ClinicalTrials.gov record
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)
ClinicalTrials.gov ID: NCT04793958
Public ClinicalTrials.gov record NCT04793958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase 3 Study of MRTX849 in Combination With Cetuximab Versus Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation With Disease Progression On or After Standard First-Line Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study CA239-0006 is an open-label, randomized Phase 3 clinical trial comparing the efficacy of MRTX849 administered in combination with cetuximab versus chemotherapy in the second-line treatment setting in patients with CRC with KRAS G12C mutation.
Study identification
- NCT ID
- NCT04793958
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 461 participants
Conditions and interventions
Interventions
- MRTX849 Drug
- Cetuximab Biological
- mFOLFOX6 Regimen Drug
- FOLFIRI Regimen Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 24, 2021 (Actual)
- Primary completion
- Jan 16, 2026 (Actual)
- Completion
- Oct 23, 2026 (Estimated)
- Last update posted
- Sep 28, 2026
2021 – 2026
United States locations
- U.S. sites
- 185
- U.S. states
- 33
- U.S. cities
- 125
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 010-855-E | Alabaster | Alabama | 35007 | — |
| Local Institution - 010-855-B | Bessemer | Alabama | 35022 | — |
| Local Institution - 010-855-D | Birmingham | Alabama | 35209 | — |
| Local Institution - 010-855-A | Birmingham | Alabama | 35211 | — |
| Local Institution - 010-855-F | Birmingham | Alabama | 35235 | — |
| Local Institution - 010-855-C | Birmingham | Alabama | 35243 | — |
| Local Institution - 010-855 | Birmingham | Alabama | 35243 | — |
| Local Institution - 010-996 | Gilbert | Arizona | 85234 | — |
| Local Institution - 010-566 | Goodyear | Arizona | 85338 | — |
| Local Institution - 010-989 | Phoenix | Arizona | 85054 | — |
| Local Institution - 010-978 | Springdale | Arkansas | 72762 | — |
| Local Institution - 010-573 | Bakersfield | California | 93309 | — |
| Local Institution - 010-979C | Chula Vista | California | 91911 | — |
| Local Institution - 010-980 | Fresno | California | 93701 | — |
| Local Institution - 010-851 | Fullerton | California | 92835 | — |
| Local Institution - 010-979A | La Mesa | California | 91942 | — |
| Local Institution - 010-958A | Los Angeles | California | 90033 | — |
| Local Institution - 010-958 | Los Angeles | California | 90033 | — |
| Local Institution - 010-551 | Los Angeles | California | 90048 | — |
| Local Institution - 010-847 | Newport Beach | California | 92663 | — |
| Local Institution - 010-563 | Redlands | California | 92373 | — |
| Local Institution - 010-979B | San Diego | California | 92123 | — |
| Local Institution - 010-979D | San Diego | California | 92123 | — |
| Local Institution - 010-979 | San Diego | California | 92123 | — |
| Local Institution - 010-982 | San Francisco | California | 94115 | — |
| Local Institution - 010-561 | Santa Monica | California | 90404 | — |
| Local Institution - 010-571 | Sylmar | California | 91342 | — |
| Local Institution - 010-574 | Torrance | California | 90505 | — |
| Local Institution - 010-570 | Whittier | California | 90602 | — |
| Local Institution - 010-872-H | Aurora | Colorado | 80012 | — |
| Local Institution - 010-810 | Aurora | Colorado | 80045 | — |
| Local Institution - 010-872-A | Boulder | Colorado | 80303 | — |
| Local Institution - 010-872-E | Centennial | Colorado | 80112 | — |
| Local Institution - 010-872-C | Colorado Springs | Colorado | 80907 | — |
| Local Institution - 010-872 | Denver | Colorado | 80218 | — |
| Local Institution - 010-872-B | Denver | Colorado | 80220 | — |
| Local Institution - 010-872-J | Lakewood | Colorado | 80228 | — |
| Local Institution - 010-872-F | Littleton | Colorado | 80218 | — |
| Local Institution - 010-872-G | Longmont | Colorado | 80501 | — |
| Local Institution - 010-872-I | Pueblo | Colorado | 81008 | — |
| Local Institution - 010-872-D | Thornton | Colorado | 80260 | — |
| Local Institution - 010-949 | Norwich | Connecticut | 06360 | — |
| Local Institution - 010-922-A | Bonita Springs | Florida | 34135 | — |
| Local Institution - 010-922-D | Bradenton | Florida | 34211 | — |
| Local Institution - 010-922-E | Cape Coral | Florida | 33909 | — |
| Local Institution - 010-922 | Fort Myers | Florida | 33901 | — |
| Local Institution - 010-922-B | Fort Myers | Florida | 33905 | — |
| Local Institution - 010-922-C | Fort Myers | Florida | 33908 | — |
| Local Institution - 010-984-B | Holiday | Florida | 34691 | — |
| Local Institution - 010-829 | Jacksonville | Florida | 32224 | — |
| Local Institution - 010-923-A | Largo | Florida | 33770 | — |
| Local Institution - 010-923-B | Largo | Florida | 33770 | — |
| Local Institution - 010-923-C | Largo | Florida | 33770 | — |
| Local Institution - 010-923-D | Largo | Florida | 33770 | — |
| Local Institution - 010-923-E | Largo | Florida | 33770 | — |
| Local Institution - 010-923-F | Largo | Florida | 33770 | — |
| Local Institution - 010-923-G | Largo | Florida | 33770 | — |
| Local Institution - 010-923-H | Largo | Florida | 33770 | — |
| Local Institution - 010-923-I | Largo | Florida | 33770 | — |
| Local Institution - 010-923-J | Largo | Florida | 33770 | — |
| Local Institution - 010-923-K | Largo | Florida | 33770 | — |
| Local Institution - 010-923-L | Largo | Florida | 33770 | — |
| Local Institution - 010-923-M | Largo | Florida | 33770 | — |
| Local Institution - 010-923-N | Largo | Florida | 33770 | — |
| Local Institution - 010-923-O | Largo | Florida | 33770 | — |
| Local Institution - 010-923-P | Largo | Florida | 33770 | — |
| Local Institution - 010-990 | Miami | Florida | 33136 | — |
| Local Institution - 010-922-F | Naples | Florida | 34102 | — |
| Local Institution - 010-922-G | Naples | Florida | 34102 | — |
| Local Institution - 010-538 | Ocala | Florida | 34474 | — |
| Local Institution - 010-896 | Orlando | Florida | 32804 | — |
| Local Institution - 010-988 | Orlando | Florida | 32806 | — |
| Local Institution - 010-922-H | Port Charlotte | Florida | 33980 | — |
| Local Institution - 010-923 | St. Petersburg | Florida | 33705 | — |
| Local Institution - 010-984 | St. Petersburg | Florida | 33709-2236 | — |
| Local Institution - 010-924 | Tallahassee | Florida | 32308 | — |
| Local Institution - 010-984-A | Trinity | Florida | 34655 | — |
| Local Institution - 010-926 | West Palm Beach | Florida | 33401 | — |
| Local Institution - 010-537 | Weston | Florida | 33331 | — |
| Local Institution - 010-956 | Atlanta | Georgia | 30322 | — |
| Local Institution - 010-986 | Newnan | Georgia | 30265 | — |
| Local Institution - 010-963 | Naperville | Illinois | 60540 | — |
| Local Institution - 010-994 | Zion | Illinois | 60099 | — |
| Local Institution - 010-569-A | Indianapolis | Indiana | 46237-8601 | — |
| Local Institution - 010-569 | Indianapolis | Indiana | 46237-8601 | — |
| Local Institution - 010-991 | Iowa City | Iowa | 52242 | — |
| Local Institution - 010-920 | Baton Rouge | Louisiana | 70809 | — |
| Local Institution - 010-534 | Baltimore | Maryland | 21201 | — |
| Local Institution - 010-997 | Boston | Massachusetts | 02215 | — |
| Local Institution - 010-531A | Brownstown | Michigan | 48183 | — |
| Local Institution - 010-531C | Dearborn | Michigan | 48126 | — |
| Local Institution - 010-531 | Detroit | Michigan | 48202 | — |
| Local Institution - 010-531B | Novi | Michigan | 48377 | — |
| Local Institution - 010-875 | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 010-830 | Rochester | Minnesota | 55905 | — |
| Local Institution - 010-838 | Saint Louis Park | Minnesota | 55416 | — |
| Local Institution - 010-838A | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838B | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838C | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838D | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838E | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838F | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838G | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838H | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838I | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838J | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838K | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838L | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-838M | Saint Louis Park | Minnesota | 55426 | — |
| Local Institution - 010-541 | Springfield | Missouri | 65804 | — |
| Local Institution - 010-564 | Lincoln | Nebraska | 68510 | — |
| Local Institution - 010-590 | Omaha | Nebraska | 68130 | — |
| Local Institution - 010-860 - A | Henderson | Nevada | 89052 | — |
| Local Institution - 010-860-F | Henderson | Nevada | 89052 | — |
| Local Institution - 010-860-B | Henderson | Nevada | 89074 | — |
| Local Institution - 010-860-D | Las Vegas | Nevada | 89128 | — |
| Local Institution - 010-860-C | Las Vegas | Nevada | 89144 | — |
| Local Institution - 010-860-E | Las Vegas | Nevada | 89148 | — |
| Local Institution - 010-860 | Las Vegas | Nevada | 89169 | — |
| Local Institution - 010-918 - B | Basking Ridge | New Jersey | 07920 | — |
| Local Institution - 010-993 | Belleville | New Jersey | 07109 | — |
| Local Institution - 010-975 | East Brunswick | New Jersey | 08816 | — |
| Local Institution - 010-992 | Florham Park | New Jersey | 07932 | — |
| Local Institution - 010-918 - D | Middletown | New Jersey | 07748 | — |
| Local Institution - 010-918 - C | Montvale | New Jersey | 07645 | — |
| Local Institution - 010-957 | New Brunswick | New Jersey | 08903-2681 | — |
| Local Institution - 010-535 - D | Babylon | New York | 11702 | — |
| Local Institution - 010-918 - A | Commack | New York | 11725 | — |
| Local Institution - 010-918 - F | Harrison | New York | 10604 | — |
| Local Institution - 010-813 | New York | New York | 10016 | — |
| Local Institution - 010-535 - G | New York | New York | 10028 | — |
| Local Institution - 010-998 | New York | New York | 10029 | — |
| Local Institution - 010-918 | New York | New York | 10065 | — |
| Local Institution - 010-535 - C | Patchogue | New York | 11772 | — |
| Local Institution - 010-535 - A | Port Jefferson | New York | 11776 | — |
| Local Institution - 010-535 - B | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 010-535 - F | Riverhead | New York | 11901 | — |
| Local Institution - 010-535 | Shirley | New York | 11967 | — |
| Local Institution - 010-535 - E | The Bronx | New York | 10469 | — |
| Local Institution - 010-918 - E | Uniondale | New York | 11553 | — |
| Local Institution - 010-585-B | Clinton | North Carolina | 28328 | — |
| Local Institution - 010-585 | Goldsboro | North Carolina | 27534 | — |
| Local Institution - 010-585-A | Jacksonville | North Carolina | 28546 | — |
| Local Institution - 010-893 | Cincinnati | Ohio | 45211 | — |
| Local Institution - 010-532 | Oklahoma City | Oklahoma | 73104 | — |
| Local Institution - 010-549 | Oklahoma City | Oklahoma | 73120 | — |
| Local Institution - 010-584 | Tulsa | Oklahoma | 74146 | — |
| Local Institution - 010-596 | Pittsburgh | Pennsylvania | 15212 | — |
| Local Institution - 010-981 | Greenville | South Carolina | 29607 | — |
| Local Institution - 010-921 | Chattanooga | Tennessee | 37404 | — |
| Local Institution - 010-801 | Nashville | Tennessee | 37203 | — |
| Local Institution - 010-572 | Dallas | Texas | 75216 | — |
| Local Institution - 010-879 | Dallas | Texas | 75246 | — |
| Local Institution - 010-577-B | Houston | Texas | 77008 | — |
| Local Institution - 010-577-A | Houston | Texas | 77024 | — |
| Local Institution - 010-577 | Houston | Texas | 77030 | — |
| Local Institution - 010-848 | Houston | Texas | 77030 | — |
| Local Institution - 010-977 | Houston | Texas | 77090 | — |
| Local Institution - 010-999 | Irving | Texas | 75063 | — |
| Local Institution - 010-878-B | Longview | Texas | 75601 | — |
| Local Institution - 010-862 | San Antonio | Texas | 78240 | — |
| Local Institution - 010-964 | Temple | Texas | 76508 | — |
| Local Institution - 010-878 | Tyler | Texas | 75702 | — |
| Local Institution - 010-976-F | American Fork | Utah | 84003 | — |
| Local Institution - 010-976-C | Bountiful | Utah | 84010 | — |
| Local Institution - 010-976-D | Layton | Utah | 84041 | — |
| Local Institution - 010-976-A | Murray | Utah | 84157 | — |
| Local Institution - 010-976-H | Ogden | Utah | 84405 | — |
| Local Institution - 010-976-G | Provo | Utah | 84604 | — |
| Local Institution - 010-976-B | Salt Lake City | Utah | 84102 | — |
| Local Institution - 010-976 | Salt Lake City | Utah | 84106 | — |
| Local Institution - 010-976-E | West Jordan | Utah | 84088 | — |
| Local Institution - 010-919 | Fairfax | Virginia | 22031-4630 | — |
| Local Institution - 010-597 | Fredericksburg | Virginia | 24408 | — |
| Local Institution - 010-539 | Richmond | Virginia | 23229 | — |
| Local Institution - 010-536 | Richmond | Virginia | 23298 | — |
| Local Institution - 010-533 A | Auburn | Washington | 98001 | — |
| Local Institution - 010-576 | Everett | Washington | 98201 | — |
| Local Institution - 010-533 B | Gig Harbor | Washington | 98335 | — |
| Local Institution - 010-533 C | Puyallup | Washington | 98372 | — |
| Local Institution - 010-824 | Seattle | Washington | 98109--1023 | — |
| Local Institution - 010-533 | Tacoma | Washington | 98405 | — |
| Local Institution - 010-885 | Vancouver | Washington | 98684 | — |
| Local Institution - 010-575 | Morgantown | West Virginia | 26506-9300 | — |
| Local Institution - 010-947 | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 234 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04793958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04793958 live on ClinicalTrials.gov.