Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis
Public ClinicalTrials.gov record NCT04804605. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Open-Label Extension Study of the Long-Term Safety of ARQ-151 Cream 0.15% and ARQ-151 Cream 0.05% in Subjects With Atopic Dermatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study was a Phase 3, multicenter, open-label extension study of the long-term safety of roflumilast cream 0.15% (completers of studies ARQ-151-311 or ARQ-151-312 aged ≥6 years and ARQ-151-315 rollovers who turned 6 years of age on study) or roflumilast cream 0.05% (ARQ-151-315 rollovers aged 2 to 5 years). Participants with mild to moderate atopic dermatitis (AD) applied roflumilast cream once daily (qd) for up to 52 weeks.
Study identification
- NCT ID
- NCT04804605
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,220 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 2 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2021 (Actual)
- Primary completion
- May 28, 2024 (Actual)
- Completion
- May 28, 2024 (Actual)
- Last update posted
- Dec 23, 2025
2021 – 2024
United States locations
- U.S. sites
- 76
- U.S. states
- 30
- U.S. cities
- 67
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arcutis Clinical Site 112 | Birmingham | Alabama | 35209 | — |
| Arcutis Clinical Site 73 | Birmingham | Alabama | 35244 | — |
| Arcutis Clinical Site 63 | Scottsdale | Arizona | 85255 | — |
| Arcutis Clinical Site 106 | Bryant | Arkansas | 72022 | — |
| Arcutis Clinical Site 116 | Fort Smith | Arkansas | 72916 | — |
| Arcutis Clinical Site 69 | Beverly Hills | California | 90212 | — |
| Arcutis Clinical Site 81 | Inglewood | California | 90301 | — |
| Clinical Site 08 | San Francisco | California | 94132 | — |
| Arcutis Clinical Site 31 | Santa Monica | California | 90404 | — |
| Arcutis Clinical Site 130 | Thousand Oaks | California | 91320 | — |
| Arcutis Clinical Site 123 | Centennial | Colorado | 80112 | — |
| Arcutis Clinical Site 59 | Coral Gables | Florida | 33134 | — |
| Arcutis Clinical Site 72 | Coral Gables | Florida | 33146 | — |
| Arcutis Clinical Site 79 | Delray Beach | Florida | 33484 | — |
| Arcutis Clinical Site 103 | Hollywood | Florida | 33021 | — |
| Clinical Site 04 | Jacksonville | Florida | 32256 | — |
| Arcutis Clinical Site 15 | Largo | Florida | 33770 | — |
| Arcutis Clinical Site 67 | Miami | Florida | 33162 | — |
| Arcutis Clinical Site 95 | Miami | Florida | 33173 | — |
| Arcutis Clinical Site 68 | Miami | Florida | 33174 | — |
| Arcutis Clinical Site 29 | Sanford | Florida | 32771 | — |
| Clinical Site 01 | Tampa | Florida | 33613 | — |
| Arcutis Clinical Site 138 | Wellington | Florida | 33449 | — |
| Arcutis Clinical Site 47 | Sandy Springs | Georgia | 30328 | — |
| Arcutis Clinical Site 145 | Boise | Idaho | 83706 | — |
| Arcutis Clinical Site 13 | Rolling Meadows | Illinois | 33770 | — |
| Arcutis Clinical Site 93 | Clarksville | Indiana | 47129 | — |
| Clinical Site 22 | Plainfield | Indiana | 46168 | — |
| Arcutis Clinical Site 114 | West Lafayette | Indiana | 47906 | — |
| Clinical Site 03 | Louisville | Kentucky | 40217 | — |
| Arcutis Clinical Site 80 | Covington | Louisiana | 70433 | — |
| Arcutis Clinical Site 85 | Lake Charles | Louisiana | 70605 | — |
| Arcutis Clinical Site 24 | Metairie | Louisiana | 70006 | — |
| Arcutis Clinical Site 76 | Rockville | Maryland | 20850 | — |
| Arcutis Clinical Site 94 | Bay City | Michigan | 48706 | — |
| Arcutis Clinical Site 88 | Clarkston | Michigan | 48346 | — |
| Arcutis Clinical Site 58 | Clinton Township | Michigan | 48038 | — |
| Arcutis Clinical Site 66 | Detroit | Michigan | 48202 | — |
| Arcutis Clinical Site 132 | Troy | Michigan | 48084 | — |
| Clinical Site 10 | New Brighton | Minnesota | 55112 | — |
| Arcutis Clinical Site 102 | Saint Joseph | Missouri | 64506 | — |
| Arcutis Clinical Site 62 | Reno | Nevada | 89509 | — |
| Arcutis Clinical Site 71 | East Windsor | New Jersey | 08520 | — |
| Arcutis Clinical Site 96 | Kew Gardens | New York | 11415 | — |
| Arcutis Clinical Site 82 | Rochester | New York | 14623 | — |
| Arcutis Clinical Site 19 | High Point | North Carolina | 27262 | — |
| Arcutis Clinical Site 17 | Gresham | Oregon | 97030 | — |
| Arcutis Clinical Site 108 | Portland | Oregon | 97210 | — |
| Arcutis Clinical Site 16 | Portland | Oregon | 97223 | — |
| Arcutis Clinical Site 14 | Portland | Oregon | 97239 | — |
| Arcutis Clinical Site 53 | Hershey | Pennsylvania | 17033 | — |
| Arcutis Clinical Site 64 | Newtown Square | Pennsylvania | 19073 | — |
| Arcutis Clinical Site 25 | Pittsburgh | Pennsylvania | 15213 | — |
| Arcutis Clinical Site 101 | Johnston | Rhode Island | 02919 | — |
| Arcutis Clinical Site 77 | Charleston | South Carolina | 29407 | — |
| Arcutis Clinical Site 41 | Charleston | South Carolina | 29425 | — |
| Clinical Site 33 | North Charleston | South Carolina | 29420 | — |
| Arcutis Clinical Site 91 | Summerville | South Carolina | 29486 | — |
| Arcutis Clinical Site 60 | Murfreesboro | Tennessee | 37130 | — |
| Arcutis Clinical Site 34 | Arlington | Texas | 76011 | — |
| Clinical Site 23 | Austin | Texas | 78759 | — |
| Arcutis Clinical Site 84 | Bellaire | Texas | 77401 | — |
| Arcutis Clinical Site 21 | College Station | Texas | 77845 | — |
| Arcutis Clinical Site 126 | Frisco | Texas | 75034 | — |
| Arcutis Clinical Site 118 | Grapevine | Texas | 76051 | — |
| Arcutis Clinical Site 48 | Houston | Texas | 77030 | — |
| Arcutis Clinical Site 35 | Houston | Texas | 77056 | — |
| Arcutis Clinical Site 109 | Katy | Texas | 77494 | — |
| Clinical Site 20 | San Antonio | Texas | 78213 | — |
| Arcutis Clinical Site 49 | San Antonio | Texas | 78218 | — |
| Arcutis Clinical Site 74 | Orem | Utah | 84058 | — |
| Arcutis Clinical Site 36 | West Jordan | Utah | 84088 | — |
| Arcutis Clinical Site 51 | Burke | Virginia | 22015 | — |
| Arcutis Clinical Site 40 | Norfolk | Virginia | 23502 | — |
| Arcutis Clinical Site 12 | Spokane | Washington | 99202 | — |
| Arcutis Clinical Site 133 | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04804605, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 23, 2025 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04804605 live on ClinicalTrials.gov.