PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

ClinicalTrials.gov ID: NCT04889872

Public ClinicalTrials.gov record NCT04889872. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

The PROGRESS Trial: A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement

Study identification

NCT ID: NCT04889872
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Edwards Lifesciences; Industry
Enrollment: 2,250 participants

Conditions and interventions

Conditions

Interventions

SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Device

Device

Eligibility (public fields only)

Age range: 65 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 11, 2021
Primary completion: May 31, 2029
Completion: May 31, 2037
Last update posted: Dec 16, 2025

2021 – 2037

United States locations

U.S. sites: 65
U.S. states: 27
U.S. cities: 55

Facility	City	State	ZIP	Site status
Heart Center LLC, Huntsville	Huntsville	Alabama	35801	Recruiting
Tucson Medical Center	Tucson	Arizona	85712	Active, not recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Huntington Hospital	Pasadena	California	91105	Withdrawn
Eisenhower Desert Cardiology Center	Rancho Mirage	California	92270	Recruiting
Bay Area Structural Heart at Sutter Health	San Francisco	California	94109	Recruiting
Kaiser San Francisco Medical Center	San Francisco	California	94118	Active, not recruiting
University of California San Francisco	San Francisco	California	94143	Recruiting
Santa Barbara Cottage Hospital	Santa Barbara	California	93105	Recruiting
Stanford Univeristy	Stanford	California	94305	Recruiting
UC Health Medical Center of the Rockies	Loveland	Colorado	80538	Recruiting
Yale Universtiy	New Haven	Connecticut	06510	Recruiting
The Cardiac & Vascular Institute Research Foundation	Gainesville	Florida	32605	Withdrawn
Baptist Health Research Center	Jacksonville	Florida	32207	Recruiting
Sarasota Memorial Health Care System	Sarasota	Florida	34239	Recruiting
Emory University Atlanta	Atlanta	Georgia	30308	Recruiting
Piedmont Heart Institute	Atlanta	Georgia	30309	Recruiting
Saint Alphonsus	Boise	Idaho	83704	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Alexian Brothers Hospital	Lisle	Illinois	60532	Recruiting
Ascension Via Christi St. Francis	Wichita	Kansas	67226	Recruiting
Louisiana State University	New Orleans	Louisiana	70112	Recruiting
Ochsner Clinical Foundation	New Orleans	Louisiana	70121	Active, not recruiting
Massachusetts General Hospital Boston	Boston	Massachusetts	02114	Recruiting
Minneapolis Heart Institue, St. Paul's	Minneapolis	Minnesota	55102	Recruiting
CentraCare Heart and Vascular Center	Saint Cloud	Minnesota	56303	Recruiting
Saint Luke's Hospital of Kansas City Mid America	Kansas City	Missouri	64111	Recruiting
St. Patrick Hospital	Missoula	Montana	59802	Active, not recruiting
Mary Hitchcock Memorial Hospital	Lebanon	New Hampshire	03756	Recruiting
Atlantic Health System Hospital Corp - Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Rutgers Robert Wood Johnson Medical School	New Brunswick	New Jersey	08901	Recruiting
The Valley Hospital	Ridgewood	New Jersey	07450	Recruiting
University of Buffalo Kaleida Health	Buffalo	New York	14203	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
NYU Langone Health	New York	New York	10016	Withdrawn
Columbia University Irving Medical Center/NYPH	New York	New York	10032	Active, not recruiting
Rochester General Hospital	Rochester	New York	14621	Recruiting
St. Francis Hospital	Roslyn	New York	11576	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Moses Cone Memorial Hospital	Greensboro	North Carolina	27401	Recruiting
The Christ Hospital	Cincinnati	Ohio	45219	Active, not recruiting
Mount Carmel Health System	Columbus	Ohio	43213	Active, not recruiting
Oklahoma Heart Institute	Tulsa	Oklahoma	74104	Recruiting
Kaiser Permanente Northwest	Clackamas	Oregon	97015	Active, not recruiting
Providence Heart & Vascular Institute Portland	Portland	Oregon	97225	Withdrawn
Legacy Emanuel Medical Center	Portland	Oregon	97227	Recruiting
Allegheny Singer Research Institute	Pittsburgh	Pennsylvania	15212	Recruiting
UPMC Presbyterian Shadyside	Pittsburgh	Pennsylvania	15213	Active, not recruiting
Pinnacle Health Harrisburg	Wormleysburg	Pennsylvania	17043	Active, not recruiting
Lankenau Medical Center	Wynnewood	Pennsylvania	19096	Recruiting
Baptist Memorial Hospital Memphis	Germantown	Tennessee	38138	Recruiting
Methodist Le Bonheur Healthcare	Germantown	Tennessee	38138	Recruiting
Parkwest Medical Center	Knoxville	Tennessee	37923	Recruiting
Saint Thomas Health	Nashville	Tennessee	37205	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Ascension Texas Cardiovascular	Austin	Texas	78705	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75235	Recruiting
HCA Houston Healthcare Medical Center	Houston	Texas	77004	Recruiting
The University of Texas Health Science Center	Houston	Texas	77030	Recruiting
The Heart Hospital Baylor Plano	Plano	Texas	75093	Recruiting
Methodist Hospital of San Antonio	San Antonio	Texas	78229	Active, not recruiting
Kaiser Mid Atlantic	McLean	Virginia	22102	Recruiting
Sentara Norfolk General Hospital	Norfolk	Virginia	23507	Recruiting
Swedish Medical Center	Seattle	Washington	98112	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04889872, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 16, 2025 · Synced Apr 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04889872 live on ClinicalTrials.gov.

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