Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx
Public ClinicalTrials.gov record NCT04935177. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-label, Controlled, Randomized Phase 3 Trial Evaluating 12-month Kidney Function in Highly Sensitized (cPRA ≥99.9%) Kidney Tx Patients With Positive XM Against a Deceased Donor, Comparing Desensitization Using Imlifidase With SoC
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
An open-label, controlled, randomized Phase 3 trial evaluating 12-month kidney function in highly sensitized (cPRA ≥99.9%) kidney transplant patients with positive crossmatch against a deceased donor, comparing desensitization using imlifidase with standard of care
Study identification
- NCT ID
- NCT04935177
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 64 participants
Conditions and interventions
Interventions
- Imlifidase Drug
- PLEX Procedure
- IVIg Drug
- Anti-CD20 antibodies Drug
- Eculizumab Drug
- Remain on wait list Other
Drug · Procedure · Other
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 14, 2021 (Actual)
- Primary completion
- Jun 20, 2025 (Actual)
- Completion
- Jun 20, 2025 (Actual)
- Last update posted
- Apr 30, 2026
2021 – 2025
United States locations
- U.S. sites
- 25
- U.S. states
- 16
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (UAB) Hospital | Birmingham | Alabama | 35249 | — |
| Banner Health - University Medical Center - Phoenix | Phoenix | Arizona | 85006 | — |
| Mayo Clinic Phoenix | Phoenix | Arizona | 85054 | — |
| Keck Hospital of University of Southern California (USC) | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Sutter Health - California Pacific Medical Center | San Francisco | California | 94115 | — |
| University of California San Francisco (UCSF) Medical Center | San Francisco | California | 94143-0780 | — |
| Georgetown Transplant Institute | Washington D.C. | District of Columbia | 20007 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| John Hopkins Hospital | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Minnesota Medical School | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| New York University (NYU) Langone Transplant Institute, NYU Langone Health | New York | New York | 10016 | — |
| Columbia University | New York | New York | 10032 | — |
| New York-Presbyterian - Weill Cornell Medical Center | New York | New York | 10065 | — |
| Hospital of the University of Pennsylvania, Penn Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Methodist Hospital Specialty and Transplant | San Antonio | Texas | 78229 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04935177, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04935177 live on ClinicalTrials.gov.