Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathy
Public ClinicalTrials.gov record NCT04957758. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Phase 2, Multicenter, Randomized, Controlled, Double-Masked, Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray in Subjects With Neurotrophic Keratopathy (the Olympia Study)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray as compared to placebo nasal spray for mean change from baseline in corneal fluorescein staining in subjects with Stage 1 (corneal epithelial hyperplasia/punctate keratopathy) neurotrophic keratopathy (NK) in one or both eyes.
Study identification
- NCT ID
- NCT04957758
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 113 participants
Conditions and interventions
Conditions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 17, 2021 (Actual)
- Primary completion
- Jan 27, 2023 (Actual)
- Completion
- Apr 28, 2023 (Actual)
- Last update posted
- May 7, 2024
2021 – 2023
United States locations
- U.S. sites
- 31
- U.S. states
- 18
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Dothan Alabama | Dothan | Alabama | 36301 | — |
| Irvine, California | Irvine | California | 92697 | — |
| Los Angeles California | Los Angeles | California | 90095 | — |
| Mission Hills California | Mission Hills | California | 91345 | — |
| Aurora Colorado | Aurora | Colorado | 80045 | — |
| Littleton, Colorado | Littleton | Colorado | 80120 | — |
| Longmont, Colorado | Longmont | Colorado | 80503 | — |
| Danbury, Connecticut | Danbury | Connecticut | 06810 | — |
| Brandon Florida | Brandon | Florida | 33511 | — |
| Brandon, Florida | Brandon | Florida | 33511 | — |
| Jacksonville Florida | Jacksonville | Florida | 32256 | — |
| Miami Florida | Miami | Florida | 33136 | — |
| Atlanta, Georgia | Atlanta | Georgia | 30339 | — |
| Hoffman Estates, Illinois | Hoffman Estates | Illinois | 60169 | — |
| Urbana Illinois | Urbana | Illinois | 61801 | — |
| Union Kentucky | Edgewood | Kentucky | 41017 | — |
| Louisville KY | Louisville | Kentucky | 40206 | — |
| Bowie, Maryland | Bowie | Maryland | 20716 | — |
| Boston Massachusetts | Boston | Massachusetts | 02114 | — |
| Kansas City Missouri | Kansas City | Missouri | 64111 | — |
| Henderson Nevada | Henderson | Nevada | 89052 | — |
| Bloomfield, New Jersey | Bloomfield | New Jersey | 07003 | — |
| Dover New Jersey | Dover | New Jersey | 07801 | — |
| Babylon New York | Babylon | New York | 11702 | — |
| New York NY | New York | New York | 10029 | — |
| York, Pennsylvania | York | Pennsylvania | 17408 | — |
| Houston Texas | Houston | Texas | 77030 | — |
| Katy, Texas | Katy | Texas | 77494 | — |
| San Antonio Texas | San Antonio | Texas | 78229 | — |
| Lynchburg Virginia | Lynchburg | Virginia | 24502 | — |
| Seattle Washington | Seattle | Washington | 98119 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04957758, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2024 · Synced Nov 4, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04957758 live on ClinicalTrials.gov.