Novel Experimental COVID-19 Therapies Affecting Host Response
Public ClinicalTrials.gov record NCT04924660. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CONNECTS Master Protocol for Clinical Trials Targeting Macro-, Micro-immuno-thrombosis, Vascular Hyperinflammation, and Hypercoagulability and Renin-angiotensin-aldosterone System (RAAS) in Hospitalized Patients With COVID-19 (ACTIV-4 Host Tissue)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing progression to critical illness, multiorgan failure, or death. Our objective is to determine whether modulating the host tissue response improves clinical outcomes among patients with COVID-19. The primary analysis will include data from NCT05593770.
Study identification
- NCT ID
- NCT04924660
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 1,060 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 15, 2021 (Actual)
- Primary completion
- Oct 25, 2023 (Actual)
- Completion
- Dec 31, 2023 (Actual)
- Last update posted
- Jan 22, 2025
2021 – 2023
United States locations
- U.S. sites
- 51
- U.S. states
- 26
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Birmingham | Birmingham | Alabama | 35249 | — |
| Chandler Regional Medical Center | Chandler | Arizona | 85224 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80010 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Public Health Trust of Miami-Dade County, Florida - Jackson Memorial Hospital | Miami | Florida | 33136 | — |
| Ponce de Leon Clinical Research Site | Atlanta | Georgia | 30303 | — |
| Emory Johns Creek | Atlanta | Georgia | 30322 | — |
| Emory St. Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Alexian Brothers Medical Center | Elk Grove Village | Illinois | 60007 | — |
| AMITA Health St. Alexius Medical Center | Hoffman Estates | Illinois | 60169 | — |
| Our Lady of the Lake Regional Medical Center | Baton Rouge | Louisiana | 70808 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Jadestone Clinical Research, LLC | Silver Spring | Maryland | 20904 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02072 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Newton-Wellesley Hospital | Newton | Massachusetts | 02462 | — |
| Baystate Health | Springfield | Massachusetts | 01119 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| University of New Mexico Health Sciences Center | Albuquerque | New Mexico | 87106 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Irving Medical Center | New York | New York | 10032 | — |
| Montefiore Medical Center Weiler Campus | The Bronx | New York | 10461 | — |
| Montefiore Medical Center Moses Campus | The Bronx | New York | 10467 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44321 | — |
| University of Cincinnati | Cincinnati | Ohio | 45229 | — |
| Cleveland Clinic Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| West Chester Hospital | West Chester | Ohio | 45069 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37203 | — |
| University of Texas, Houston | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Health | Salt Lake City | Utah | 84108 | — |
| UVA Health | Charlottesville | Virginia | 22908 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| VCU Health | Richmond | Virginia | 23298 | — |
| Harborview Medical Center/University of Washington | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04924660, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 22, 2025 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04924660 live on ClinicalTrials.gov.