A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
Public ClinicalTrials.gov record NCT04961996. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Patients With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with physician's choice of endocrine therapy in participants with medium- and high-risk Stage I-III histologically confirmed estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.
Study identification
- NCT ID
- NCT04961996
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,170 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 27, 2021 (Actual)
- Primary completion
- Aug 8, 2025 (Actual)
- Completion
- Sep 30, 2033 (Estimated)
- Last update posted
- Oct 15, 2026
2021 – 2033
United States locations
- U.S. sites
- 72
- U.S. states
- 31
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center | Daphne | Alabama | 36526 | — |
| CBCC Global Research Inc., at Comprehensive Blood and Cancer Center | Bakersfield | California | 93309 | — |
| St Joseph Heritage Healthcare | Fullerton | California | 92835 | — |
| Long Beach Memorial Medical Center | Long Beach | California | 90806 | — |
| Cancer and Blood Specialty Clinic-California-Katella Ave | Los Alamitos | California | 90720 | — |
| The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange | Orange | California | 92868 | — |
| Kaiser Permanente - San Diego | San Diego | California | 92120 | — |
| Sansum Clinic | Santa Barbara | California | 93105 | — |
| UCLA Hematology/Oncology | Santa Monica | California | 90404 | — |
| Torrance Memorial Physician Network/Cancer Care | Torrance | California | 90505 | — |
| Kaiser Permanente - Vallejo | Vallejo | California | 94589 | — |
| Rocky Mountain Cancer Centers (Longmont) - USOR | Longmont | Colorado | 80501 | — |
| Stamford Hospital | Stamford | Connecticut | 06902 | — |
| Memorial Healthcare System - Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Baptist - MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| University of Chicago Hospital | Chicago | Illinois | 60637 | — |
| Duly Health and Care | Tinley Park | Illinois | 60487 | — |
| Cancer Center of Kansas - Kingman | Kingman | Kansas | 67068 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Norton Cancer Institute - MDC | Louisville | Kentucky | 40202 | — |
| Hematology/Oncology Clinic, LLP | Baton Rouge | Louisiana | 70809 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| University of Maryland | Towson | Maryland | 21204 | — |
| Lahey Clinic Med Ctr | Burlington | Massachusetts | 01805 | — |
| Massachusetts General Hospital | Lexington | Massachusetts | 02421 | — |
| University Of Michigan | Ann Arbor | Michigan | 48109 | — |
| Metro-Minnesota Community Oncology Research Consortium | Saint Louis Park | Minnesota | 55426 | — |
| University of Missouri-Columbia | Columbia | Missouri | 65203 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130-2042 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89135 | — |
| Hunterdon Hematology Oncology | Flemington | New Jersey | 08822 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | — |
| New York University Cancer Cen | New York | New York | 10016 | — |
| Stony Brook Univ Cancer Ctr | Stony Brook | New York | 11794 | — |
| Messino Cancer Centers | Asheville | North Carolina | 28806 | — |
| Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| Atrium Health Wake Forest Baptist Medical Center - PPDS | Winston-Salem | North Carolina | 27157 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Columbus NCORP | Columbus | Ohio | 43125 | — |
| Stefanie Spielman Comprehensive Breast Center | Columbus | Ohio | 43212 | — |
| Oncology Associates of Oregon, P.C. | Eugene | Oregon | 97401 | — |
| Kaiser Permanente-Northwest Region | Portland | Oregon | 97227 | — |
| Pinnacle Health | Harrisburg | Pennsylvania | 17109 | — |
| Penn State Univ. Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Allegheny Cancer Center | Pittsburgh | Pennsylvania | 15212-4737 | — |
| Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Women & Infants Hospital | Providence | Rhode Island | 02905 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| West Cancer Center & Research Institute | Germantown | Tennessee | 38138-1762 | — |
| Sarah Cannon Research Institute / Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology (Grandview) - USOR | El Paso | Texas | 79902-5113 | — |
| Texas Oncology (Flower Mound) - USOR | Flower Mound | Texas | 75028 | — |
| Texas Oncology-Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Baylor College of Medicine Medical Center | Houston | Texas | 77030 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| Joe Arrington Cancer Research & Treatment Center | Lubbock | Texas | 79410 | — |
| Texas Oncology (McAllen) - USOR | McAllen | Texas | 78503 | — |
| USOR - Texas Oncology - San Antonio Northeast | San Antonio | Texas | 78217 | — |
| Texas Oncology (Tyler) - USOR | Tyler | Texas | 75702-8363 | — |
| Texas Oncology (Waco) - USOR | Waco | Texas | 76712 | — |
| Centra Alan B. Pearson Regional Cancer Center | Lynchburg | Virginia | 24501 | — |
| Bon Secours Mercy Health | Midlothian | Virginia | 23114 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Commonwealth University - Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Oncology and Hematology Associates of Southwest Virginia, Inc.,-Blacksburg | Roanoke | Virginia | 24014 | — |
| Swedish Cancer Institute | Seattle | Washington | 98104 | — |
| West Virginia University Hospitals Inc | Morgantown | West Virginia | 26056 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 549 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04961996, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2026 · Synced Oct 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04961996 live on ClinicalTrials.gov.