Study of MK-4482 for Prevention of Coronavirus Disease 2019 (COVID-19) in Adults (MK-4482-013)
Public ClinicalTrials.gov record NCT04939428. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-4482 for the Prevention of COVID-19 (Laboratory-confirmed SARS-CoV-2 Infection With Symptoms) in Adults Residing With a Person With COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to assess if the study medication (molnupiravir, MK-4482) will prevent symptomatic coronavirus disease 2019 (COVID-19) in adults who live with someone with confirmed COVID-19 infection. This is a phase 3, multicenter, randomized, double-blind, placebo-controlled study; half of the study participants will receive molnupiravir twice daily by mouth and the other half will receive a placebo. The primary objectives of the study are to determine if molnupiravir prevents symptomatic COVID-19 disease and to evaluate its safety and tolerability. All participants who develop COVID-19 during the study are still eligible for any COVID-19 treatment recommended by their doctor.
Study identification
- NCT ID
- NCT04939428
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,441 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 11, 2021 (Actual)
- Primary completion
- Nov 16, 2022 (Actual)
- Completion
- Nov 16, 2022 (Actual)
- Last update posted
- Sep 26, 2024
2021 – 2022
United States locations
- U.S. sites
- 59
- U.S. states
- 29
- U.S. cities
- 56
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cahaba Research, Inc. ( Site 2523) | Birmingham | Alabama | 35235 | — |
| The Institute for Liver Health DBA Arizona Clinical Trials ( Site 2484) | Mesa | Arizona | 85210 | — |
| The Institute for Liver Health DBA Arizona Clinical Trials ( Site 2448) | Tucson | Arizona | 85712 | — |
| Hope Clinical Research ( Site 2400) | Canoga Park | California | 91303 | — |
| Carbon Health ( Site 2515) | Carlsbad | California | 92009 | — |
| UCSF Fresno ( Site 2528) | Fresno | California | 93701 | — |
| ASCADA Research, LLC ( Site 2516) | Fullerton | California | 92835 | — |
| Marvel Clinical Research ( Site 2490) | Huntington Beach | California | 92647 | — |
| National Research Institute ( Site 2452) | Los Angeles | California | 90057 | — |
| Valley Clinical Trials Inc. ( Site 2406) | Northridge | California | 91325 | — |
| Carbon Health ( Site 2514) | Oakland | California | 94610 | — |
| University of California Davis ( Site 2497) | Sacramento | California | 95817 | — |
| Millennium Clinical Trials ( Site 2468) | Simi Valley | California | 93065 | — |
| Future Innovative Treatments, LLC ( Site 2471) | Colorado Springs | Colorado | 80907 | — |
| Emerson Clinical Research Institute ( Site 2457) | Washington D.C. | District of Columbia | 20011 | — |
| Synergy Healthcare ( Site 2521) | Bradenton | Florida | 34208 | — |
| Accel Research Sites-DeLand Clinical Research Unit ( Site 2535) | DeLand | Florida | 32720 | — |
| Velocity Clinical Research, Hallandale Beach ( Site 2485) | Hallandale | Florida | 33009 | — |
| Indago Research and Health Center Inc ( Site 2412) | Hialeah | Florida | 33012 | — |
| Advanced Research For Health Improvement LLC ( Site 2436) | Immokalee | Florida | 34142 | — |
| Clinical Site Partners, LLC d/b/a CSP Miami ( Site 2508) | Miami | Florida | 33186 | — |
| CDC Research Institute, LLC ( Site 2540) | Port Saint Lucie | Florida | 34952 | — |
| Clinical Research Trials of Florida ( Site 2402) | Tampa | Florida | 33607 | — |
| Clinical Site Partners, LLC d/b/a CSP Miami ( Site 2425) | Winter Park | Florida | 32789 | — |
| Balanced Life Healthcare Solutions/SKYCRNG ( Site 2539) | Lawrenceville | Georgia | 30046 | — |
| Chicago Clinical Research Institute Inc ( Site 2454) | Chicago | Illinois | 60607 | — |
| Rush University Medical Center ( Site 2510) | Chicago | Illinois | 60612 | — |
| Southern Clinical Research Associates ( Site 2542) | Metairie | Louisiana | 70001 | — |
| MedPharmics, LLC ( Site 2443) | Metairie | Louisiana | 70006 | — |
| Institute of Human Virology ( Site 2504) | Baltimore | Maryland | 21201 | — |
| Centennial Medical Group ( Site 2435) | Elkridge | Maryland | 21075 | — |
| Jadestone Clinical Research, LLC ( Site 2530) | Silver Spring | Maryland | 20904 | — |
| Michigan Center of Medical Research ( Site 2445) | Farmington Hills | Michigan | 48334 | — |
| Michigan Center of Medical Research ( Site 2525) | Lathrup Village | Michigan | 48076 | — |
| Allina Health Infectious Diseases Research Clinic ( Site 2507) | Minneapolis | Minnesota | 55404 | — |
| Prime Health and Wellness/SKYCRNG ( Site 2538) | Fayette | Mississippi | 39069 | — |
| Quinn Healthcare/Skycrng ( Site 2537) | Ridgeland | Mississippi | 39157 | — |
| University of Missouri Hospital ( Site 2486) | Columbia | Missouri | 65201 | — |
| Mercury Street Medical Group PLLC ( Site 2476) | Butte | Montana | 59701 | — |
| University of Nebraska Medical Center ( Site 2430) | Omaha | Nebraska | 68198-3135 | — |
| Excel Clinical Research, LLC ( Site 2404) | Las Vegas | Nevada | 89109 | — |
| ID Care ( Site 2466) | Hillsborough | New Jersey | 08844 | — |
| Amici Clinical Research LLC ( Site 2426) | Raritan | New Jersey | 08869 | — |
| AXCES Research Group ( Site 2437) | Santa Fe | New Mexico | 87505 | — |
| Montefiore Medical Center ( Site 2503) | The Bronx | New York | 10462 | — |
| ECU Adult Specialty Care ( Site 2415) | Greenville | North Carolina | 27834 | — |
| The Lindner Center for Research and Education at The Christ Hospital ( Site 2517) | Cincinnati | Ohio | 45219 | — |
| Dayton Clinical Research ( Site 2488) | Dayton | Ohio | 45406 | — |
| Cherokee Nation WW Hastings Indian Hospital/Cherokee Nation Health Services ( Site 2459) | Tahlequah | Oklahoma | 74464 | — |
| Preferred Clinical Research ( Site 2470) | Pittsburgh | Pennsylvania | 15236 | — |
| Velocity Clinical Research-Providence ( Site 2432) | East Greenwich | Rhode Island | 02818 | — |
| Tribe Clinical Research, LLC ( Site 2409) | Greenville | South Carolina | 29607 | — |
| PharmaTex Research, LLC ( Site 2541) | Amarillo | Texas | 79109 | — |
| TTS Research ( Site 2433) | Boerne | Texas | 78006 | — |
| Houston Methodist Hospital ( Site 2463) | Houston | Texas | 77030 | — |
| Santa Clara Family Clinic ( Site 2462) | Houston | Texas | 77087 | — |
| Crossroads Clinical Research LLC ( Site 2451) | Victoria | Texas | 77901 | — |
| TPMG Clinical Research ( Site 2495) | Williamsburg | Virginia | 23188 | — |
| Covid-19 Clinical Research Center (CCRC) ( Site 2421) | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 167 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04939428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 26, 2024 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04939428 live on ClinicalTrials.gov.