A Study of E2027 in Participants With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) With or Without Amyloid Copathology
Public ClinicalTrials.gov record NCT04764669. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label Study To Evaluate the Pharmacodynamic Effects, Efficacy, Safety, and Tolerability of E2027 in Subjects With Dementia With Lewy Bodies or Parkinson's Disease Dementia With or Without Amyloid Copathology
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of study is to demonstrate the pharmacodynamic (PD) effects of E2027 on cerebrospinal fluid (CSF) cyclic guanosine monophosphate (cGMP) in participants with DLB and PDD with and without amyloid copathology after 9 weeks of treatment.
Study identification
- NCT ID
- NCT04764669
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 34 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2021 (Actual)
- Primary completion
- Dec 8, 2021 (Actual)
- Completion
- Jan 27, 2022 (Actual)
- Last update posted
- Sep 26, 2022
2021 – 2022
United States locations
- U.S. sites
- 13
- U.S. states
- 7
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Elias Research Associates (Allied Biomedical Research Institute) | Miami | Florida | 33155 | — |
| Napa Research | Pompano Beach | Florida | 33064 | — |
| University of South Florida, Department of Psychiatry and Behavioral Neurosciences | Tampa | Florida | 33613 | — |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | — |
| University of Kentucky, Dept of Neurology, Sanders Brown Center on Aging | Lexington | Kentucky | 40536 | — |
| Advanced Memory Research Institute of NJPC | Toms River | New Jersey | 08755 | — |
| Neurological Associates of Albany, PC | Albany | New York | 12208 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Neurology Diagnostics, Inc. | Dayton | Ohio | 45459 | — |
| Cleveland Clinic, Lou Ruvo Center for Brain Health at Lakewood Hospital | Lakewood | Ohio | 44107 | — |
| Summit Research Network (Oregon) Inc. | Portland | Oregon | 97210 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04764669, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 26, 2022 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04764669 live on ClinicalTrials.gov.