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Recruiting Phase 2 Interventional

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

ClinicalTrials.gov ID: NCT04840602

Public ClinicalTrials.gov record NCT04840602. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 1:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Randomized Study Comparing BTK Inhibitors (Ibrutinib Plus Rituximab or Zanubrutinib Alone) vs. BCL-2 Inhibitor (Venetoclax) and Rituximab in Previously Untreated Waldenström's Macroglobulinemia (WM) / Lymphoplasmacytic Lymphoma (LPL)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib, a type of tyrosine kinase inhibitor, blocks a protein called BTK, which may help keep cancer cells from growing. Giving venetoclax and rituximab may work better in treating patients with previously untreated Waldenstrom's macroglobulinemia than ibrutinib with rituximab or zanubrutinib alone.

Study identification

NCT ID
NCT04840602
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
92 participants

Conditions and interventions

Interventions

Procedure · Drug · Biological

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jan 4, 2022
Primary completion
Mar 30, 2028
Completion
Mar 30, 2028
Last update posted
Jul 28, 2026

2022 – 2028

United States locations

U.S. sites
138
U.S. states
18
U.S. cities
104
Facility City State ZIP Site status
Banner University Medical Center - Tucson Tucson Arizona 85719 Recruiting
University of Arizona Cancer Center-North Campus Tucson Arizona 85719 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs Florida 33065 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida 33021 Recruiting
Mayo Clinic in Florida Jacksonville Florida 32224-9980 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia North Miami Florida 33181 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 Recruiting
Centralia Oncology Clinic Centralia Illinois 62801 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Loyola University Medical Center Maywood Illinois 60153 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
McFarland Clinic - Boone Boone Iowa 50036 Suspended
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Recruiting
McFarland Clinic - Jefferson Jefferson Iowa 50129 Suspended
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health Medical Center - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health Medical Center - Canton Canton Michigan 48188 Recruiting
Chelsea Hospital Chelsea Michigan 48118 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
Hematology Oncology Consultants-Clarkston Clarkston Michigan 48346 Recruiting
Newland Medical Associates-Clarkston Clarkston Michigan 48346 Suspended
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 Recruiting
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 Recruiting
Cancer Hematology Centers - Flint Flint Michigan 48503 Recruiting
Genesee Hematology Oncology PC Flint Michigan 48503 Suspended
Genesys Hurley Cancer Institute Flint Michigan 48503 Recruiting
Hurley Medical Center Flint Michigan 48503 Recruiting
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Henry Ford Medical Center-Columbus Novi Michigan 48377 Recruiting
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341 Recruiting
Newland Medical Associates-Pontiac Pontiac Michigan 48341 Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Recruiting
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 Recruiting
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604 Suspended
MyMichigan Medical Center Tawas Tawas City Michigan 48764 Recruiting
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Recruiting
Huron Gastroenterology PC Ypsilanti Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Hennepin County Medical Center Minneapolis Minnesota 55415 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Active, not recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Active, not recruiting
Heartland Regional Medical Center Saint Joseph Missouri 64506 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Active, not recruiting
Mercy Hospital South St Louis Missouri 63128 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Active, not recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Active, not recruiting
Saint Vincent Frontier Cancer Center Billings Montana 59102 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Glens Falls Hospital Glens Falls New York 12801 Active, not recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 Active, not recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
University of Rochester Rochester New York 14642 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 Recruiting
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 Recruiting
Levine Cancer Institute-Gaston Gastonia North Carolina 28054 Recruiting
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 Recruiting
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 Recruiting
Atrium Health Union/LCI-Union Monroe North Carolina 28112 Recruiting
Strecker Cancer Center-Belpre Belpre Ohio 45714 Suspended
Adena Regional Medical Center Chillicothe Ohio 45601 Suspended
Mount Carmel East Hospital Columbus Ohio 43213 Suspended
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214 Suspended
Riverside Methodist Hospital Columbus Ohio 43214 Suspended
Grant Medical Center Columbus Ohio 43215 Suspended
The Mark H Zangmeister Center Columbus Ohio 43219 Suspended
Mount Carmel Health Center West Columbus Ohio 43222 Suspended
Doctors Hospital Columbus Ohio 43228 Suspended
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 Suspended
Grady Memorial Hospital Delaware Ohio 43015 Suspended
Dublin Methodist Hospital Dublin Ohio 43016 Suspended
Central Ohio Breast and Endocrine Surgery Gahanna Ohio 43230 Suspended
Mount Carmel Grove City Hospital Grove City Ohio 43123 Suspended
Fairfield Medical Center Lancaster Ohio 43130 Suspended
Saint Rita's Medical Center Lima Ohio 45801 Suspended
OhioHealth Mansfield Hospital Mansfield Ohio 44903 Suspended
Marietta Memorial Hospital Marietta Ohio 45750 Suspended
OhioHealth Marion General Hospital Marion Ohio 43302 Suspended
Knox Community Hospital Mount Vernon Ohio 43050 Suspended
Licking Memorial Hospital Newark Ohio 43055 Recruiting
Newark Radiation Oncology Newark Ohio 43055 Suspended
Mercy Health - Perrysburg Hospital Perrysburg Ohio 43551 Suspended
Southern Ohio Medical Center Portsmouth Ohio 45662 Suspended
Mercy Health - Saint Vincent Hospital Toledo Ohio 43608 Suspended
Mercy Health - Saint Anne Hospital Toledo Ohio 43623 Suspended
Saint Ann's Hospital Westerville Ohio 43081 Suspended
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701 Suspended
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015 Suspended
Providence Newberg Medical Center Newberg Oregon 97132 Recruiting
Providence Willamette Falls Medical Center Oregon City Oregon 97045 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 Recruiting
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 Recruiting
Swedish Medical Center-First Hill Seattle Washington 98122 Recruiting
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 Recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 Active, not recruiting
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 Recruiting
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 Active, not recruiting
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 Active, not recruiting
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 Active, not recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04840602, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 28, 2026 · Synced Sep 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04840602 live on ClinicalTrials.gov.

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