Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma
Public ClinicalTrials.gov record NCT04987203. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TiNivo-2: A Phase 3, Randomized, Controlled, Multicenter, Open-label Study to Compare Tivozanib in Combination With Nivolumab to Tivozanib Monotherapy in Subjects With Renal Cell Carcinoma Who Have Progressed Following One or Two Lines of Therapy Where One Line Has an Immune Checkpoint Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will be comparing tivozanib in combination with nivolumab to tivozanib alone in subjects with advanced Renal Cell Carcinoma (RCC) who have had 1 or 2 prior lines of therapy, one of which was an Immune Checkpoint Inhibitor (ICI).
Study identification
- NCT ID
- NCT04987203
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 343 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 8, 2021
- Primary completion
- Jan 19, 2026
- Completion
- Jan 19, 2026
- Last update posted
- May 7, 2026
2021 – 2026
United States locations
- U.S. sites
- 36
- U.S. states
- 20
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Chao Family Comprehensive Cancer Center, UC Irvine | Irvine | California | 92868 | — |
| University of California San Diego | La Jolla | California | 92037 | — |
| Leland Stanford Junior University | Redwood City | California | 94063 | — |
| Kaiser Permanente Riverside Medical Center | Riverside | California | 92505 | — |
| US Oncology - Rocky Mountain Cancer Centers - Midtown | Denver | Colorado | 80218-1237 | — |
| Florida Cancer Specialists & Res Inst | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists & Research Institute (FCS) - Tampa Cancer Center Location | St. Petersburg | Florida | 33705 | — |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205-2005 | — |
| University of Kentucky UK Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Tulane Cancer Center Clinic - Oncology | New Orleans | Louisiana | 70112 | — |
| University of Maryland Medical Center-Greenebaum Cancer Ctr | Baltimore | Maryland | 21201 | — |
| John Hopkins Medicine - Hematology/oncology | Baltimore | Maryland | 21287 | — |
| Maryland Oncology Hematology | Clinton | Maryland | 20735 | — |
| Dana-Farber Cancer Institute - Medicine | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102-6746 | — |
| Oncology Hematology West PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| Memorial Sloan Kettering Cancer Center - Monmouth - Oncology | Middletown | New Jersey | 07748-3052 | — |
| University of New Mexico - Comprehensive Cancer Center | Albuquerque | New Mexico | 87131-0001 | — |
| Roswell - Roswell Park Cancer Institute - Medical Oncology | Buffalo | New York | 14263 | — |
| Memorial Sloan Kettering Cancer Center - Westchester | East White Plains | New York | 10604 | — |
| Memorial Sloan Kettering Cancer Center (MSKCC) - Memorial Hospital | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center - Nassau | Uniondale | New York | 11553 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195-0001 | — |
| Lehigh Valley Physician Group | Allentown | Pennsylvania | 18103-6218 | — |
| Allegheny General Hospital (AGH) | Pittsburgh | Pennsylvania | 15212-4756 | — |
| UH Cleveland Medical Center | Columbia | South Carolina | 29210 | — |
| Chattanooga Oncology and Hematology Associates | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Texas Oncology - Central Austin Cancer Center | Austin | Texas | 78731 | — |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| US Oncology Texas Oncology (CCC of South Texas) - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| University Of Washington - Medical Center | Seattle | Washington | 98109 | — |
| Northwest Medical Specialties PLLC | Tacoma | Washington | 98405-5016 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 103 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04987203, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04987203 live on ClinicalTrials.gov.