A Study Evaluating the Efficacy and Safety of Afimetoran Compared With Placebo in Participants With Active Systemic Lupus Erythematosus (SLE)
Public ClinicalTrials.gov record NCT04895696. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Afimetoran in Participants With Active Systemic Lupus Erythematosus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the effectiveness, safety and tolerability of Afimetoran in participants with active Systemic Lupus Erythematosus (SLE). The extension period will provide additional long-term safety and efficacy data and enable those participants initially randomized to placebo to receive treatment with Afimetoran.
Study identification
- NCT ID
- NCT04895696
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 248 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 11, 2021 (Actual)
- Primary completion
- Jun 12, 2026 (Actual)
- Completion
- Apr 22, 2029 (Estimated)
- Last update posted
- Aug 17, 2026
2021 – 2029
United States locations
- U.S. sites
- 36
- U.S. states
- 17
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0100 | Birmingham | Alabama | 35205 | — |
| Local Institution - 0123 | Huntington Beach | California | 92648 | — |
| Local Institution - 0170 | La Jolla | California | 92037 | — |
| Local Institution - 0159 | La Palma | California | 90623 | — |
| Local Institution - 0172 | San Diego | California | 92128 | — |
| Local Institution - 0164 | Woodland Hills | California | 91364 | — |
| Local Institution - 0121 | Clearwater | Florida | 33765 | — |
| Local Institution - 0167 | Kissimmee | Florida | 34741 | — |
| Local Institution - 0122 | Orlando | Florida | 32808 | — |
| Local Institution - 0173 | Ormond Beach | Florida | 32174 | — |
| Local Institution - 0154 | Plantation | Florida | 33324 | — |
| Local Institution - 0137 | South Miami | Florida | 33143 | — |
| Local Institution - 0155 | Tamarac | Florida | 33321 | — |
| Local Institution - 0160 | Atlanta | Georgia | 30318 | — |
| Local Institution - 0205 | Suwanee | Georgia | 30024 | — |
| Local Institution - 0146 | Orland Park | Illinois | 60467 | — |
| Local Institution - 0187 | Hopkinsville | Kentucky | 42240 | — |
| Local Institution - 0171 | Baton Rouge | Louisiana | 70836 | — |
| Local Institution - 0134 | Wheaton | Maryland | 20902 | — |
| Local Institution - 0070 | Eagan | Minnesota | 55121 | — |
| Local Institution - 0124 | St Louis | Missouri | 63110 | — |
| Local Institution - 0165 | St Louis | Missouri | 63141 | — |
| Local Institution - 0091 | Las Vegas | Nevada | 89128 | — |
| Local Institution - 0219 | West Long Branch | New Jersey | 07764 | — |
| Local Institution - 0140 | Manhasset | New York | 11030 | — |
| Local Institution - 0132 | The Bronx | New York | 10461 | — |
| Local Institution - 0203 | Charlotte | North Carolina | 28204 | — |
| Local Institution - 0103 | Charlotte | North Carolina | 28211 | — |
| Local Institution - 0151 | Columbus | Ohio | 43203 | — |
| Local Institution - 0042 | Middleburg Heights | Ohio | 44130 | — |
| Local Institution - 0152 | Allen | Texas | 75013 | — |
| Local Institution - 0197 | Allen | Texas | 75013 | — |
| Local Institution - 0136 | Amarillo | Texas | 79124 | — |
| Local Institution - 0029 | Mesquite | Texas | 75150 | — |
| Local Institution - 0163 | San Antonio | Texas | 78215 | — |
| Local Institution - 0223 | Bellevue | Washington | 98004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 111 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04895696, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 17, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04895696 live on ClinicalTrials.gov.