Novel mGluR5 Modulator Effects on Alcohol Drinking and MRI Outcomes

ClinicalTrials.gov ID: NCT04831684

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Official title

Effects of a Novel mGluR5 Negative Allosteric Modulator on Alcohol Drinking, Neurochemistry, and Brain Reactivity to Alcohol Cues in Alcohol Use Disorder

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study evaluates the effects of the medication GET73 among non-treatment-seeking individuals who regularly drink alcohol. Participants in the study will take GET73 or placebo for an 8-day study. There are 4 study visits including 2 MRI scans.

Study identification

NCT ID: NCT04831684
Recruitment status: Completed
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Medical University of South Carolina; Other
Enrollment: 79 participants

Conditions and interventions

Conditions

Alcohol Use Disorder

Interventions

Placebo Drug
GET73 Drug

Drug

Eligibility (public fields only)

Age range: 21 Years to 40 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 15, 2021 (Actual)
Primary completion: Dec 29, 2025 (Actual)
Completion: Dec 29, 2025 (Actual)
Last update posted: Feb 5, 2026

2021 – 2025

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Charleston Alcohol Research Center, Institute of Psychiatry, Medical University of South Carolina	Charleston	South Carolina	29425	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04831684, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 5, 2026 · Synced Nov 14, 2026