ClinicalTrials.gov record
Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM
ClinicalTrials.gov ID: NCT04848506
Public ClinicalTrials.gov record NCT04848506. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Follow-Up, Open-Label, Research Evaluation of Sustained Treatment With Aficamten (CK-3773274) in Hypertrophic Cardiomyopathy (HCM)
Study identification
- NCT ID
- NCT04848506
- Recruitment status
- Enrolling by invitation
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Cytokinetics
- Industry
- Enrollment
- 900 participants
Conditions and interventions
Interventions
- Aficamten (5 - 20 mg) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 5, 2021
- Primary completion
- Feb 29, 2028
- Completion
- Feb 29, 2028
- Last update posted
- Jan 21, 2026
2021 – 2028
United States locations
- U.S. sites
- 52
- U.S. states
- 28
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Alaska Heart and Vascular Institute | Anchorage | Alaska | 99508 | — |
| Mayo Clinic Building - Phoenix | Phoenix | Arizona | 85054 | — |
| UC San Diego Health - Sulpizio Cardiovascular Center | La Jolla | California | 92037 | — |
| Cedar-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Cedars-Sinai Medical Center (Smidt Heart Institute) | Los Angeles | California | 90048 | — |
| UCSF Medical Center | San Francisco | California | 94143 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06519 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Holy Cross Hospital / Cardiology Associates | Fort Lauderdale | Florida | 33308 | — |
| Emory Clinic | Atlanta | Georgia | 30322 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| Michigan Medicine - University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Michigan Health System (UMHS) - University Hospital (University of Michigan Medical Center) | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Northwell Health North Shore University Hospital | Manhasset | New York | 11030 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Weill Cornell Medicine | New York | New York | 10021 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center/New York Presbyterian Hospital | New York | New York | 10032 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Sanger Heart & Vascular Institute - HCM Clinic | Charlotte | North Carolina | 28204 | — |
| Duke Cardiology at Southpoint | Durham | North Carolina | 27710 | — |
| The Linder Research Center at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ascension St. John Clinical Research Institute | Tulsa | Oklahoma | 76104 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine) | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Greenville Memorial Hospital | Greenville | South Carolina | 29605 | — |
| Ascension Saint Thomas Heart West | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| The University of Texas Southwestern Medical Center at Dallas | Dallas | Texas | 75390 | — |
| CHI St. Luke's Health Baylor College of Medicine Medical Center | Houston | Texas | 77030 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Health | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health System University Hospital | Charlottesville | Virginia | 22908 | — |
| Inova Health Care Services | Falls Church | Virginia | 22042 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| WVUMedicine | Morgantown | West Virginia | 26506 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 77 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04848506, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2026 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04848506 live on ClinicalTrials.gov.