Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

ClinicalTrials.gov ID: NCT04916210

Public ClinicalTrials.gov record NCT04916210. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.

Study identification

NCT ID: NCT04916210
Recruitment status: Recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: Massachusetts General Hospital; Other
Enrollment: 8,000 participants

Conditions and interventions

Conditions

Interventions

Not listed

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 5, 2021 (Actual)
Primary completion: Aug 31, 2027 (Estimated)
Completion: Aug 31, 2027 (Estimated)
Last update posted: Sep 14, 2026

2021 – 2027

United States locations

U.S. sites: 31
U.S. states: 21
U.S. cities: 27

Facility	City	State	ZIP	Site status
Barrow Neurological Institute	Phoenix	Arizona	85013	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Cedars Sinai Medical Center	Los Angeles	California	90048	Recruiting
University of California Los Angeles	Los Angeles	California	90095	Recruiting
University of California San Diego	San Diego	California	92037	Recruiting
University of Colorado	Denver	Colorado	80045	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
University of Miami Health System	Miami	Florida	33125	Recruiting
The University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
Indiana University	Indianapolis	Indiana	46202	Recruiting
University of Iowa	Iowa City	Iowa	52242	Active, not recruiting
University of Maryland Medical Center	Baltimore	Maryland	21201	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Active, not recruiting
University of Minnesota Health	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic	Rochester	Minnesota	55902	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Duke University Medical Center	Durham	North Carolina	27708	Recruiting
Wake Forest Baptist Health	Winston-Salem	North Carolina	27157	Active, not recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Recruiting
The Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Methodist University Hospital	Memphis	Tennessee	38104	Recruiting
Houston Methodist Research Institute	Houston	Texas	77030	Recruiting
UTHealth	Houston	Texas	77030	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
University of Utah	Salt Lake City	Utah	84132	Recruiting
University of Virginia	Charlottesville	Virginia	22903	Recruiting
University of Washington, Harborview Medical Center	Seattle	Washington	98104	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04916210, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 14, 2026 · Synced Oct 20, 2026

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