A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease
Public ClinicalTrials.gov record NCT04734197. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Masked Study To Evaluate The Safety, Tolerability, And Efficacy Of SURF-100 Ophthalmic Solution (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination) In Subjects With Dry Eye Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
SURF-100 is being studied for the treatment of dry eye disease. SURF-100 is an investigational drug (which means the study drug is currently being tested) in the form of a sterile eye drop. The purpose of this research study is to see how well SURF-100 works to treat dry eye and what potential side effects there are, and to compare it with Vehicle (placebo), 0.1% mycophenolic acid (MPA) in Vehicle, 0.3% MPA in Vehicle, 0.01% betamethasone phosphate (BSP) in Vehicle, Restasis and Xiidra. This study will involve about 280-350 study participants age 18 and older at about 40 different research sites in the United States.
Study identification
- NCT ID
- NCT04734197
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 349 participants
Conditions and interventions
Conditions
Interventions
- SURF-100 (Combination of 0.3% Mycophenolic Acid and 0.01% Betamethasone Sodium Phosphate) Drug
- Mycophenolic Acid 0.1% Drug
- Mycophenolic Acid 0.3% Drug
- Betamethasone Sodium Phosphate 0.01% Drug
- Placebo Comparator: Vehicle Drug
- Cyclosporine 0.05% Ophthalmic Emulsion Drug
- Lifitegrast 5% Ophthalmic Solution Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 11, 2021 (Actual)
- Primary completion
- Mar 25, 2022 (Actual)
- Completion
- Mar 25, 2022 (Actual)
- Last update posted
- May 11, 2025
2021 – 2022
United States locations
- U.S. sites
- 40
- U.S. states
- 17
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cornea and Cataract Consultants of Arizona PC | Phoenix | Arizona | 85032 | — |
| Canyon City EyeCare | Azusa | California | 91702 | — |
| Inland Eye Specialists | Hemet | California | 92545 | — |
| North Valley Eye Medical Group Inc. | Mission Hills | California | 91345 | — |
| LoBue Laser and Eye Medical Center | Murrieta | California | 92562 | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Martel Eye Medical Group | Rancho Cordova | California | 95670 | — |
| Sacramento Eye Consultants, A Medical Corporation | Sacramento | California | 95815 | — |
| The Eye Center of Northern Colorado | Fort Collins | Colorado | 80528 | — |
| Connecticut Eye Consultants, PC | Danbury | Connecticut | 06810 | — |
| Florida Eye Microsurgical Institute, Inc. | Boynton Beach | Florida | 33426 | — |
| Hernando Eye Institute | Brooksville | Florida | 34613 | — |
| Bowden Eye and Associates | Jacksonville | Florida | 32256 | — |
| Eye Center of North Florida PA | Panama City | Florida | 32405 | — |
| International Research Center | Tampa | Florida | 33603 | — |
| Blue Ocean Clinical Research at The Macula Center | The Villages | Florida | 32162 | — |
| Coastal Research Associates, LLC | Roswell | Georgia | 30076 | — |
| Jackson Eye | Lake Villa | Illinois | 60046 | — |
| Cincinnati Eye Institute | Edgewood | Kentucky | 41017 | — |
| Kentucky Eye Institute | Lexington | Kentucky | 40517 | — |
| Midwest Vision Research Foundation at Pepose Vision Institute | Chesterfield | Missouri | 63017 | — |
| Tauber Eye Center | Kansas City | Missouri | 64111 | — |
| Tekwani Vision Center | St Louis | Missouri | 63128 | — |
| Ophthalmology Consultants Ltd. | St Louis | Missouri | 63131 | — |
| EyeSight Ophthalmic Services | Somersworth | New Hampshire | 03878 | — |
| Alterman, Modi & Wolter | Poughkeepsie | New York | 12603 | — |
| Rochester Ophthalmological Group, PC | Rochester | New York | 14618 | — |
| Physicians Protocol | Greensboro | North Carolina | 27401 | — |
| Scott & Christie and Associates, PC | Cranberry Township | Pennsylvania | 16066 | — |
| Black Hills Regional Eye Institute | Rapid City | South Dakota | 57701 | — |
| Total Eye Care, PA | Memphis | Tennessee | 38119 | — |
| VRF Eye Specialty Group | Memphis | Tennessee | 38120 | — |
| West TN EyeCare dba Toyos Clinic | Nashville | Tennessee | 37215 | — |
| Texan Eye Care, PA - Keystone Research, Ltd | Austin | Texas | 78731 | — |
| Houston Eye Associates | Houston | Texas | 77025 | — |
| Advanced Laser Vision & Surgical Institute | Houston | Texas | 77034 | — |
| Eye Clinics of South Texas, PA | San Antonio | Texas | 78209 | — |
| R and R Eye Research, LLC | San Antonio | Texas | 78229 | — |
| Tanner Clinic | Layton | Utah | 84041 | — |
| The Eye Institute of Utah | Salt Lake City | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04734197, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 11, 2025 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04734197 live on ClinicalTrials.gov.