ClinicalTrials.gov record
Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative
ClinicalTrials.gov ID: NCT04929041
Public ClinicalTrials.gov record NCT04929041. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 20, 2026, 2:10 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without Radiation Therapy for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
Study identification
- NCT ID
- NCT04929041
- Recruitment status
- Suspended
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 427 participants
Conditions and interventions
Conditions
Interventions
- Biopsy Procedure Procedure
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Echocardiography Test Procedure
- Ipilimumab Biological
- Magnetic Resonance Imaging Procedure
- Nivolumab Biological
- Positron Emission Tomography Procedure
- Quality-of-Life Assessment Other
- Radiation Therapy Radiation
Procedure · Biological · Other + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 6, 2022
- Primary completion
- Dec 11, 2030
- Completion
- Dec 11, 2030
- Last update posted
- May 12, 2026
2022 – 2030
United States locations
- U.S. sites
- 170
- U.S. states
- 30
- U.S. cities
- 133
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | — |
| City of Hope Antelope Valley | Lancaster | California | 93534 | — |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Providence Queen of The Valley | Napa | California | 94558 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| City of Hope South Pasadena | South Pasadena | California | 91030 | — |
| Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee | California | 96161 | — |
| City of Hope Upland | Upland | California | 91786 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Memorial Hospital North | Colorado Springs | Colorado | 80920 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | 80528 | — |
| UCHealth Greeley Hospital | Greeley | Colorado | 80631 | — |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Beebe South Coastal Health Campus | Millville | Delaware | 19967 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| UM Sylvester Comprehensive Cancer Center at Aventura | Aventura | Florida | 33180 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | 33607 | — |
| Winter Haven Hospital | Winter Haven | Florida | 33881 | — |
| CTCA at Southeastern Regional Medical Center | Newnan | Georgia | 30265 | — |
| Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah | Georgia | 31405 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | — |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | — |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | — |
| UW Health Carbone Cancer Center Rockford | Rockford | Illinois | 61114 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| UChicago Medicine Northwest Indiana | Crown Point | Indiana | 46307 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | — |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | — |
| Greater Regional Medical Center | Creston | Iowa | 50801 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | — |
| Mercy Medical Center-West Lakes | West Des Moines | Iowa | 50266 | — |
| The Iowa Clinic PC | West Des Moines | Iowa | 50266 | — |
| Saint Joseph Hospital East | Lexington | Kentucky | 40509 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| MaineHealth Cancer Care Center of York County | Sanford | Maine | 04073 | — |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | — |
| MaineHealth Cancer Care and IV Therapy - South Portland | South Portland | Maine | 04106 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Genesys Hurley Cancer Institute | Flint | Michigan | 48503 | — |
| Hurley Medical Center | Flint | Michigan | 48503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Michigan Healthcare Professionals Pontiac | Pontiac | Michigan | 48341 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| MyMichigan Medical Center Saginaw | Saginaw | Michigan | 48601 | — |
| Oncology Hematology Associates of Saginaw Valley PC | Saginaw | Michigan | 48604 | — |
| MyMichigan Medical Center Tawas | Tawas City | Michigan | 48764 | — |
| Saint Mary's Oncology/Hematology Associates of West Branch | West Branch | Michigan | 48661 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Phelps Health Delbert Day Cancer Institute | Rolla | Missouri | 65401 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| BJC Outpatient Center at Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Northwell Health/Center for Advanced Medicine | Lake Success | New York | 11042 | — |
| Mount Sinai Chelsea | New York | New York | 10011 | — |
| Mount Sinai West | New York | New York | 10019 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Manhattan Eye Ear and Throat Hospital | New York | New York | 10065 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Upstate Cancer Center at Oswego | Oswego | New York | 13126 | — |
| Upstate Cancer Center Radiation Oncology at Oswego | Oswego | New York | 13126 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Upstate Cancer Center at Hill Radiation Oncology | Syracuse | New York | 13210 | — |
| SUNY Upstate Medical Center-Community Campus | Syracuse | New York | 13215 | — |
| Upstate Cancer Center at Verona | Verona | New York | 13478 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Duke Cancer Center Raleigh | Raleigh | North Carolina | 27609 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Summa Health System - Akron Campus | Akron | Ohio | 44304 | — |
| Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | 73505 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | — |
| Legacy Mount Hood Medical Center | Gresham | Oregon | 97030 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Legacy Meridian Park Hospital | Tualatin | Oregon | 97062 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| Penn State Health Saint Joseph Medical Center | Reading | Pennsylvania | 19605 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| The Don and Sybil Harrington Cancer Center | Amarillo | Texas | 79106 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| VCU Health Tappahannock Hospital | Tappahannock | Virginia | 22560 | — |
| Legacy Cancer Institute Medical Oncology and Day Treatment | Vancouver | Washington | 98684 | — |
| Legacy Salmon Creek Hospital | Vancouver | Washington | 98686 | — |
| Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | 99362 | — |
| West Virginia University Charleston Division | Charleston | West Virginia | 25304 | — |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | — |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Mayo Clinic Health System-Franciscan Healthcare | La Crosse | Wisconsin | 54601 | — |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | — |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | — |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | — |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04929041, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 12, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04929041 live on ClinicalTrials.gov.