Study to Evaluate the Efficacy and Safety of AZD4831 in Participants With Heart Failure With Left Ventricular Ejection Fraction > 40%
Public ClinicalTrials.gov record NCT04986202. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Randomised, Double-blind, Placebo-controlled, Multi-center Sequential Phase 2b and Phase 3 Study to Evaluate the Efficacy and Safety of AZD4831 Administered for Up to 48 Weeks in Participants With Heart Failure With Left Ventricular Ejection Fraction > 40%
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomised, double-blind, placebo-controlled, multi-center sequential phase 2b and Phase 3 study to evaluate the efficacy and safety of AZD4831 administered for up to 48 Weeks in participants with heart failure with left ventricular ejection fraction \> 40%. The study will consist of 2 separate parts, Part A and Part B, approximately 660 participants will be randomised in Part A, 820 in Part B.
Study identification
- NCT ID
- NCT04986202
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 711 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 40 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2021 (Actual)
- Primary completion
- Mar 27, 2024 (Actual)
- Completion
- Mar 27, 2024 (Actual)
- Last update posted
- Aug 27, 2025
2021 – 2024
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Alexander City | Alabama | 35010 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Sacramento | California | 95821 | — |
| Research Site | Miami | Florida | 33144 | — |
| Research Site | Miami Beach | Florida | 33140 | — |
| Research Site | Ocala | Florida | 34471 | — |
| Research Site | Evanston | Illinois | 60208 | — |
| Research Site | Hazel Crest | Illinois | 60429 | — |
| Research Site | Shreveport | Louisiana | 71105 | — |
| Research Site | Baltimore | Maryland | 21229 | — |
| Research Site | St Louis | Missouri | 63136 | — |
| Research Site | Buffalo | New York | 14215 | — |
| Research Site | New York | New York | 10019 | — |
| Research Site | Rosedale | New York | 11422 | — |
| Research Site | Chapel Hill | North Carolina | 27599 | — |
| Research Site | Pinehurst | North Carolina | 28374 | — |
| Research Site | Cleveland | Ohio | 44195 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Knoxville | Tennessee | 37916 | — |
| Research Site | Tullahoma | Tennessee | 37388 | — |
| Research Site | Norfolk | Virginia | 23510 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 150 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04986202, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2025 · Synced Nov 7, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04986202 live on ClinicalTrials.gov.