ClinicalTrials.gov record
A Study of an Adenovirus Serotype 26 Pre-fusion Conformation-stabilized F Protein (Ad26. RSV. preF) Based Respiratory Syncytial Virus (RSV) Vaccine in the Prevention of Lower Respiratory Tract Disease in Adults Aged 60 Years and Older
ClinicalTrials.gov ID: NCT04908683
Public ClinicalTrials.gov record NCT04908683. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled Phase 3 Efficacy Study of an Ad26.RSV.preF-based Vaccine in the Prevention of Lower Respiratory Tract Disease Caused by RSV in Adults Aged 60 Years and Older
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study will enroll up to 27,200 participants in order to demonstrate the efficacy of the active Ad26.RSV.preF-based study vaccine in the prevention of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed Respiratory Syncytial Virus (RSV)-mediated Lower Respiratory Tract Disease (LRTD) when compared to placebo in adults aged 60 years and above.
Study identification
- NCT ID
- NCT04908683
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 25,236 participants
Conditions and interventions
Interventions
- Adenovirus serotype 26 (Ad26)-based respiratory syncytial virus (RSV). preF Biological
- Placebo Biological
Biological
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2021 (Actual)
- Primary completion
- Jul 21, 2023 (Actual)
- Completion
- Jul 21, 2023 (Actual)
- Last update posted
- Nov 13, 2025
2021 – 2023
United States locations
- U.S. sites
- 156
- U.S. states
- 36
- U.S. cities
- 129
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates, Inc. | Birmingham | Alabama | 35205 | — |
| Synexus Clinical Research US Inc | Birmingham | Alabama | 35211 | — |
| Achieve Clinical Research, LLC | Birmingham | Alabama | 35216 | — |
| Optimal Research | Huntsville | Alabama | 35802 | — |
| Coastal Clinical Research, Inc | Mobile | Alabama | 36608 | — |
| Synexus Clinical Research US Inc | Chandler | Arizona | 85224 | — |
| Hope Research Institute | Peoria | Arizona | 85381 | — |
| Central Phoenix Medical Clinic | Phoenix | Arizona | 85020 | — |
| Medpharmics, LLC | Phoenix | Arizona | 85379 | — |
| Clinical Research Consortium Arizona | Tempe | Arizona | 85283 | — |
| Synexus Clinical Research US Inc | Tucson | Arizona | 85741 | — |
| Baptist Health Center For Clinical Research | Little Rock | Arkansas | 72205 | — |
| Rancho Paseo Medical Group | Banning | California | 92220 | — |
| Hope clinical Research LLC | Canoga Park | California | 91303 | — |
| Synexus Clinical Research US Inc | Cerritos | California | 90703 | — |
| eStudySite | Chula Vista | California | 919111 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Paradigm Clinical Research Centers, Inc. | Redding | California | 96001 | — |
| Optimal Research | San Diego | California | 92108 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| Synexus Clinical Research US Inc | Vista | California | 92083 | — |
| Synexus Clinical Research US Inc | Aurora | Colorado | 80014 | — |
| Tekton Research Inc. | Fort Collins | Colorado | 80528 | — |
| Tekton Research Inc. | Longmont | Colorado | 80501 | — |
| Paradigm Clinical Research Centers, Inc. | Wheat Ridge | Colorado | 80033 | — |
| JEM Research LLC | Atlantis | Florida | 33462 | — |
| Clinical Research of South Florida, an AMR Company | Coral Gables | Florida | 33134 | — |
| Prestige Clinical Research Center, Inc. | Coral Gables | Florida | 33134 | — |
| Avail Clinical Research, LLC | DeLand | Florida | 32720 | — |
| Velocity Clinical Research, Inc. | Edgewater | Florida | 32132 | — |
| AMR Fort Myers Clinical Physiology Associates, an AMR company | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Center For Clinical Research | Jacksonville | Florida | 32216 | — |
| Altus Research, Inc | Lake Worth | Florida | 33461 | — |
| Accel Research Sites | Lakeland | Florida | 33803 | — |
| Compass Research LLC | Leesburg | Florida | 34748 | — |
| Optimal Research | Melbourne | Florida | 32934 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Suncoast Research Associates, LLC | Miami | Florida | 33173 | — |
| Clinical Site Partners, LLC | Miami | Florida | 33186 | — |
| Healthcare Clinical Data Inc. | North Miami | Florida | 33161 | — |
| Harmony Clinical Research Inc | North Miami Beach | Florida | 33162 | — |
| Clinical NeuroScience Solutions Inc | Orlando | Florida | 32801 | — |
| Headlands Research Orlando | Orlando | Florida | 32806 | — |
| Synexus Clinical Research US Inc | Orlando | Florida | 32806 | — |
| Synexus Clinical Research US Inc | Pinellas Park | Florida | 33781 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Sandhill Research | St. Petersburg | Florida | 33709 | — |
| DBC Research | Tamarac | Florida | 33321 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Synexus Clinical Research US Inc | Atlanta | Georgia | 30328 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| Accel Research Sites | Eatonton | Georgia | 31024 | — |
| Meridian Clinical Research, LLC | Savannah | Georgia | 31406 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Advanced Clinical Research | Boise | Idaho | 83642 | — |
| Christie Clinic | Champaign | Illinois | 61822 | — |
| Synexus Clinical Research US Inc | Chicago | Illinois | 60602 | — |
| Optimal Research | Peoria | Illinois | 61614 | — |
| Medisphere Medical Research Center, Llc | Evansville | Indiana | 47714 | — |
| The South Bend Clinic Center for Research | South Bend | Indiana | 46617-2808 | — |
| Buynak Clinical Research | Valparaiso | Indiana | 46383 | — |
| The Iowa Clinic, P.C. | West Des Moines | Iowa | 50266 | — |
| Heartland Research Associates, LLC | Augusta | Kansas | 67010 | — |
| Johnson County Clin-Trials | Lenexa | Kansas | 66219 | — |
| Heartland Research Associates, LLC | Newton | Kansas | 67114 | — |
| Heartland Clinical Research | Wichita | Kansas | 67207 | — |
| Central Kentucky Research Associates, Inc. | Lexington | Kentucky | 40509 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Medpharmics, LLC | Kenner | Louisiana | 70065 | — |
| Medpharmics, LLC | Lafayette | Louisiana | 70508 | — |
| Centex Studies, Inc. | Lake Charles | Louisiana | 70601 | — |
| Clinical Trials of America | Monroe | Louisiana | 71201 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| AMR New Orleans, Formerly New Orleans Center for Clinical Research - New Orleans, an AMR company | New Orleans | Louisiana | 70119 | — |
| Central Maine Medical Center | Lewiston | Maine | 04240 | — |
| Centennial Medical Group | Elkridge | Maryland | 21075 | — |
| Optimal Research | Rockville | Maryland | 20850 | — |
| Synexus Clinical Research US Inc | Richfield | Minnesota | 55423 | — |
| MedPharmics - Biloxi | Biloxi | Mississippi | 39531 | — |
| Jefferson City Medical Group Family | Jefferson City | Missouri | 65109 | — |
| The Center for Pharmaceutical Research (CPR) | Kansas City | Missouri | 64114 | — |
| Sundance Clinical Research | St Louis | Missouri | 63141 | — |
| Synexus Clinical Research US Inc | St Louis | Missouri | 63141 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Meridian Clinical Research, LLC | Norfolk | Nebraska | 68701 | — |
| Meridian Clinical Research - Omaha | Omaha | Nebraska | 68134 | — |
| Synexus Clinical Research US Inc | Omaha | Nebraska | 68144 | — |
| Synexus Clinical Research US Inc | Henderson | Nevada | 89052 | — |
| Clinical Research Consortium, an AMR company | Las Vegas | Nevada | 89119 | — |
| Medpharmics, LLC | Albuquerque | New Mexico | 87102 | — |
| Meridian Clinical Research, LLC | Endwell | New York | 13760 | — |
| Regional Clinical Research, Inc. | Endwell | New York | 13760 | — |
| Synexus Clinical Research US Inc | Manhattan | New York | 10017 | — |
| Harlem Hospital Center | New York | New York | 10027 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10312 | — |
| CHEAR Center, LLC | The Bronx | New York | 10455 | — |
| Accellacare Research of Cary | Cary | North Carolina | 27518 | — |
| American Health Network, LLC | Charlotte | North Carolina | 28277 | — |
| M3-Emerging Medical Research | Durham | North Carolina | 27704 | — |
| Medication Management LLC | Greensboro | North Carolina | 27401 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Accellacare Research of Cary | Raleigh | North Carolina | 27609 | — |
| Wake Research Associates | Raleigh | North Carolina | 27612 | — |
| PMG Research of Wilmington, LLC | Wilmington | North Carolina | 28401 | — |
| Trial Management Associates, LLC | Wilmington | North Carolina | 28401 | — |
| Accellacare Research of Cary | Winston-Salem | North Carolina | 27103 | — |
| Synexus Clinical Research US Inc | Akron | Ohio | 44311 | — |
| Synexus Clinical Research US Inc | Cincinnati | Ohio | 45236 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45242 | — |
| Rapid Medical Research | Cleveland | Ohio | 44122 | — |
| Synexus Clinical Research US Inc | Columbus | Ohio | 43212 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Tekton Research Inc. | Yukon | Oklahoma | 73099 | — |
| Clinical Research Institute of Southern Oregon, P.C. | Grants Pass | Oregon | 97527 | — |
| Clinical Research Institute of Southern Oregon, P.C. | Medford | Oregon | 97504 | — |
| Preferred Primary Care Physicians Research | Pittsburgh | Pennsylvania | 15243 | — |
| Preferred Primary Care Physicians Research | Uniontown | Pennsylvania | 15401 | — |
| Omega Medical Research | Warwick | Rhode Island | 02886 | — |
| Synexus Clinical Research US Inc | Anderson | South Carolina | 29621-2062 | — |
| Velocity Clinical Research, Inc. | Gaffney | South Carolina | 29340 | — |
| Coastal Carolina Research Center | Mt. Pleasant | South Carolina | 29464 | — |
| PMG Research of Charleston, LLC | Mt. Pleasant | South Carolina | 29464 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| VitaLink Research Spartanburg | Spartanburg | South Carolina | 29303 | — |
| Meridian Clinical Research - Dakota Dunes | Dakota Dunes | South Dakota | 57049 | — |
| PMG Research of Bristol | Bristol | Tennessee | 37620 | — |
| VGR & NOCCR - Knoxville | Knoxville | Tennessee | 37920 | — |
| Clinical Research Associates Inc | Nashville | Tennessee | 37203 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Optimal Research | Austin | Texas | 78705 | — |
| Tekton Research Inc. | Austin | Texas | 78745 | — |
| Tekton Research Inc. | Beaumont | Texas | 78745 | — |
| Advanced Clinical Research | Cedar Park | Texas | 78613 | — |
| Synexus Clinical Research US Inc | Dallas | Texas | 75231 | — |
| North Texas Infectious Diseases Consultants | Dallas | Texas | 75246 | — |
| Vilo Research Group Inc | Houston | Texas | 77017 | — |
| Texas Center for Drug Development Inc | Houston | Texas | 77081 | — |
| Research Your Health | Plano | Texas | 75093 | — |
| Clinical Trials of Texas Inc | San Antonio | Texas | 78229 | — |
| Synexus Clinical Research US Inc | San Antonio | Texas | 78229 | — |
| Tekton Research Inc. | San Antonio | Texas | 78240 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Martine Diagnostic Clinic | Tomball | Texas | 77375 | — |
| Synexus Clinical Research US Inc | Layton | Utah | 84041 | — |
| Synexus Clinical Research US Inc | Murray | Utah | 84123 | — |
| Advanced Clinical Research | West Jordan | Utah | 84088 | — |
| Charlottesville Medical Research Center, LLC | Charlottesville | Virginia | 22911 | — |
| Spectrum Medical, Inc | Danville | Virginia | 24541 | — |
| Health Research of Hampton Roads, Inc | Newport News | Virginia | 23606 | — |
| Clinical Research Associates of Tidewater | Norfolk | Virginia | 23507 | — |
| Amherst Family Practice, PC | Winchester | Virginia | 22601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 116 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04908683, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 13, 2025 · Synced Nov 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04908683 live on ClinicalTrials.gov.