A Proof-of-concept Study of the Efficacy and Safety of Nipocalimab in Participants With Active Rheumatoid Arthritis
Public ClinicalTrials.gov record NCT04991753. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled, Proof-of-concept Study Evaluating the Efficacy and Safety of Nipocalimab Administered Intravenously in Participants With Active Rheumatoid Arthritis Despite Standard Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of nipocalimab versus placebo in participants with moderate to severe active rheumatoid arthritis (RA).
Study identification
- NCT ID
- NCT04991753
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 53 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 13, 2021
- Primary completion
- Aug 9, 2022
- Completion
- Aug 9, 2022
- Last update posted
- Aug 21, 2025
2021 – 2022
United States locations
- U.S. sites
- 13
- U.S. states
- 7
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arthritis & Rheumatology Associates PC | Glendale | Arizona | 85306 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Mesa | Arizona | 85210 | — |
| Arizona Arthritis & Rheumatology Research, PLLC | Tucson | Arizona | 85704 | — |
| Desert Medical Advances | Palm Desert | California | 92260 | — |
| Arthritis Care and Research Center Inc.: Smitha Reddy, MD | Poway | California | 92064 | — |
| TriWest Research Associates, LLC | San Diego | California | 92108 | — |
| Inland Rheumatology Clinical Trials, Inc. | Upland | California | 91786 | — |
| DJL Clinical Research, PLLC | Charlotte | North Carolina | 28210 | — |
| STAT Research, Inc. | Vandalia | Ohio | 45377 | — |
| Low Country Rheumatology PA | Summerville | South Carolina | 29486 | — |
| West Tennessee Research Institute | Jackson | Tennessee | 38305 | — |
| Accurate Clinical Research, Inc. | Houston | Texas | 77089 | — |
| Southwest Rheumatology Research LLC | Mesquite | Texas | 75150 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04991753, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2025 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04991753 live on ClinicalTrials.gov.