A Phase 2a Study of TPN-101 in Patients With Progressive Supranuclear Palsy (PSP)
Public ClinicalTrials.gov record NCT04993768. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2a study to assess the safety and tolerability of TPN-101 patients with PSP.
Study identification
- NCT ID
- NCT04993768
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 42 participants
Conditions and interventions
Conditions
Interventions
- TPN-101, 100 mg/day Drug
- TPN-101, 200 mg/day Drug
- TPN-101, 400 mg/day Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 41 Years to 86 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 12, 2021 (Actual)
- Primary completion
- Feb 24, 2024 (Actual)
- Completion
- Mar 24, 2024 (Actual)
- Last update posted
- Apr 8, 2026
2021 – 2024
United States locations
- U.S. sites
- 14
- U.S. states
- 12
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Joseph's Hospital and Medical Center, Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| UC San Diego Altman Clinical And Translational Research Institute | La Jolla | California | 92037 | — |
| UCSF Neurosciences Clinical Research Unit (NCRU) | San Francisco | California | 94158 | — |
| Rocky Mountain Movement Disorders Center | Englewood | Colorado | 80113 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | — |
| UFHealth Fixel Institute for Neurological Diseases | Gainesville | Florida | 32608 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Irving Center for Clinical and Translational Research | New York | New York | 10032 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04993768, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 8, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04993768 live on ClinicalTrials.gov.