ClinicalTrials.gov record
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
ClinicalTrials.gov ID: NCT04879329
Public ClinicalTrials.gov record NCT04879329. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 5:38 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Multi-Cohort, Open-Label, Multi-Center Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin (RC48-ADC) Alone or in Combination With Pembrolizumab in Subjects With Locally-Advanced Unresectable or Metastatic Urothelial Carcinoma That Expresses HER2
Study identification
- NCT ID
- NCT04879329
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Industry
- Enrollment
- 372 participants
Conditions and interventions
Conditions
Interventions
- disitamab vedotin Drug
- pembrolizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2, 2022
- Primary completion
- Dec 10, 2026
- Completion
- Apr 13, 2029
- Last update posted
- Apr 20, 2026
2022 – 2029
United States locations
- U.S. sites
- 159
- U.S. states
- 18
- U.S. cities
- 99
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Gateway Medical Center | Gilbert | Arizona | 85234 | Recruiting |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| Kaiser Permanente Anaheim Kraemer Medical Offices | Anaheim | California | 92806 | Recruiting |
| Foothill Cardioology | Arcadia | California | 91007 | Recruiting |
| Kaiser Permanente Baldwin Park Medical Center | Baldwin Park | California | 91706 | Recruiting |
| Kaiser Permanente Bellflower Medical Offices | Bellflower | California | 90706 | Recruiting |
| Beverly Hills Multi-Specialties Practice | Beverly Hills | California | 90211 | Recruiting |
| Providence Saint Joseph Medical Center | Burbank | California | 91505 | Recruiting |
| UCLA Burbank Cardiology | Burbank | California | 91505 | Recruiting |
| UCLA Hematology/Oncology - Burbank | Burbank | California | 91505 | Recruiting |
| City of Hope (City of Hope National Medical Center, City of Hope Medical Center) | Duarte | California | 91010 | Active, not recruiting |
| UCLA Encino Specialty Care (Radiology) | Encino | California | 91436 | Recruiting |
| UCLA Hematology/Oncoclogy-Encino | Encino | California | 91436 | Recruiting |
| Kaiser Permanente Fontana Medical Center | Fontana | California | 92335 | Recruiting |
| Foothill Cardiology Glendora | Glendora | California | 91741 | Recruiting |
| Kaiser Permanente South Bay Medical center | Harbor City | California | 90710 | Recruiting |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | Recruiting |
| Kaiser Permanente Alton/Sand Canyon Medical Offices | Irvine | California | 92618 | Recruiting |
| UCLA Downtown Los Angeles Primary & Specialty Care | Los Angeles | California | 90017 | Recruiting |
| Kaiser Permanente Los Angeles Medical Offices | Los Angeles | California | 90027 | Recruiting |
| Kaiser Permanente West Los Angeles Medical Center | Los Angeles | California | 90034 | Recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Not yet recruiting |
| Ronald Reagan UCLA Medical Center, Drug Information Center | Los Angeles | California | 90095 | Recruiting |
| UCLA Cardiovascular Center | Los Angeles | California | 90095 | Recruiting |
| UCLA Hematology Oncology | Los Angeles | California | 90095 | Recruiting |
| UCLA Westwood Specialty Care | Los Angeles | California | 90095 | Recruiting |
| UCLA Santa Monica Cardiology | Los Angeles | California | 90404 | Recruiting |
| UCLA Montecito Primary & Specialty Care | Montecito | California | 93108 | Recruiting |
| Newport Diagnostics Center (Radiology) | Newport Beach | California | 92660 | Recruiting |
| Kaiser Permanente Ontario Medical Center | Ontario | California | 91761 | Recruiting |
| UC Irvine Health | Orange | California | 92868 | Recruiting |
| Kaiser Permanente Panorama City Medical Center, Medical Offices 3 | Panorama City | California | 91402 | Recruiting |
| Foothill Cardiology Pasadena | Pasadena | California | 91105 | Recruiting |
| Southern California Heart Specialists | Pasadena | California | 91105 | Recruiting |
| UCLA Hematology/ Oncology- Pasadena | Pasadena | California | 91105 | Recruiting |
| UCLA Hematology Oncology - Porter Ranch | Porter Ranch | California | 91326 | Recruiting |
| UCLA Porter Ranch Primary & Specialty Care | Porter Ranch | California | 91326 | Recruiting |
| Kaiser Permanente Riverside Medical Center | Riverside | California | 92505 | Recruiting |
| Southern California Permanente Medical Group (SCPMG) | Riverside | California | 92505 | Recruiting |
| Kaiser Permanente San Diego Mission Road (Regulatory and Lab Supplies) | San Diego | California | 92108 | Recruiting |
| Kaiser Permanente Zion Medical Center | San Diego | California | 92120 | Recruiting |
| UCSF Cancer Center MZ Phlebotomy | San Francisco | California | 94115 | Recruiting |
| UCSF Mount Zion Phlebotomy | San Francisco | California | 94115 | Recruiting |
| UCSF Parnassus Phlebotomy | San Francisco | California | 94143 | Recruiting |
| UCSF Investigational Drugs Pharmacy | San Francisco | California | 94158 | Recruiting |
| University of California, San Francisco | HDFCCC - Hematopoietic Malignancies | San Francisco | California | 94158 | Recruiting |
| University of California, San Francisco | San Francisco | California | 94158 | Recruiting |
| Diagnostic Medical Group of Southern California (Radiology) | San Gabriel | California | 91776 | Recruiting |
| Southern California Heart Centers | San Gabriel | California | 91776 | Recruiting |
| UCLA Hematology/Oncology - San Luis Obispo | San Luis Obispo | California | 93401 | Recruiting |
| Sierra Vista Regional Medical Center | San Luis Obispo | California | 93405 | Recruiting |
| Kaiser Permanente San Marcos Medical Offices | San Marcos | California | 92078 | Recruiting |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | Recruiting |
| UCLA Simi Valley Alamo Specialty Care | Simi Valley | California | 93065 | Recruiting |
| Twin Cities Community Hospital | Templeton | California | 93465 | Recruiting |
| UCLA Thousand Oaks Primary & Specialty Care | Thousand Oaks | California | 91360 | Recruiting |
| UCLA Hematology/Oncology - Torrance | Torrance | California | 90505 | Recruiting |
| UCLA Torrance Lomita Specialty Care | Torrance | California | 90505 | Recruiting |
| UCLA Hematology-Oncology Clinic - Santa Clarita | Valencia | California | 91355 | Recruiting |
| UCLA Santa Clarita Primary & Specialty Care | Valencia | California | 91355 | Recruiting |
| UCLA Hematology/Oncology - Ventura | Ventura | California | 93003 | Recruiting |
| UCLA Ventura Cardiology | Ventura | California | 93003 | Recruiting |
| UCLA Hematology/Oncology - Westlake | Westlake Village | California | 91361 | Recruiting |
| Kaiser Permanente Woodland Hills Medical Center | Woodland Hills | California | 91367 | Recruiting |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | Not yet recruiting |
| Florida Cancer Specialists | Bonita Springs | Florida | 34135 | Recruiting |
| Florida Cancer Specialists | Bradenton | Florida | 34205 | Recruiting |
| Florida Cancer Specialists | Bradenton | Florida | 34211 | Recruiting |
| Florida Cancer Specialists | Cape Coral | Florida | 33909 | Recruiting |
| Florida Cancer Specialists | Daytona Beach | Florida | 32117 | Active, not recruiting |
| Florida Cancer Specialists | Fleming Island | Florida | 32003 | Recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | Recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | Recruiting |
| Florida Cancer Specialists | N. Venice | Florida | 34275 | Recruiting |
| Florida Cancer Specialists | Naples | Florida | 34102 | Recruiting |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | Recruiting |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | Recruiting |
| Florida Cancer Specialists Sarasota Memorial Hospital (SAD) | Sarasota | Florida | 34239 | Recruiting |
| Florida Cancer Specialists | Stuart | Florida | 34994 | Active, not recruiting |
| Florida Cancer Specialists | Tallahassee | Florida | 32308 | Recruiting |
| Moffitt Cancer Center McKinley Hospital | Tampa | Florida | 33612 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Florida Cancer Specialists | Venice | Florida | 34285 | Recruiting |
| Florida Cancer Specialists | Venice | Florida | 34292 | Recruiting |
| Florida Cancer Specialists | Vero Beach | Florida | 32960 | Active, not recruiting |
| Florida Cancer Specialists | Wellington | Florida | 33414 | Active, not recruiting |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | Active, not recruiting |
| Northwest Georgia Oncology Centers, a Service of Tanner Medical Center Villa Rica | Carrollton | Georgia | 30117 | Active, not recruiting |
| West Georgia Infusion Center, a Service of Tanner Medical Center Villa Rica | Carrollton | Georgia | 30117 | Active, not recruiting |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Cartersville | Georgia | 30121 | Active, not recruiting |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Douglasville | Georgia | 30134 | Active, not recruiting |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Hiram | Georgia | 30141 | Active, not recruiting |
| WellStar Paulding Hospital | Hiram | Georgia | 30141 | Active, not recruiting |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Marietta | Georgia | 30060 | Active, not recruiting |
| UChicago Medicine - River East | Chicago | Illinois | 60611 | Recruiting |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | Recruiting |
| Accellacare - Deerfield | Deerfield | Illinois | 60015 | Recruiting |
| UChicago Medicine at Ingalls - Flossmoor | Flossmoor | Illinois | 60422 | Recruiting |
| UChicago Medicine Ingalls Memorial | Harvey | Illinois | 60426 | Recruiting |
| University of Chicago Comprehensive Cancer Center at Silver Cross Hospital | New Lenox | Illinois | 60451 | Recruiting |
| The University of Chicago Medicine Center for Advanced Care Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| UChicago Medicine at Ingalls - Tinley Park | Tinley Park | Illinois | 60477 | Recruiting |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01655 | Recruiting |
| University of Massachusetts Chan Medical School | Worcester | Massachusetts | 01655 | Recruiting |
| The Cancer & Hematology Centers | Big Rapids | Michigan | 49307 | Recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion) | Detroit | Michigan | 48202 | Recruiting |
| Karmanos Cancer Institute Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | Recruiting |
| The Cancer & Hematology Centers | Grand Rapids | Michigan | 49503 | Recruiting |
| Cancer & Hematology Centers of Western Michigan, PC- Kit Storage | Grand Rapids | Michigan | 49546 | Recruiting |
| The Cancer & Hematology Centers | Grand Rapids | Michigan | 49546 | Recruiting |
| The Cancer & Hematology Centers | Holland | Michigan | 49424 | Recruiting |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | Recruiting |
| The Cancer & Hematology Centers | Norton Shores | Michigan | 49444 | Recruiting |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| MSK Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| MSK Bergen | Montvale | New Jersey | 07645 | Recruiting |
| MSK Commack | Commack | New York | 11725 | Recruiting |
| MSK Wesrchester | Harrison | New York | 10604 | Recruiting |
| Northwell Health | Lake Success | New York | 11042 | Active, not recruiting |
| Memorial Sloan Kattering Cancer Centre- Investigational Drug Service Pharmacy | Long Island City | New York | 11101 | Recruiting |
| Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street). | New York | New York | 10021 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Evelyn H. Lauder Breast and Imaging Centre (BAIC) | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Cancer Center - Main Campus | New York | New York | 10065 | Recruiting |
| Sidney Kimmel Center for Prostate and Urological Cancers - Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | Active, not recruiting |
| MSK nassau | Uniondale | New York | 11553 | Recruiting |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| UNC Lineberger Comprehensive Cancer Center / University of North Carolina | Chapel Hill | North Carolina | 27599 | Not yet recruiting |
| Carolinas Medical Center (biopsy only) | Charlotte | North Carolina | 28203 | Recruiting |
| Carolinas Medical Center Investigational Drug Services | Charlotte | North Carolina | 28204 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Recruiting |
| Atrium Health Mercy (biopsy only) | Charlotte | North Carolina | 28207 | Recruiting |
| Atrium Health University City (biopsy only) | Charlotte | North Carolina | 28262 | Recruiting |
| Levine Cancer Institute University | Charlotte | North Carolina | 28262 | Recruiting |
| Levine Cancer Institute - Ballantyne | Charlotte | North Carolina | 28277 | Recruiting |
| Atrium Health Cabarrus (biopsy only) | Concord | North Carolina | 28025 | Recruiting |
| Levine Cancer Institute Concord | Concord | North Carolina | 28025 | Recruiting |
| Levine Cancer Institute- Gaston | Gastonia | North Carolina | 28054 | Recruiting |
| Atrium Health Union (biopsy only) | Monroe | North Carolina | 28112 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Ohio State University Hospital | Columbus | Ohio | 43210 | Recruiting |
| Ohio State University | Columbus | Ohio | 43210 | Recruiting |
| OSU Wexner Medical Center & James Cancer Hospital | Columbus | Ohio | 43210 | Recruiting |
| OSU Wexner Medical Center, Investigational Drug Services | Columbus | Ohio | 43210 | Recruiting |
| The James Cancer Hospital & Solove Research Institute at The OSU Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| The James Outpatient Care West Campus | Columbus | Ohio | 43221 | Recruiting |
| OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| OU Medical Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | Recruiting |
| Baylor Scott and White Research Institute | Dallas | Texas | 75204 | Not yet recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Baylor Scott & White Medical Center - Temple | Temple | Texas | 76508 | Not yet recruiting |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | Recruiting |
| Harborview Medical Center | Seattle | Washington | 98104 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington Medical Center | Seattle | Washington | 98195 | Recruiting |
| Froedtert Hospital/Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04879329, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04879329 live on ClinicalTrials.gov.