A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)
Public ClinicalTrials.gov record NCT04865770. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Renal Mode of Action of Semaglutide in Patients With Type 2 Diabetes and Chronic Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
We are doing this study to learn more about how semaglutide may help fight chronic kidney disease in people with type 2 diabetes. We are doing this by looking into how semaglutide works in the kidneys. Participants will either get semaglutide or placebo (a 'dummy' medicine) - which treatment participants get is decided by chance. Semaglutide is a medicine doctors can prescribe in some countries for the treatment of type 2 diabetes. Participants will get the study medicine in a pen. Participants will use the pen to inject the medicine into the skin once a week. The study will last for about 1 year. Participants will have 11 visits to the clinic, and 2 phone visits. Some of the visits could be in different locations. Study staff will take blood samples at most of these visits. At 9 visits, participants will be asked to bring a sample of their first morning urine. At 4 of the visits participants will have to bring urine that they have collected over the last 24 hours. The study includes magnetic resonance imaging (MRI) scans of participants' kidneys which is a test that shows a detailed picture of organs and other parts inside the body. The scan will last for 30 minutes, and is free of radiation.
Study identification
- NCT ID
- NCT04865770
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 106 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 28, 2021 (Actual)
- Primary completion
- Nov 21, 2024 (Actual)
- Completion
- Nov 21, 2024 (Actual)
- Last update posted
- Feb 10, 2026
2021 – 2024
United States locations
- U.S. sites
- 20
- U.S. states
- 12
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona-CaTs | Tucson | Arizona | 85724 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Roderick A. Comunale II MD Inc. | National City | California | 91950 | — |
| N America Res Inst - San Dimas | San Dimas | California | 91773 | — |
| UC Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Advent Health-Res Inst | Orlando | Florida | 32804 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Emory University Hsptl - Atlanta | Atlanta | Georgia | 30322 | — |
| Endeavor Health Glenbook Hosp | Evanston | Illinois | 60201 | — |
| North Suburban Nephrology LLC | Gurnee | Illinois | 60031 | — |
| University of Minnesota Health Clinical | Minneapolis | Minnesota | 55455 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| Cleveland Clinic_Cleveland | Cleveland | Ohio | 44195 | — |
| Prolato Clinical Research Cntr | Houston | Texas | 77054 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| University of Texas San Antonio | San Antonio | Texas | 78284 | — |
| Univ of Washington Med Ctr | Seattle | Washington | 98195 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| Medical College Of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 29 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04865770, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 10, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04865770 live on ClinicalTrials.gov.