ClinicalTrials.gov record
A Phase 3 Study to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
ClinicalTrials.gov ID: NCT04951219
Public ClinicalTrials.gov record NCT04951219. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 52-Week, Phase 3, Open-Label Extension Study, With a Double-blind Lead-in, to Evaluate Safety and Biomarkers of Resmetirom (MGL-3196) in Patients With Non-alcoholic Fatty Liver Disease (NAFLD), MAESTRO-NAFLD-Open-Label-Extension (MAESTRO-NAFLD-OLE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A 52-Week, Multi-center, Open-label, Active Treatment Extension Study to Evaluate Safety and Tolerability of Once Daily, Oral Administration of Resmetirom (MGL-3196)
Study identification
- NCT ID
- NCT04951219
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 810 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 8, 2021
- Primary completion
- Feb 28, 2027
- Completion
- Mar 31, 2027
- Last update posted
- May 26, 2026
2021 – 2027
United States locations
- U.S. sites
- 75
- U.S. states
- 24
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Research Associates | Birmingham | Alabama | 35205 | — |
| Arizona Liver Health - Chandler | Chandler | Arizona | 85224 | — |
| East Valley Family Physicians | Chandler | Arizona | 85224 | — |
| The Institute For Liver Health - Glendale | Glendale | Arizona | 85306 | — |
| The Institute For Liver Health - Tucson | Tucson | Arizona | 85711 | — |
| Adobe Gastroenterology | Tucson | Arizona | 85712 | — |
| Arkansas Gastroenterology | North Little Rock | Arkansas | 72117 | — |
| Fresno Clinical Research Center | Fresno | California | 93720 | — |
| National Research Institute - Huntington Park | Huntington Park | California | 90255 | — |
| Ruane Clinical Research Group | Los Angeles | California | 90036 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| National Research Institute - Los Angeles | Los Angeles | California | 90057 | — |
| National Research Institute - Panorama City | Panorama City | California | 91402 | — |
| San Fernando Valley Health Institute | West Hills | California | 91307 | — |
| South Denver Gastroenterology - Swedish Medical Center Office | Englewood | Colorado | 80113 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Covenant Research | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research, Hallandale Beach (MD Clinical) | Hallandale | Florida | 33009 | — |
| Floridian Clinical Research | Hialeah | Florida | 33016 | — |
| Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| Floridian Clinical Research | Miami Lakes | Florida | 33016 | — |
| Orlando Research Center | Orlando | Florida | 32806 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Covenant Research | Sarasota | Florida | 34240 | — |
| The Villages Research Center | The Villages | Florida | 32162 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Chicago Research Center | Chicago | Illinois | 60602 | — |
| Northwestern Memorial Physicians Group | Chicago | Illinois | 60611 | — |
| Iowa Diabetes Research | West Des Moines | Iowa | 50265 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| Kansas Medical Clinic - Gastroenterology | Topeka | Kansas | 66606 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Rovia Clinical Research | Bastrop | Louisiana | 71220 | — |
| Digestive Health Center of Louisiana | Baton Rouge | Louisiana | 70809 | — |
| Tandem Clinical Research - New Orleans Area Site | Marrero | Louisiana | 70072 | — |
| Clinical Trials of America | West Monroe | Louisiana | 71291 | — |
| Gastrointestinal Associates & Endoscopy Center - Flowood | Flowood | Mississippi | 39232 | — |
| Southern Therapy and Advanced Research | Jackson | Mississippi | 39216 | — |
| Kansas City Research Institute | Kansas City | Missouri | 64131 | — |
| Henderson Research Center | Henderson | Nevada | 89052 | — |
| Clarity Clinical Research | East Syracuse | New York | 13057 | — |
| Velocity Clinical Research | East Syracuse | New York | 13057 | — |
| Mount Sinai Health System | New York | New York | 10029 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Cumberland Research Associates | Fayetteville | North Carolina | 28304 | — |
| Lucas Research | Moorehead City | North Carolina | 28557 | — |
| Diabetes and Endocrinology Consultants | Morehead City | North Carolina | 28557 | — |
| Aventiv Research Columbus | Columbus | Ohio | 43213 | — |
| Awasty Research Network | Marion | Ohio | 43302 | — |
| Innovative Clinical Research | Clarksville | Tennessee | 37040 | — |
| Gastro One - Germantown Office - Wolf Park Drive | Germantown | Tennessee | 38138 | — |
| Pinnacle Clinical Research - Austin | Austin | Texas | 78746 | — |
| The Liver Institute At Methodist Dallas | Dallas | Texas | 75203 | — |
| Dallas Research Center | Dallas | Texas | 75234 | — |
| Liver Center of Texas | Dallas | Texas | 75234 | — |
| South Texas Research Institute | Edinburg | Texas | 78539 | — |
| Texas Digestive Disease Consultants | Fort Worth | Texas | 76104 | — |
| Liver Associates of Texas | Houston | Texas | 77030 | — |
| Doctor's Hospital at Renaissance | McAllen | Texas | 78504 | — |
| Plano Research Center | Plano | Texas | 75093 | — |
| Texas Liver Institute/American Research Corporation | San Antonio | Texas | 78215 | — |
| Pinnacle Clinical Research - San Antonio | San Antonio | Texas | 78229 | — |
| San Antonio Research Center | San Antonio | Texas | 78229 | — |
| Texas Digestive Disease Consultants - San Marcos | San Marcos | Texas | 78666 | — |
| Impact Research Institute | Waco | Texas | 76710 | — |
| Texas Digestive Disease Consultants - Bay Area Houston Endoscopy Center | Webster | Texas | 77598 | — |
| Wasatch Peak Family Practice | Layton | Utah | 84041 | — |
| Salt Lake City Research Center | Murray | Utah | 84123 | — |
| Bon Secours Liver Institute of Richmond | Richmond | Virginia | 23226 | — |
| National Clinical Research - Richmond | Richmond | Virginia | 23294 | — |
| Virginia Commonwealth University School of Medicine | Richmond | Virginia | 23298 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
Recently updated Non-Alcoholic Fatty Liver Disease trials
Other public records listing Non-Alcoholic Fatty Liver Disease. Sorted by last update posted; newest first. Not a recommendation.
- NCT06005012: Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM Active, not recruiting
- NCT07403604: Effect of Insulin Lowering on Lipogenesis Recruiting
- NCT05583344: Phase 2b Study of GSK4532990 in Adults With NASH Active, not recruiting
- NCT03884075: Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES) Recruiting
- NCT07221227: A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH Recruiting
- NCT07221188: A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH Recruiting
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04951219, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 26, 2026 · Synced Aug 1, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04951219 live on ClinicalTrials.gov.