Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
Public ClinicalTrials.gov record NCT04727528. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind Randomized Placebo-controlled Parallel Design Multicenter Phase IIIb Study of the Effect of Sodium Zirconium Cyclosilicate (SZC) on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease (NEUTRALIZE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of this study is to evaluate the efficacy of SZC as compared to placebo in maintaining normal sK+ in patients with hyperkalemia and metabolic acidosis associated with CKD
Study identification
- NCT ID
- NCT04727528
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 39 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 22, 2021 (Actual)
- Primary completion
- Sep 14, 2022 (Actual)
- Completion
- Sep 14, 2022 (Actual)
- Last update posted
- Oct 6, 2023
2021 – 2022
United States locations
- U.S. sites
- 29
- U.S. states
- 17
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Florence | Alabama | 35630 | — |
| Research Site | Chula Vista | California | 91910 | — |
| Research Site | Downey | California | 90242 | — |
| Research Site | El Centro | California | 92243 | — |
| Research Site | South Gate | California | 90280 | — |
| Research Site | Victorville | California | 92395 | — |
| Research Site | Aurora | Colorado | 80045 | — |
| Research Site | Denver | Colorado | 80230 | — |
| Research Site | Coral Gables | Florida | 33134 | — |
| Research Site | Columbus | Georgia | 31904 | — |
| Research Site | Hinsdale | Illinois | 60521 | — |
| Research Site | Kansas City | Missouri | 64111 | — |
| Research Site | Las Vegas | Nevada | 89128 | — |
| Research Site | The Bronx | New York | 10461 | — |
| Research Site | Asheville | North Carolina | 28801 | — |
| Research Site | New Bern | North Carolina | 28562 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Providence | Rhode Island | 02903 | — |
| Research Site | Spartanburg | South Carolina | 29306 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Memphis | Tennessee | 38163 | — |
| Research Site | Dallas | Texas | 75230 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | San Antonio | Texas | 78258 | — |
| Research Site | Shenandoah | Texas | 77384 | — |
| Research Site | Alexandria | Virginia | 22304 | — |
| Research Site | Norfolk | Virginia | 23510 | — |
| Research Site | Bellevue | Washington | 98004 | — |
| Research Site | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04727528, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2023 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04727528 live on ClinicalTrials.gov.