Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

ClinicalTrials.gov ID: NCT04804644

Public ClinicalTrials.gov record NCT04804644. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:43 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases From Small Cell Lung Cancer

Study identification

NCT ID: NCT04804644
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: NRG Oncology; Other
Enrollment: 200 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Magnetic Resonance Imaging Procedure
Memantine Hydrochloride Drug
Neurocognitive Assessment Other
Stereotactic Radiosurgery Radiation
Survey Administration Other
Whole-Brain Radiotherapy Radiation

Procedure · Drug · Other + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 7, 2021
Primary completion: Jun 30, 2028
Completion: Jun 30, 2030
Last update posted: May 3, 2026

2021 – 2030

United States locations

U.S. sites: 223
U.S. states: 30
U.S. cities: 174

Facility	City	State	ZIP	Site status
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Active, not recruiting
Kaiser Permanente-Anaheim	Anaheim	California	92806	Recruiting
Kaiser Permanente-Bellflower	Bellflower	California	90706	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Kaiser Permanente-Ontario	Ontario	California	91761	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Active, not recruiting
UCHealth Memorial Hospital Central	Colorado Springs	Colorado	80909	Active, not recruiting
Memorial Hospital North	Colorado Springs	Colorado	80920	Active, not recruiting
Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	06830	Terminated
Smilow Cancer Hospital Care Center - Guilford	Guilford	Connecticut	06437	Terminated
Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	06510	Terminated
Yale University	New Haven	Connecticut	06520	Terminated
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Terminated
Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	06385	Terminated
Beebe Medical Center	Lewes	Delaware	19958	Active, not recruiting
Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	19713	Active, not recruiting
Helen F Graham Cancer Center	Newark	Delaware	19713	Active, not recruiting
Medical Oncology Hematology Consultants PA	Newark	Delaware	19713	Active, not recruiting
Christiana Care Health System-Christiana Hospital	Newark	Delaware	19718	Active, not recruiting
Beebe Health Campus	Rehoboth Beach	Delaware	19971	Active, not recruiting
Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	19801	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Active, not recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Active, not recruiting
Moffitt Cancer Center-International Plaza	Tampa	Florida	33607	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center at Wesley Chapel	Wesley Chapel	Florida	33544	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Active, not recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Active, not recruiting
Emory Saint Joseph's Hospital	Atlanta	Georgia	30342	Active, not recruiting
Northside Hospital	Atlanta	Georgia	30342	Recruiting
Northside Hospital-Cherokee	Canton	Georgia	30115	Recruiting
Northside Hospital-Forsyth	Cumming	Georgia	30041	Recruiting
Memorial Health University Medical Center	Savannah	Georgia	31404	Suspended
Rush-Copley Medical Center	Aurora	Illinois	60504	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Rush MD Anderson Cancer Center	Chicago	Illinois	60612	Active, not recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
HSHS Saint Elizabeth's Hospital	O'Fallon	Illinois	62269	Recruiting
OSF Saint Francis Medical Center	Peoria	Illinois	61637	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
The Carle Foundation Hospital	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
IU Health West Hospital	Avon	Indiana	46123	Recruiting
IU Health North Hospital	Carmel	Indiana	46032	Recruiting
Goshen Center for Cancer Care	Goshen	Indiana	46526	Recruiting
Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Recruiting
IU Health Methodist Hospital	Indianapolis	Indiana	46202	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
Baptist Health Lexington	Lexington	Kentucky	40503	Active, not recruiting
The James Graham Brown Cancer Center at University of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	70809	Recruiting
Luminis Health Anne Arundel Medical Center	Annapolis	Maryland	21401	Active, not recruiting
University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	21201	Recruiting
MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	21237	Suspended
UM Upper Chesapeake Medical Center	Bel Air	Maryland	21014	Recruiting
Central Maryland Radiation Oncology in Howard County	Columbia	Maryland	21044	Recruiting
University of Maryland Shore Medical Center at Easton	Easton	Maryland	21601	Recruiting
UM Baltimore Washington Medical Center/Tate Cancer Center	Glen Burnie	Maryland	21061	Recruiting
TidalHealth Richard A Henson Cancer Institute	Ocean Pines	Maryland	21811	Active, not recruiting
TidalHealth Peninsula Regional	Salisbury	Maryland	21801	Active, not recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor	Michigan	48106	Recruiting
McLaren Cancer Institute-Bay City	Bay City	Michigan	48706	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health Medical Center - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health Medical Center - Canton	Canton	Michigan	48188	Recruiting
Caro Cancer Center	Caro	Michigan	48723	Suspended
Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Recruiting
McLaren Cancer Institute-Flint	Flint	Michigan	48532	Recruiting
Karmanos Cancer Institute at McLaren Greater Lansing	Lansing	Michigan	48910	Recruiting
McLaren Cancer Institute-Lapeer Region	Lapeer	Michigan	48446	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	48453	Suspended
McLaren Cancer Institute-Macomb	Mount Clemens	Michigan	48043	Recruiting
McLaren Cancer Institute-Central Michigan	Mount Pleasant	Michigan	48858	Recruiting
McLaren Cancer Institute-Northern Michigan	Petoskey	Michigan	49770	Recruiting
McLaren-Port Huron	Port Huron	Michigan	48060	Recruiting
MyMichigan Medical Center Saginaw	Saginaw	Michigan	48601	Suspended
Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	48604	Suspended
MyMichigan Medical Center Tawas	Tawas City	Michigan	48764	Suspended
Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	48661	Suspended
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Minnesota Oncology - Burnsville	Burnsville	Minnesota	55337	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Unity Hospital	Fridley	Minnesota	55432	Active, not recruiting
Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	55369	Recruiting
Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	55109	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Monticello Cancer Center	Monticello	Minnesota	55362	Recruiting
Coborn Cancer Center at Saint Cloud Hospital	Saint Cloud	Minnesota	56303	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Lakeview Hospital	Stillwater	Minnesota	55082	Recruiting
Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	55125	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Parkland Health Center - Farmington	Farmington	Missouri	63640	Recruiting
Freeman Health System	Joplin	Missouri	64804	Recruiting
Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	63670	Recruiting
Mercy Hospital Springfield	Springfield	Missouri	65804	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
Missouri Baptist Sullivan Hospital	Sullivan	Missouri	63080	Recruiting
BJC Outpatient Center at Sunset Hills	Sunset Hills	Missouri	63127	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Suspended
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Suspended
Logan Health Medical Center	Kalispell	Montana	59901	Suspended
Cooper Hospital University Medical Center	Camden	New Jersey	08103	Recruiting
Sands Cancer Center	Canandiaqua	New York	14424	Active, not recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Active, not recruiting
Northern Westchester Hospital	Mount Kisco	New York	10549	Active, not recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	10032	Active, not recruiting
Upstate Cancer Center Radiation Oncology at Oswego	Oswego	New York	13126	Recruiting
Wilmot Cancer Institute Radiation Oncology at Greece	Rochester	New York	14606	Active, not recruiting
University of Rochester	Rochester	New York	14642	Active, not recruiting
State University of New York Upstate Medical University	Syracuse	New York	13210	Recruiting
Upstate Cancer Center at Hill Radiation Oncology	Syracuse	New York	13210	Recruiting
Montefiore Medical Center-Einstein Campus	The Bronx	New York	10461	Active, not recruiting
Montefiore Medical Center-Weiler Hospital	The Bronx	New York	10461	Active, not recruiting
Montefiore Medical Center - Moses Campus	The Bronx	New York	10467	Active, not recruiting
Upstate Cancer Center at Verona	Verona	New York	13478	Suspended
Wilmot Cancer Institute at Webster	Webster	New York	14580	Active, not recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Recruiting
UH Seidman Cancer Center at UH Avon Health Center	Avon	Ohio	44011	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Riverside Methodist Hospital	Columbus	Ohio	43214	Active, not recruiting
Grant Medical Center	Columbus	Ohio	43215	Active, not recruiting
Delaware Health Center-Grady Cancer Center	Delaware	Ohio	43015	Active, not recruiting
Grady Memorial Hospital	Delaware	Ohio	43015	Active, not recruiting
UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	44060	Recruiting
Mercy Health - Perrysburg Hospital	Perrysburg	Ohio	43551	Recruiting
Mercy Health - Saint Anne Hospital	Toledo	Ohio	43623	Suspended
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Saint Luke's Cancer Center - Allentown	Allentown	Pennsylvania	18104	Active, not recruiting
UPMC Altoona	Altoona	Pennsylvania	16601	Recruiting
Saint Luke's University Hospital-Bethlehem Campus	Bethlehem	Pennsylvania	18015	Active, not recruiting
Carlisle Regional Cancer Center	Carlisle	Pennsylvania	17015	Recruiting
Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	19317	Active, not recruiting
Chambersburg Hospital	Chambersburg	Pennsylvania	17201	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Saint Luke's Hospital-Anderson Campus	Easton	Pennsylvania	18045	Active, not recruiting
Ephrata Cancer Center	Ephrata	Pennsylvania	17522	Recruiting
UPMC Hillman Cancer Center Erie	Erie	Pennsylvania	16505	Recruiting
Saint Vincent Hospital	Erie	Pennsylvania	16544	Active, not recruiting
UPMC Cancer Center at UPMC Horizon	Farrell	Pennsylvania	16121	Recruiting
Adams Cancer Center	Gettysburg	Pennsylvania	17325	Recruiting
UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	15601	Recruiting
UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	17109	Recruiting
Sechler Family Cancer Center	Lebanon	Pennsylvania	17042	Recruiting
Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	17837	Recruiting
UPMC Cancer Center - Monroeville	Monroeville	Pennsylvania	15146	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Active, not recruiting
Jefferson Torresdale Hospital	Philadelphia	Pennsylvania	19114	Active, not recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Active, not recruiting
UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
UPMC-Presbyterian Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
UPMC-Saint Margaret	Pittsburgh	Pennsylvania	15215	Recruiting
UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	15232	Recruiting
UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	15237	Recruiting
UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	15243	Recruiting
Saint Luke's Hospital - Upper Bucks Campus	Quakertown	Pennsylvania	18951	Active, not recruiting
Saint Luke's Hospital-Quakertown Campus	Quakertown	Pennsylvania	18951	Suspended
Saint Luke's Hospital - Monroe Campus	Stroudsburg	Pennsylvania	18360	Active, not recruiting
Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	18711	Recruiting
Divine Providence Hospital	Williamsport	Pennsylvania	17754	Recruiting
WellSpan Health-York Cancer Center	York	Pennsylvania	17403	Recruiting
WellSpan Health-York Hospital	York	Pennsylvania	17403	Recruiting
UPMC Memorial	York	Pennsylvania	17408	Recruiting
McLeod Regional Medical Center	Florence	South Carolina	29506	Recruiting
Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	29341	Active, not recruiting
Self Regional Healthcare	Greenwood	South Carolina	29646	Active, not recruiting
Gibbs Cancer Center-Pelham	Greer	South Carolina	29651	Active, not recruiting
Spartanburg Medical Center	Spartanburg	South Carolina	29303	Active, not recruiting
SMC Center for Hematology Oncology Union	Union	South Carolina	29379	Active, not recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Active, not recruiting
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117-5134	Recruiting
MD Anderson in The Woodlands	Conroe	Texas	77384	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
MD Anderson West Houston	Houston	Texas	77079	Recruiting
MD Anderson League City	League City	Texas	77573	Recruiting
MD Anderson in Sugar Land	Sugar Land	Texas	77478	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Active, not recruiting
Langlade Hospital and Cancer Center	Antigo	Wisconsin	54409	Recruiting
ThedaCare Regional Cancer Center	Appleton	Wisconsin	54911	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Active, not recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting
Froedtert Menomonee Falls Hospital	Menomonee Falls	Wisconsin	53051	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Cancer Center of Western Wisconsin	New Richmond	Wisconsin	54017	Recruiting
Drexel Town Square Health Center	Oak Creek	Wisconsin	53154	Recruiting
Aspirus Cancer Care - James Beck Cancer Center	Rhinelander	Wisconsin	54501	Recruiting
Aspirus Cancer Care - Stevens Point	Stevens Point	Wisconsin	54481	Recruiting
Aspirus Regional Cancer Center	Wausau	Wisconsin	54401	Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center	West Bend	Wisconsin	53095	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04804644, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2026 · Synced May 6, 2026

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