A Study of Danicopan in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration
Public ClinicalTrials.gov record NCT05019521. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Double-Masked, Placebo-Controlled, Dose Range Finding Study of Danicopan (ALXN2040) in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a dose finding study designed to evaluate the efficacy, safety, and pharmacokinetics of danicopan in participants with GA secondary to AMD. The study consists of a Screening Period of up to 6 weeks, a 104-week masked Treatment Period, followed by a 30-day Follow-up after the last dose. This study will have 4 treatments arms: 100 milligrams (mg) twice daily (bid), 200 mg bid, 400 mg once daily (qd), and matching placebo.
Study identification
- NCT ID
- NCT05019521
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 365 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 23, 2021 (Actual)
- Primary completion
- Jul 5, 2024 (Actual)
- Completion
- Jan 21, 2025 (Actual)
- Last update posted
- Sep 5, 2025
2021 – 2025
United States locations
- U.S. sites
- 49
- U.S. states
- 22
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Phoenix | Arizona | 85020 | — |
| Research Site | Beverly Hills | California | 90211 | — |
| Research Site | Encino | California | 91436 | — |
| Research Site | Fresno | California | 93720 | — |
| Research Site | Fullerton | California | 92835 | — |
| Research Site | La Jolla | California | 92093 | — |
| Research Site | Pasadena | California | 91105 | — |
| Research Site | Sacramento | California | 95841 | — |
| Research Site | San Mateo | California | 94401 | — |
| Research Site | Walnut Creek | California | 94598 | — |
| Research Site | Colorado Springs | Colorado | 80909 | — |
| Research Site | Longmont | Colorado | 80503 | — |
| Research Site | Waterford | Connecticut | 06385 | — |
| Research Site | Clearwater | Florida | 33761 | — |
| Research Site | Coral Springs | Florida | 33067 | — |
| Research Site | Deerfield Beach | Florida | 33064 | — |
| Research Site | Naples | Florida | 34103 | — |
| Research Site | Palm Beach Gardens | Florida | 33418 | — |
| Research Site | St. Petersburg | Florida | 33711 | — |
| Research Site | Augusta | Georgia | 30909 | — |
| Research Site | New Albany | Indiana | 47150 | — |
| Research Site | West Des Moines | Iowa | 50266 | — |
| Research Site | Hagerstown | Maryland | 21740 | — |
| Research Site | Rosedale | Maryland | 21237 | — |
| Research Site | Towson | Maryland | 21204 | — |
| Research Site | Springfield | Massachusetts | 01107 | — |
| Research Site | Southaven | Mississippi | 38671 | — |
| Research Site | Reno | Nevada | 89502 | — |
| Research Site | Teaneck | New Jersey | 07666 | — |
| Research Site | Great Neck | New York | 11021 | — |
| Research Site | Durham | North Carolina | 27705 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Portland | Oregon | 97225 | — |
| Research Site | Springfield | Oregon | 97477 | — |
| Research Site | Kingston | Pennsylvania | 18704 | — |
| Research Site | Monroeville | Pennsylvania | 15146 | — |
| Research Site | Philadelphia | Pennsylvania | 19104-2640 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Greenville | South Carolina | 29605 | — |
| Research Site | Ladson | South Carolina | 29456 | — |
| Research Site | Rapid City | South Dakota | 57701 | — |
| Research Site | Austin | Texas | 78750 | — |
| Research Site | Bellaire | Texas | 77401 | — |
| Research Site | Conroe | Texas | 77384 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | San Antonio | Texas | 78240 | — |
| Research Site | Southlake | Texas | 76092 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Lynchburg | Virginia | 24502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 79 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05019521, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 5, 2025 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05019521 live on ClinicalTrials.gov.