ClinicalTrials.gov record
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability
ClinicalTrials.gov ID: NCT04804644
Public ClinicalTrials.gov record NCT04804644. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Trial of Stereotactic Radiosurgery (SRS) Versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases From Small Cell Lung Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.
Study identification
- NCT ID
- NCT04804644
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 152 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Magnetic Resonance Imaging Procedure
- Memantine Hydrochloride Drug
- Neurocognitive Assessment Other
- Stereotactic Radiosurgery Radiation
- Survey Administration Other
- Whole-Brain Radiotherapy Radiation
Procedure · Drug · Other + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 8, 2021 (Actual)
- Primary completion
- Jun 24, 2026 (Actual)
- Completion
- Jul 1, 2031 (Estimated)
- Last update posted
- Sep 14, 2026
2021 – 2031
United States locations
- U.S. sites
- 227
- U.S. states
- 30
- U.S. cities
- 175
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | — |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Kaiser Permanente-Ontario | Ontario | California | 91761 | — |
| UCHealth University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Memorial Hospital North | Colorado Springs | Colorado | 80920 | — |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut | 06830 | — |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | — |
| Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | — |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | 06385 | — |
| Beebe Medical Center | Lewes | Delaware | 19958 | — |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| UF Health Cancer Institute - Gainesville | Gainesville | Florida | 32610 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Moffitt Cancer Center-International Plaza | Tampa | Florida | 33607 | — |
| Moffitt Cancer Center - McKinley Campus | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center at Wesley Chapel | Wesley Chapel | Florida | 33544 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| Northside Hospital-Cherokee | Canton | Georgia | 30115 | — |
| Northside Hospital-Forsyth | Cumming | Georgia | 30041 | — |
| Memorial Health University Medical Center | Savannah | Georgia | 31404 | — |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| Rush MD Anderson Cancer Center | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| IU Health West Hospital | Avon | Indiana | 46123 | — |
| IU Health North Hospital | Carmel | Indiana | 46032 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| IU Health Methodist Hospital | Indianapolis | Indiana | 46202 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| UofL Health Medical Center Northeast | Louisville | Kentucky | 40245 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Luminis Health Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | 21237 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| Central Maryland Radiation Oncology in Howard County | Columbia | Maryland | 21044 | — |
| University of Maryland Shore Medical Center at Easton | Easton | Maryland | 21601 | — |
| UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie | Maryland | 21061 | — |
| TidalHealth Richard A Henson Cancer Institute | Ocean Pines | Maryland | 21811 | — |
| TidalHealth Peninsula Regional | Salisbury | Maryland | 21801 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Caro Cancer Center | Caro | Michigan | 48723 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Saint Mary's Oncology/Hematology Associates of Marlette | Marlette | Michigan | 48453 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| McLaren-Port Huron | Port Huron | Michigan | 48060 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | 48764 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Minnesota Oncology - Burnsville | Burnsville | Minnesota | 55337 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology - Coon Rapids | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Minnesota Oncology - Edina | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | — |
| Minnesota Oncology - Maple Grove | Maple Grove | Minnesota | 55369 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Monticello Cancer Center | Monticello | Minnesota | 55362 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| BJC Outpatient Center at Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Logan Health Medical Center | Kalispell | Montana | 59901 | — |
| Cooper Hospital University Medical Center | Camden | New Jersey | 08103 | — |
| Sands Cancer Center | Canandaigua | New York | 14424 | — |
| Northwell Health/Center for Advanced Medicine | Lake Success | New York | 11042 | — |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Upstate Cancer Center Radiation Oncology at Oswego | Oswego | New York | 13126 | — |
| Wilmot Cancer Institute Radiation Oncology at Greece | Rochester | New York | 14606 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Upstate Cancer Center at Hill Radiation Oncology | Syracuse | New York | 13210 | — |
| Montefiore Medical Center-Einstein Campus | The Bronx | New York | 10461 | — |
| Montefiore Medical Center-Weiler Hospital | The Bronx | New York | 10461 | — |
| Montefiore Medical Center - Moses Campus | The Bronx | New York | 10467 | — |
| Upstate Cancer Center at Verona | Verona | New York | 13478 | — |
| Wilmot Cancer Institute at Webster | Webster | New York | 14580 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| UH Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Riverside Methodist Hospital | Columbus | Ohio | 43214 | — |
| Grant Medical Center | Columbus | Ohio | 43215 | — |
| Delaware Health Center-Grady Cancer Center | Delaware | Ohio | 43015 | — |
| Grady Memorial Hospital | Delaware | Ohio | 43015 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| Mercy Health - Perrysburg Hospital | Perrysburg | Ohio | 43551 | — |
| Mercy Health - Saint Anne Hospital | Toledo | Ohio | 43623 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Saint Luke's Cancer Center - Allentown | Allentown | Pennsylvania | 18104 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Carlisle Regional Cancer Center | Carlisle | Pennsylvania | 17015 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Saint Luke's Hospital-Anderson Campus | Easton | Pennsylvania | 18045 | — |
| Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| Saint Vincent Hospital | Erie | Pennsylvania | 16544 | — |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | — |
| Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | — |
| Sechler Family Cancer Center | Lebanon | Pennsylvania | 17042 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| UPMC Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | 19114 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| Saint Luke's Hospital - Upper Bucks Campus | Quakertown | Pennsylvania | 18951 | — |
| Saint Luke's Hospital-Quakertown Campus | Quakertown | Pennsylvania | 18951 | — |
| Saint Luke's Hospital - Monroe Campus | Stroudsburg | Pennsylvania | 18360 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Divine Providence Hospital | Williamsport | Pennsylvania | 17754 | — |
| WellSpan Health-York Cancer Center | York | Pennsylvania | 17403 | — |
| WellSpan Health-York Hospital | York | Pennsylvania | 17403 | — |
| UPMC Memorial | York | Pennsylvania | 17408 | — |
| McLeod Regional Medical Center | Florence | South Carolina | 29506 | — |
| Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | 29341 | — |
| Self Regional Healthcare | Greenwood | South Carolina | 29646 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| SMC Center for Hematology Oncology Union | Union | South Carolina | 29379 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| MD Anderson in The Woodlands | Conroe | Texas | 77384 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| MD Anderson West Houston | Houston | Texas | 77079 | — |
| UT MD Anderson - League City | League City | Texas | 77573 | — |
| MD Anderson in Sugar Land | Sugar Land | Texas | 77478 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| ThedaCare Regional Cancer Center | Appleton | Wisconsin | 54911 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center | Madison | Wisconsin | 53718 | — |
| University of Wisconsin Carbone Cancer Center - University Hospital | Madison | Wisconsin | 53792 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| Drexel Town Square Health Center | Oak Creek | Wisconsin | 53154 | — |
| Aspirus Cancer Care - James Beck Cancer Center | Rhinelander | Wisconsin | 54501 | — |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | 53095 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04804644, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 14, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04804644 live on ClinicalTrials.gov.