A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT
Public ClinicalTrials.gov record NCT04766892. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Exploratory, Open-label, Proof-of-concept, Phase 2a Study of Mavacamten (MYK-461) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Chronic Elevation of Cardiac Biomarkers
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2a proof-of-concept study to assess safety, tolerability, and preliminary efficacy of mavacamten treatment on biomarker levels in participants with heart failure with preserved ejection fraction (HFpEF) and elevation of NT-proBNP with or without elevation of cTnT. Data from this study will inform future study designs of mavacamten in patients with HFpEF.
Study identification
- NCT ID
- NCT04766892
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 30 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2021 (Actual)
- Primary completion
- Feb 26, 2024 (Actual)
- Completion
- Feb 26, 2024 (Actual)
- Last update posted
- Mar 20, 2025
2021 – 2024
United States locations
- U.S. sites
- 20
- U.S. states
- 15
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0028 | Birmingham | Alabama | 35249 | — |
| Local Institution - 0019 | Phoenix | Arizona | 85016 | — |
| Local Institution - 0011 | Tucson | Arizona | 85724 | — |
| Local Institution - 0005 | Los Angeles | California | 90027 | — |
| Local Institution - 0026 | San Francisco | California | 94158 | — |
| Local Institution - 0020 | Jacksonville | Florida | 32216 | — |
| Local Institution - 0014 | Miami | Florida | 33133 | — |
| Local Institution - 0018 | Atlanta | Georgia | 30322 | — |
| Local Institution - 0004 | Chicago | Illinois | 60611 | — |
| Local Institution - 0023 | Hazel Crest | Illinois | 60429 | — |
| Local Institution - 0017 | Slidell | Louisiana | 70458 | — |
| Local Institution - 0007 | Grand Rapids | Michigan | 49503 | — |
| Local Institution - 0012 | New York | New York | 10065 | — |
| Local Institution - 0003 | Durham | North Carolina | 27710 | — |
| Local Institution - 0016 | Oklahoma City | Oklahoma | 73135 | — |
| Local Institution - 0010 | Portland | Oregon | 97225 | — |
| Local Institution - 0001 | Portland | Oregon | 97239 | — |
| Local Institution - 0002 | Philadelphia | Pennsylvania | 19104 | — |
| Local Institution - 0008 | Charleston | South Carolina | 29425 | — |
| Local Institution - 0006 | Salt Lake City | Utah | 84112 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04766892, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 20, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04766892 live on ClinicalTrials.gov.