Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

ClinicalTrials.gov ID: NCT04840602

Public ClinicalTrials.gov record NCT04840602. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 1:34 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

Study identification

NCT ID: NCT04840602
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 92 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Bone Marrow Aspiration Procedure
Bone Marrow Biopsy Procedure
Computed Tomography Procedure
Ibrutinib Drug
Positron Emission Tomography Procedure
Rituximab Biological
Venetoclax Drug
Zanubrutinib Drug

Procedure · Drug · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 4, 2022
Primary completion: Mar 30, 2028
Completion: Mar 30, 2028
Last update posted: Apr 12, 2026

2022 – 2028

United States locations

U.S. sites: 125
U.S. states: 16
U.S. cities: 94

Facility	City	State	ZIP	Site status
Banner University Medical Center - Tucson	Tucson	Arizona	85719	Recruiting
University of Arizona Cancer Center-North Campus	Tucson	Arizona	85719	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs	Coral Springs	Florida	33065	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
UM Sylvester Comprehensive Cancer Center at Doral	Doral	Florida	33166	Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood	Hollywood	Florida	33021	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224-9980	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	33176	Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia	North Miami	Florida	33181	Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Suspended
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Recruiting
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Suspended
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor	Michigan	48106	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health Medical Center - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health Medical Center - Canton	Canton	Michigan	48188	Recruiting
Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	48346	Recruiting
Newland Medical Associates-Clarkston	Clarkston	Michigan	48346	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Cancer Hematology Centers - Flint	Flint	Michigan	48503	Recruiting
Genesee Hematology Oncology PC	Flint	Michigan	48503	Suspended
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Hurley Medical Center	Flint	Michigan	48503	Recruiting
University of Michigan Health - Sparrow Lansing	Lansing	Michigan	48912	Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Michigan Healthcare Professionals Pontiac	Pontiac	Michigan	48341	Recruiting
Newland Medical Associates-Pontiac	Pontiac	Michigan	48341	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
MyMichigan Medical Center Saginaw	Saginaw	Michigan	48601	Recruiting
Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	48604	Suspended
MyMichigan Medical Center Tawas	Tawas City	Michigan	48764	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Huron Gastroenterology PC	Ypsilanti	Michigan	48106	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Active, not recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Active, not recruiting
Heartland Regional Medical Center	Saint Joseph	Missouri	64506	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Active, not recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Active, not recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Active, not recruiting
Saint Vincent Frontier Cancer Center	Billings	Montana	59102	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Glens Falls Hospital	Glens Falls	New York	12801	Active, not recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	10032	Active, not recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	28328	Recruiting
Levine Cancer Institute-Gaston	Gastonia	North Carolina	28054	Recruiting
Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	27534	Recruiting
Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	28546	Recruiting
Strecker Cancer Center-Belpre	Belpre	Ohio	45714	Suspended
Adena Regional Medical Center	Chillicothe	Ohio	45601	Suspended
Mount Carmel East Hospital	Columbus	Ohio	43213	Suspended
Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	43214	Suspended
Riverside Methodist Hospital	Columbus	Ohio	43214	Suspended
Grant Medical Center	Columbus	Ohio	43215	Suspended
The Mark H Zangmeister Center	Columbus	Ohio	43219	Suspended
Mount Carmel Health Center West	Columbus	Ohio	43222	Suspended
Doctors Hospital	Columbus	Ohio	43228	Suspended
Delaware Health Center-Grady Cancer Center	Delaware	Ohio	43015	Suspended
Grady Memorial Hospital	Delaware	Ohio	43015	Suspended
Dublin Methodist Hospital	Dublin	Ohio	43016	Suspended
Central Ohio Breast and Endocrine Surgery	Gahanna	Ohio	43230	Suspended
Mount Carmel Grove City Hospital	Grove City	Ohio	43123	Suspended
Fairfield Medical Center	Lancaster	Ohio	43130	Suspended
Saint Rita's Medical Center	Lima	Ohio	45801	Suspended
OhioHealth Mansfield Hospital	Mansfield	Ohio	44903	Suspended
Marietta Memorial Hospital	Marietta	Ohio	45750	Suspended
OhioHealth Marion General Hospital	Marion	Ohio	43302	Suspended
Knox Community Hospital	Mount Vernon	Ohio	43050	Suspended
Licking Memorial Hospital	Newark	Ohio	43055	Recruiting
Newark Radiation Oncology	Newark	Ohio	43055	Suspended
Mercy Health - Perrysburg Hospital	Perrysburg	Ohio	43551	Suspended
Southern Ohio Medical Center	Portsmouth	Ohio	45662	Suspended
Mercy Health - Saint Vincent Hospital	Toledo	Ohio	43608	Suspended
Mercy Health - Saint Anne Hospital	Toledo	Ohio	43623	Suspended
Saint Ann's Hospital	Westerville	Ohio	43081	Suspended
Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	43701	Suspended
Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	97015	Suspended
Providence Newberg Medical Center	Newberg	Oregon	97132	Recruiting
Providence Willamette Falls Medical Center	Oregon City	Oregon	97045	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Swedish Cancer Institute-Edmonds	Edmonds	Washington	98026	Recruiting
Swedish Cancer Institute-Issaquah	Issaquah	Washington	98029	Recruiting
Swedish Medical Center-First Hill	Seattle	Washington	98122	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Active, not recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Active, not recruiting
Marshfield Medical Center - Minocqua	Minocqua	Wisconsin	54548	Active, not recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Active, not recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Active, not recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04840602, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced May 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04840602 live on ClinicalTrials.gov.

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