pennsylvania | 19013 | — |
| Research Site | Memphis | Tennessee | 38104 | — |
| Research Site | Memphis | Tennessee | 38119 | — |
| Research Site | Arlington | Texas | 76002 | — |
| Research Site | Conroe | Texas | 77384 | — |
| Research Site | Corpus Christi | Texas | 78414 | — |
| Research Site | El Paso | Texas | 79935 | — |
| Research Site | Houston | Texas | 77004 | — |
| Research Site | Houston | Texas | 77099 | — |
| Research Site | Odessa | Texas | 79761 | — |
| Research Site | San Antonio | Texas | 78212 | — |
| Research Site | Waxahachie | Texas | 75165 | — |
| Research Site | Forest | Virginia | 24551 | — |
| Research Site | Newport News | Virginia | 23606 | — |
| Research Site | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04724837, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2024 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04724837 live on ClinicalTrials.gov.