ClinicalTrials.gov record
A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)
ClinicalTrials.gov ID: NCT04777396
Public ClinicalTrials.gov record NCT04777396. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 16, 2026, 1:15 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomised Double-blind Placebo-controlled Clinical Trial Investigating the Effect and Safety of Oral Semaglutide in Subjects With Early Alzheimer´s Disease (EVOKE)
Study identification
- NCT ID
- NCT04777396
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 1,840 participants
Conditions and interventions
Conditions
Interventions
- Placebo (semaglutide) Drug
- Semagludtide Drug
Drug
Eligibility (public fields only)
- Age range
- 55 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 17, 2021
- Primary completion
- Sep 15, 2025
- Completion
- Jan 29, 2026
- Last update posted
- Apr 8, 2026
2021 – 2026
United States locations
- U.S. sites
- 96
- U.S. states
- 30
- U.S. cities
- 79
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Imaging Endpoints | Scottsdale | Arizona | 85258 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Tucson Neuroscience Research | Tucson | Arizona | 85710 | — |
| Advanced Research Center, Inc. | Anaheim | California | 92805 | — |
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | — |
| Pacific Research Network | Lemon Grove | California | 91945 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| ASCLEPES Research Centers, | Long Beach | California | 90807 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA_Los Angeles | Los Angeles | California | 90095 | — |
| Wr-Pri, Llc | Newport Beach | California | 92660 | — |
| Well Care Medical Center | Panorama City | California | 91402 | — |
| Cedars-Sinai Medical Center | Pasadena | California | 90048 | — |
| Sharp Neurocog Res Ctr | San Diego | California | 92123 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Calfornia Neurosc Resrch Med | Sherman Oaks | California | 91403 | — |
| Southern California Research LLC | Simi Valley | California | 93065 | — |
| Mountain Neurological Research Center, Inc. | Basalt | Colorado | 81621 | — |
| Denver Neurological Research | Denver | Colorado | 80210 | — |
| Mile High Research Center | Denver | Colorado | 80218 | — |
| Yale University | Fairfield | Connecticut | 06824 | — |
| Topaz Clinical Research | Apopka | Florida | 32703 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Visionary Investigators Network | Aventura | Florida | 33180 | — |
| K2 Medical Research - Winter Garden | Clermont | Florida | 34711 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Integrity Clinical Research, LLC | Doral | Florida | 33122 | — |
| Neuropsychiatric Research Cent | Fort Myers | Florida | 33912 | — |
| Finlay Medical Research Group | Greenacres City | Florida | 33467 | — |
| Indago Research & Health Center Inc. | Hialeah | Florida | 33012 | — |
| Hlth Cr Family Rehab & Res Ctr | Hialeah | Florida | 33015 | — |
| Galiz Research | Hialeah | Florida | 33016 | — |
| K2 The Villages | Lady Lake | Florida | 32159 | — |
| K2 Medical Research, Maitland | Maitland | Florida | 32751 | — |
| Hlth Cr Family Rehab & Res Ctr | Miami | Florida | 33015 | — |
| Premier Clin Res Inst, Inc. | Miami | Florida | 33122 | — |
| Premier Clinical Research Institute, Inc. | Miami | Florida | 33122 | — |
| Central Miami Medical Institute | Miami | Florida | 33125 | — |
| Novel Clinical Research Center, LLC | Miami | Florida | 33173 | — |
| IMIC, Inc- Medical Research | Miami | Florida | 33176 | — |
| The Neurology Research Group | Miami | Florida | 33176 | — |
| Visionary Inv Ntwrk_Miami | Miami | Florida | 33176 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Suncoast Clin Res Port Richey | New Port Richey | Florida | 34652 | — |
| Combined Research Orlando Phase I-IV | Orlando | Florida | 32807 | — |
| Headlands Research Orlando | Orlando | Florida | 32819 | — |
| Advanced Research Consultants, Inc. | Palm Beach Gardens | Florida | 33410 | — |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | — |
| The Roskamp Institute, Inc. | Sarasota | Florida | 34243 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Stedman Clinical Trials LLC | Tampa | Florida | 33613 | — |
| Palm Beach Neuro Premiere Res | West Palm Beach | Florida | 33407 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Center for Adv Res & Education | Gainesville | Georgia | 30501 | — |
| Hawaii Neuroscience, Memory Disorders Center | Honolulu | Hawaii | 96817 | — |
| Velocity Clinical Research, Meridian | Meridian | Idaho | 83642 | — |
| Velocity Clinical Research | Meridian | Idaho | 83642 | — |
| Cotton-O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| University of Kentucky_Lexington_0 | Lexington | Kentucky | 40504 | — |
| Northern Light Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| ActivMed Practice & Research LLC | Methuen | Massachusetts | 01844 | — |
| Bronson Lakeview Neurobehavioral Health | Paw Paw | Michigan | 49079 | — |
| HealthPartners Center for Memory and Aging | Saint Paul | Minnesota | 55130 | — |
| Hattiesburg Clinic | Hattiesburg | Mississippi | 39401 | — |
| Altea Research Institute | Las Vegas | Nevada | 89102 | — |
| Wr-Crcn, Llc | Las Vegas | Nevada | 89106 | — |
| Patient First MD,clinical Trials | Middletown | New Jersey | 07748 | — |
| Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Albuquerque neuroscience Inc | Albuquerque | New Mexico | 87109 | — |
| SPRI Clinical Trials, LLC | Brooklyn | New York | 11235 | — |
| Neurological Assoc Long Island | Lake Success | New York | 11042 | — |
| NYU Grossman School of Med | New York | New York | 10016 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| New Hope Clinical Research | Charlotte | North Carolina | 28211 | — |
| AMC Research, LLC | Matthews | North Carolina | 28105 | — |
| Insight Clinical Trials LLC | Beachwood | Ohio | 44122 | — |
| NeuroScience Research Center, LLC | Canton | Ohio | 44718 | — |
| Valley Medical Primary Care | Centerville | Ohio | 45459 | — |
| Central States Research, LLC | Tulsa | Oklahoma | 74136 | — |
| Summit Research Network Oregon Inc. | Portland | Oregon | 97210 | — |
| Neural Net Research, LLC | Portland | Oregon | 97225 | — |
| The Clinical Trial Center | Jenkintown | Pennsylvania | 19046 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| Lowcountry Center for Vet Res | Charleston | South Carolina | 29403 | — |
| Coastal Neurology | Port Royal | South Carolina | 29935 | — |
| Genesis Neuroscience Clinic | Knoxville | Tennessee | 37909 | — |
| Vanderbilt Medical Center | Nashville | Tennessee | 37212 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Univ Of Texas Hlth Science Cntr | Houston | Texas | 77054 | — |
| Glenn Biggs Inst-Alzhm Neuro | San Antonio | Texas | 78229 | — |
| Shirzadi Shahin, MD | Sugar Land | Texas | 77478 | — |
| Memory Clinic, Inc | Bennington | Vermont | 05201 | — |
| Integrated Neurology Services | Falls Church | Virginia | 22043 | — |
| National Clin Res Inc. | Richmond | Virginia | 23294 | — |
| Booth Gardner Parkinson's Cre | Kirkland | Washington | 98034 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 348 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04777396, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced May 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04777396 live on ClinicalTrials.gov.