A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
Public ClinicalTrials.gov record NCT04975308. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EMBER-3: A Phase 3, Randomized, Open-Label Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Patients With Estrogen Receptor Positive, HER2 Negative Locally Advanced or Metastatic Breast Cancer Previously Treated With Endocrine Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy, and how well imlunestrant with abemaciclib work compared to imlunestrant in participants with breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have breast cancer that is advanced or has spread to another part of the body. Study participation could last up to 5 years.
Study identification
- NCT ID
- NCT04975308
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 874 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 4, 2021 (Actual)
- Primary completion
- Jun 24, 2024 (Actual)
- Completion
- Aug 2027 (Estimated)
- Last update posted
- Jul 22, 2026
2021 – 2027
United States locations
- U.S. sites
- 48
- U.S. states
- 18
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Marin Cancer Care | Greenbrae | California | 94904 | — |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Sharp Memorial Hospital | San Diego | California | 92123 | — |
| Banner MD Anderson Cancer Center at McKee Medical Center | Loveland | Colorado | 80538 | — |
| Clermont Oncology Center | Clermont | Florida | 34711 | — |
| University of Florida College of Medicine | Gainesville | Florida | 32610 | — |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Kaiser Permanente Moanalua Medical Center | Honolulu | Hawaii | 96819 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| NorthShore University HealthSystem - Evanston Hospital | Evanston | Illinois | 60201 | — |
| IU Health Ball Memorial Hospital, Inc. | Muncie | Indiana | 47303 | — |
| The University of Louisville, James Graham Brown Cancer Center | Louisville | Kentucky | 40202 | — |
| Jackson Oncology Associates, PLLC | Jackson | Mississippi | 39202 | — |
| Care Access - Clifton | Clifton | New Jersey | 07013 | — |
| Memorial Sloan Kettering - Bergen | Montvale | New Jersey | 07645 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27599 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Mercy Health - St. Vincent Medical Center | Toledo | Ohio | 43608 | — |
| Avera Cancer Institute Sioux Falls | Sioux Falls | South Dakota | 57105 | — |
| Florida Cancer Specialists | Nashville | Tennessee | 37203 | — |
| The Mark H Zangmeister Cancer Center | Nashville | Tennessee | 37203 | — |
| USO - Texas Oncology - Allen | Allen | Texas | 75013 | — |
| Texas Oncology - Dallas Presbyterian Hospital | Dallas | Texas | 75231 | — |
| Willamette Valley Cancer Institute & Research Ctr. | Houston | Texas | 77070 | — |
| Texas Oncology - Carrollton | Lewisville | Texas | 75056 | — |
| Texas Oncology - Denison | The Woodlands | Texas | 75020 | — |
| Texas Oncology - Paris | The Woodlands | Texas | 75460 | — |
| Blue Ridge Cancer Care | The Woodlands | Texas | 77380 | — |
| Broome Oncology | The Woodlands | Texas | 77380 | — |
| Minnesota Oncology/Hematology PA | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Carrollton | The Woodlands | Texas | 77380 | — |
| Texas Oncology - McKinney | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Medical City Dallas | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Methodist Charlton Cancer Center | The Woodlands | Texas | 77380 | — |
| Texas Oncology - San Antonio Medical Center | The Woodlands | Texas | 77380 | — |
| Texas Oncology - The Woodlands | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Willowbrook | The Woodlands | Texas | 77380 | — |
| Texas Oncology Fort Worth | The Woodlands | Texas | 77380 | — |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | The Woodlands | Texas | 77380 | — |
| USO-Rocky Mountain Cancer Center | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Austin Central | The Woodlands | Texas | 78731 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| The University of Vermont Medical Center Inc. | Burlington | Vermont | 05401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 195 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04975308, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04975308 live on ClinicalTrials.gov.