OPT-302 With Ranibizumab in Neovascular Age-related Macular Degeneration (nAMD)
Public ClinicalTrials.gov record NCT04757610. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination With Ranibizumab, Compared With Ranibizumab Alone, in Participants With nAMD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A 2-year, phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.
Study identification
- NCT ID
- NCT04757610
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 986 participants
Conditions and interventions
Conditions
Interventions
- 2.0 mg OPT-302 Biological
- 0.5 mg ranibizumab Biological
- Sham Procedure
Biological · Procedure
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 12, 2021 (Actual)
- Primary completion
- Mar 31, 2025 (Actual)
- Completion
- Mar 31, 2025 (Actual)
- Last update posted
- Jul 22, 2025
2021 – 2025
United States locations
- U.S. sites
- 76
- U.S. states
- 24
- U.S. cities
- 70
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ShORe Investigational Site | Phoenix | Arizona | 85016 | — |
| ShORe Investigational Site | Phoenix | Arizona | 85050 | — |
| ShORe Investigational Site | Tucson | Arizona | 85704 | — |
| ShORe Investigational Site | Bakersfield | California | 93309 | — |
| ShORe Investigational Site | Campbell | California | 95008 | — |
| ShORe Investigational Site | Encino | California | 91436 | — |
| ShORe Investigational Site | Fullerton | California | 92835 | — |
| ShORe Investigational Site | Glendale | California | 91203 | — |
| ShORe Investigational Site | Huntington Beach | California | 92647 | — |
| ShORe Investigational Site | Laguna Hills | California | 92653 | — |
| ShORe Investigational Site | Long Beach | California | 90807 | — |
| ShORe Investigational Site | Los Angeles | California | 95817 | — |
| ShORe Investigational Site | Mountain View | California | 94040 | — |
| ShORe Investigational Site | Palm Desert | California | 92211 | — |
| ShORe Investigational site | Pasadena | California | 91107 | — |
| ShORe Investiagtional Site | Poway | California | 92064 | — |
| ShORe Investigational Site | Redlands | California | 92373 | — |
| ShORe Investigational Site | Sacramento | California | 95817 | — |
| ShORe Investigational Site | Santa Ana | California | 92705 | — |
| ShORe Investigational Site | Torrance | California | 90503 | — |
| ShORe Investigational Site | Colorado Springs | Colorado | 80909 | — |
| ShORe Investigational Site | Denver | Colorado | 80206 | — |
| ShORe Investigational Site | Lakewood | Colorado | 80228 | — |
| ShORe Investigational Site | Longmont | Colorado | 80503 | — |
| ShORe Investigational Site | Clearwater | Florida | 33761 | — |
| ShORe Investigational Site | Fort Lauderdale | Florida | 33308 | — |
| ShORe Investigational Site | Fort Myers | Florida | 33912 | — |
| ShORe Investigational Site | Gainesville | Florida | 32607 | — |
| ShORe Investigational Site | Lakeland | Florida | 33805 | — |
| ShORe Investigational Site | Pensacola | Florida | 32503 | — |
| ShORe Investigational Site | Pinellas Park | Florida | 33782 | — |
| ShORe Investigational Site | Temple Terrace | Florida | 33617 | — |
| ShORe Investigational Site | Augusta | Georgia | 30909 | — |
| ShORe Investigational Site | Sandy Springs | Georgia | 30328 | — |
| ShORe Investigational Site | Lemont | Illinois | 60439 | — |
| ShORe Investigational Site | Indianapolis | Indiana | 46290 | — |
| ShORe Investigational Site | Baltimore | Maryland | 21209 | — |
| ShORe Investigational Site | Baltimore | Maryland | 21237 | — |
| ShORe Investigational Site | Hagerstown | Maryland | 21740 | — |
| ShORe Investigational Site | Towson | Maryland | 21204 | — |
| ShORe Investigational Site | Springfield | Massachusetts | 01107 | — |
| ShORe Investigational Site | Minneapolis | Minnesota | 55416 | — |
| ShORe Investigational Site | St Louis | Missouri | 63108 | — |
| ShORe Investigational Site | Reno | Nevada | 89502 | — |
| ShORe Investigational Site | Bloomfield | New Jersey | 07003 | — |
| ShORe Investigational Site | Toms River | New Jersey | 08755 | — |
| ShORe Investigational Site | Hauppauge | New York | 11021 | — |
| ShORe Investigational Site | Liverpool | New York | 13088 | — |
| ShORe Investigational Site | Wake Forest | North Carolina | 27587 | — |
| ShORe Investigational Site | Fargo | North Dakota | 58104 | — |
| ShORe Investigational Site | Edmond | Oklahoma | 73013 | — |
| ShORe Investigational Site | Tulsa | Oklahoma | 74114 | — |
| ShORe Investigational Site | Eugene | Oregon | 97401 | — |
| ShORe Investigational Site | Portland | Oregon | 97225 | — |
| ShORe Investigational Site | Portland | Oregon | 97239 | — |
| ShORe Investigational Site | Salem | Oregon | 97302 | — |
| ShORe Investigational Site | Erie | Pennsylvania | 16507 | — |
| ShORe Investigational Site | Beaufort | South Carolina | 29902 | — |
| ShORe Investigational Site | Ladson | South Carolina | 29456 | — |
| ShORe Investigational Site | Nashville | Tennessee | 37203 | — |
| ShORe Investigational Site | Arlington | Texas | 76012 | — |
| ShORe Investigational Site | Austin | Texas | 78705 | — |
| ShORe Investigational Site | Austin | Texas | 78731 | — |
| ShORe Investigational Site | Bellaire | Texas | 77401 | — |
| ShORe Investigational Site | Dallas | Texas | 75231 | — |
| ShORe Investigational Site | Houston | Texas | 77030 | — |
| ShORe Investigational Site | Katy | Texas | 77494 | — |
| ShORe Investigational Site | McAllen | Texas | 78503 | — |
| ShORe Investigational Site | San Antonio | Texas | 78240 | — |
| ShORe Investigational Site | San Antonio | Texas | 78251 | — |
| ShORe Investigational Site | San Antonio | Texas | 78340 | — |
| ShORe Investigational Site | Tyler | Texas | 75701 | — |
| ShORe Investigational Site | Willow Park | Texas | 76087 | — |
| ShORe Investigational Site | Salt Lake City | Utah | 84107 | — |
| ShORe Investigational Site | Charlottesville | Virginia | 22903 | — |
| ShORe Investigational Site | Lynchburg | Virginia | 24502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 115 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04757610, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2025 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04757610 live on ClinicalTrials.gov.