OPT-302 With Aflibercept in Neovascular Age-related Macular Degeneration (nAMD)
Public ClinicalTrials.gov record NCT04757636. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination With Aflibercept, Compared With Aflibercept Alone, in Participants With nAMD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A 2-year phase 3, multicentre, randomised, parallel-group, sham-controlled, double-masked study. Primary efficacy will be determined at Week 52.
Study identification
- NCT ID
- NCT04757636
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 998 participants
Conditions and interventions
Conditions
Interventions
- 2.0 mg OPT-302 Biological
- 2.0 aflibercept Biological
- Sham Procedure
Biological · Procedure
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 12, 2021 (Actual)
- Primary completion
- Mar 31, 2025 (Actual)
- Completion
- Mar 31, 2025 (Actual)
- Last update posted
- Aug 5, 2025
2021 – 2025
United States locations
- U.S. sites
- 60
- U.S. states
- 29
- U.S. cities
- 60
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| COAST Investigational Site | Phoenix | Arizona | 85053 | — |
| COAST Investigational Site | Arcadia | California | 91006 | — |
| COAST Investigational Site | Huntington Beach | California | 92647 | — |
| COAST Investigational Site | Redlands | California | 92374 | — |
| COAST Investigational Site | Sacramento | California | 95841 | — |
| COAST Investigational Site | Danbury | Connecticut | 06810 | — |
| COAST Investigational Site | Altamonte Springs | Florida | 32750 | — |
| COAST Investigational Site | Boynton Beach | Florida | 33426 | — |
| COAST Investigational Site | Coral Springs | Florida | 33067 | — |
| COAST Investigational Site | Melbourne | Florida | 32901 | — |
| COAST Investigational Site | Orlando | Florida | 32806 | — |
| COAST Investigational Site | Plantation | Florida | 33324 | — |
| COAST Investigational Site | Sarasota | Florida | 34239 | — |
| COAST Investigational Site | St. Petersburg | Florida | 33711 | — |
| COAST Investigational Site | Stuart | Florida | 34994 | — |
| COAST Investigational Site | Winter Haven | Florida | 33880 | — |
| COAST Investigational Site | Marietta | Georgia | 30060 | — |
| COAST Investigational Site | ‘Aiea | Hawaii | 96701 | — |
| COAST Investigational Site | Chicago | Illinois | 60611 | — |
| COAST Investigational Site | Springfield | Illinois | 62704 | — |
| COAST Investigational Site | Urbana | Illinois | 61822 | — |
| COAST Investigational Site | New Albany | Indiana | 47150 | — |
| COAST Investigational Site | Lenexa | Kansas | 66215 | — |
| COAST Investigational Site | Prairie Village | Kansas | 66208 | — |
| COAST Investigational Site | West Monroe | Louisiana | 71291 | — |
| COAST Investigational Site | Hagerstown | Maryland | 21740 | — |
| COAST Investigational Site | Owings Mills | Maryland | 21117 | — |
| COAST Investigational Site | Boston | Massachusetts | 02114 | — |
| COAST Investigational Site | Worcester | Massachusetts | 01605 | — |
| COAST Investigational Site | Jackson | Mississippi | 39202 | — |
| COAST Investigational Site | Independence | Missouri | 64055 | — |
| COAST Investigational Site | St Louis | Missouri | 63128 | — |
| COAST Investigational Site | Edison | New Jersey | 08820 | — |
| COAST Investigational Site | Albuquerque | New Mexico | 87109 | — |
| COAST Investigational site | Shirley | New York | 11967 | — |
| COAST Investigational Site | Asheville | North Carolina | 28803 | — |
| COAST Investigational Site | Wilmington | North Carolina | 28401 | — |
| COAST Investigational Site | Winston-Salem | North Carolina | 27157 | — |
| COAST Investigational Site | Cincinnati | Ohio | 45202 | — |
| COAST Investigational Site | Dayton | Ohio | 45459 | — |
| COAST Investigational Site | Oklahoma City | Oklahoma | 73102 | — |
| COAST Investigational Site | Springfield | Oregon | 97477 | — |
| COAST Investigational Site | Kingston | Pennsylvania | 18704 | — |
| COAST Investigational Site | Philadelphia | Pennsylvania | 19107 | — |
| COAST Investigational Site | Greenville | South Carolina | 29605 | — |
| COAST Investigational Site | West Columbia | South Carolina | 29169 | — |
| COAST Investigational Site | Rapid City | South Dakota | 57701 | — |
| COAST Investigational Site | Germantown | Tennessee | 38138 | — |
| COAST Investigational Site | Knoxville | Tennessee | 37922 | — |
| COAST Investigational Site | Abilene | Texas | 79606 | — |
| COAST Investigational Site | Austin | Texas | 78705 | — |
| COAST Investigational Site | Burleson | Texas | 76028 | — |
| COAST Investigational Site | Conroe | Texas | 77384 | — |
| COAST Investigational Site | Dallas | Texas | 75243 | — |
| COAST Investigational Site | Plano | Texas | 75075 | — |
| COAST Investigational Site | Round Rock | Texas | 78681 | — |
| COAST Investigational Site | Fairfax | Virginia | 22031 | — |
| COAST Investigational Site | Bellevue | Washington | 98004 | — |
| COAST Investigational Site | Spokane | Washington | 99204 | — |
| COAST Investigational Site | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 149 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04757636, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2025 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04757636 live on ClinicalTrials.gov.