A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)
Public ClinicalTrials.gov record NCT04945460. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of Sotatercept Versus Placebo for the Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension (Cpc-PH) Due to Heart Failure With Preserved Ejection Fraction (HFpEF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. The objective of this study is to evaluate the efficacy, safety and tolerability of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. Efficacy is measured by change from baseline in pulmonary vascular resistance (PVR, primary endpoint) and 6-minute walk distance (6MWD, key secondary endpoint).
Study identification
- NCT ID
- NCT04945460
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
- Industry
- Enrollment
- 165 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 29, 2021 (Actual)
- Primary completion
- Sep 5, 2025 (Actual)
- Completion
- Apr 9, 2026 (Actual)
- Last update posted
- Sep 23, 2026
2021 – 2026
United States locations
- U.S. sites
- 56
- U.S. states
- 32
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| PULMONARY ASSOCIATES, P.A. ( Site 1008) | Phoenix | Arizona | 85032 | — |
| University of Arizona ( Site 1006) | Tucson | Arizona | 85724-0001 | — |
| Scripps Clinic ( Site 4001) | La Jolla | California | 92037-1205 | — |
| Cedars Sinai Medical Center ( Site 1082) | Los Angeles | California | 90048 | — |
| University of California Irvine ( Site 1086) | Orange | California | 92868 | — |
| Jeffrey S.Sager MD Medical Corporation ( Site 1060) | Santa Barbara | California | 93105-5311 | — |
| Stanford University ( Site 1024) | Stanford | California | 94305 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 1028) | Torrance | California | 90502 | — |
| University Of Colorado ( Site 1013) | Aurora | Colorado | 80045 | — |
| South Denver Cardiology Associates ( Site 1091) | Littleton | Colorado | 80120 | — |
| Winchester Chest Clinic ( Site 1093) | New Haven | Connecticut | 06519-1304 | — |
| The George Washington University Medical Faculty Associates ( Site 1025) | Washington D.C. | District of Columbia | 20037-3201 | — |
| Bay Area Cardiology ( Site 1071) | Brandon | Florida | 33511 | — |
| Mayo Clinic Jacksonville - PPDS ( Site 1045) | Jacksonville | Florida | 32224 | — |
| AdventHealth Orlando ( Site 1058) | Orlando | Florida | 32803 | — |
| Tampa General Hospital ( Site 1043) | Tampa | Florida | 33606 | — |
| Piedmont Atlanta Hospital ( Site 1085) | Atlanta | Georgia | 30309-1281 | — |
| Emory University ( Site 1030) | Atlanta | Georgia | 30322-1013 | — |
| Saint Alphonsus Regional Medical Center ( Site 1097) | Boise | Idaho | 83704-8880 | — |
| University of Illinois Hospital ( Site 1095) | Chicago | Illinois | 60612 | — |
| IU Health Advanced Heart and Lung Care ( Site 1092) | Indianapolis | Indiana | 46202-1218 | — |
| Ascension Medical Group St. Vincent ( Site 1076) | Indianapolis | Indiana | 46260 | — |
| University of Iowa Hospital and Clinics ( Site 1050) | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center ( Site 1020) | Kansas City | Kansas | 66160 | — |
| Norton Pulmonary Specialists ( Site 1066) | Louisville | Kentucky | 40202 | — |
| University of Louisville ( Site 1099) | Louisville | Kentucky | 40202 | — |
| University Medical Center New Orleans ( Site 1057) | New Orleans | Louisiana | 70112 | — |
| Tufts Medical Center - PPDS ( Site 1012) | Boston | Massachusetts | 02111 | — |
| Brigham and Women's Hospital [Boston, MA] ( Site 1014) | Boston | Massachusetts | 02115 | — |
| University of Michigan ( Site 1011) | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota Hospitals ( Site 1062) | Minneapolis | Minnesota | 55455 | — |
| Washington University School of Medicine [Saint Louis, MO] ( Site 1022) | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center ( Site 1053) | Omaha | Nebraska | 68198 | — |
| Pulmonary Health Physicians ( Site 1080) | Liverpool | New York | 13088 | — |
| Weill Cornell Medical College ( Site 1046) | New York | New York | 10021-9800 | — |
| University of Rochester Medical Center - PPDS ( Site 1039) | Rochester | New York | 14642 | — |
| Duke University Medical Center ( Site 1026) | Durham | North Carolina | 27710-4000 | — |
| The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital ( Site 1001) | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center ( Site 1005) | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation ( Site 1065) | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center ( Site 1032) | Columbus | Ohio | 43210 | — |
| University of Toledo Medical Center ( Site 1070) | Toledo | Ohio | 43614 | — |
| Oregon Health Science University ( Site 1054) | Portland | Oregon | 97126 | — |
| Allegheny General Hospital ( Site 1088) | Pittsburgh | Pennsylvania | 15212-4737 | — |
| Lankenau Institute for Medical Research ( Site 1089) | Wynnewood | Pennsylvania | 19096 | — |
| Rhode Island Hospital ( Site 1033) | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina - PPDS ( Site 1003) | Charleston | South Carolina | 29425-0001 | — |
| Statcare Pulmonary Consultants - Knoxville ( Site 1031) | Knoxville | Tennessee | 37919 | — |
| Baylor University Medical Center ( Site 1096) | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center ( Site 4002) | Dallas | Texas | 75390 | — |
| Intermountain Medical Center ( Site 1079) | Murray | Utah | 84107 | — |
| Inova Heart and Vascular Institute ( Site 1078) | Falls Church | Virginia | 22042 | — |
| Bon Secours St. Mary's Hospital ( Site 1069) | Richmond | Virginia | 23226 | — |
| West Virginia University ( Site 1081) | Morgantown | West Virginia | 26506 | — |
| Aurora St Luke's Medical Center ( Site 1083) | Milwaukee | Wisconsin | 53215 | — |
| Froedtert Hospital & the Medical College of Wisconsin ( Site 1051) | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04945460, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 23, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04945460 live on ClinicalTrials.gov.