Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes
Public ClinicalTrials.gov record NCT04916470. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effect of Semaglutide 2.4 mg Once-weekly on Function and Symptoms in Subjects With Obesity-related Heart Failure With Preserved Ejection Fraction, and Type 2 Diabetes
Study identification
- NCT ID
- NCT04916470
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 617 participants
Conditions and interventions
Interventions
- Placebo (Semaglutide) Drug
- Semaglutide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 14, 2021
- Primary completion
- Oct 10, 2023
- Completion
- Oct 10, 2023
- Last update posted
- Nov 25, 2025
2021 – 2023
United States locations
- U.S. sites
- 54
- U.S. states
- 23
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eastern Shore Rsrch Inst, LLC | Fairhope | Alabama | 36532 | — |
| Mobile Heart Specialists | Mobile | Alabama | 36608 | — |
| National Heart Institute Cal | Beverly Hills | California | 90211 | — |
| John Muir Physicians Network | Concord | California | 94520 | — |
| Valley Clinical Trials | Covina | California | 91723 | — |
| Keck Medical Center of USC - Outpatient Clinic | Los Angeles | California | 90033 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Lundquist Inst-Biomed Innovtn | Torrance | California | 90502 | — |
| New West Physicians,Inc. | Golden | Colorado | 80401 | — |
| Excel Med Ctr Clinical Trials | Boca Raton | Florida | 33434 | — |
| Bay Area Cardiology Associates, P.A. | Brandon | Florida | 33511 | — |
| Baptist Heart Specialists_Jacksonville | Jacksonville | Florida | 32258 | — |
| CV Res Ctr of S Florida | Miami | Florida | 33173 | — |
| Endeavor Health Clinical Operations-NCH | Arlington Heights | Illinois | 60005 | — |
| Endeavor Health Glenbook Hosp | Evanston | Illinois | 60201 | — |
| Northwestern University_Chicago_0 | Evanston | Illinois | 60208 | — |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | — |
| Deaconess Specialty Physicians | Evansville | Indiana | 47747 | — |
| Ascension St. Vincent Medical Group | Indianapolis | Indiana | 46260 | — |
| Cardiovascular Rsrch of NW_IN | Munster | Indiana | 46321 | — |
| Cotton-O'Neil Heart Center | Topeka | Kansas | 66606 | — |
| Baptist Health Woodland | Elizabethtown | Kentucky | 42701 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| Baptist Health Louisville | Louisville | Kentucky | 40207 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| Clinical Trials of Ame, LLC | Monroe | Louisiana | 71201 | — |
| Grace Research, LLC_Shreveport | Shreveport | Louisiana | 71105 | — |
| Louisiana Heart Center_Slidell | Slidell | Louisiana | 70458 | — |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | — |
| MedStar Good Samaritan Hosp | Baltimore | Maryland | 21239 | — |
| John Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Univ of Mississippi Med Ctr | Jackson | Mississippi | 39216 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| St Louis Heart & Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Bryan Heart | Lincoln | Nebraska | 68506 | — |
| CHI Health Clinic Cardiology (CUMC - Bergan Mercy) | Omaha | Nebraska | 68124 | — |
| St Francis Hospital Lindner Research Center | Greenvale | New York | 11548 | — |
| NY Presbyt Hosp-W Cornell Med | New York | New York | 10021 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Lindner Center,Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Abington Memorial Hospital | Abington | Pennsylvania | 19001 | — |
| Hospital of University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Sanford Health_Sioux Falls | Sioux Falls | South Dakota | 57117 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Angio Cardiac Care of Texas | Houston | Texas | 77025 | — |
| Cardiology Consultants of Danville Inc. | Danville | Virginia | 24541 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298-5058 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 126 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04916470, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 25, 2025 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04916470 live on ClinicalTrials.gov.