ClinicalTrials.gov record
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
ClinicalTrials.gov ID: NCT05021835
Public ClinicalTrials.gov record NCT05021835. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:26 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation
Study identification
- NCT ID
- NCT05021835
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 6,200 participants
Conditions and interventions
Interventions
- Placebo (Ziltivekimab B) Drug
- Placebo (Ziltivekimab C) Drug
- Ziltivekimab B Drug
- Ziltivekimab C Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 29, 2021
- Primary completion
- Jun 8, 2026
- Completion
- Jun 8, 2026
- Last update posted
- Apr 12, 2026
2021 – 2026
United States locations
- U.S. sites
- 181
- U.S. states
- 37
- U.S. cities
- 143
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Chambliss Clinical Trials LLC | Montgomery | Alabama | 36106 | — |
| Lenzmeier Fam Med CCT Research | Glendale | Arizona | 85308 | — |
| Aventiv Research Inc. | Mesa | Arizona | 85206 | — |
| Univ of Arkansas Med Sciences | Little Rock | Arkansas | 72205 | — |
| Unity Health-Searcy Medical Center | Searcy | Arkansas | 72143 | — |
| National Heart Institute Cal | Beverly Hills | California | 90211 | — |
| California Inst Of Renal Res | Chula Vista | California | 91910 | — |
| California Institute of Renal Research #10 | Chula Vista | California | 91910 | — |
| Valley Clinical Trials | Covina | California | 91723 | — |
| Valiance Clinical Research | Huntington Park | California | 90255 | — |
| Scripps Wht Diab Inst La Jolla | La Jolla | California | 92037 | — |
| Balboa Nephro Med Gr Inc LaMes | La Mesa | California | 91942 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| VA Loma Linda Hlthcr Sys | Loma Linda | California | 92357 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Angel City Research, Inc. | Los Angeles | California | 90010 | — |
| North America Research Institute | Lynwood | California | 90262 | — |
| Hoag Medical Group | Newport Beach | California | 92663 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Riverside Nephrology Physicians | Riverside | California | 92503 | — |
| N America Res Inst - San Dimas | San Dimas | California | 91773 | — |
| Lundquist Inst-Biomed Innovtn | Torrance | California | 90502 | — |
| Denver Health Outpatient Medical Center | Denver | Colorado | 80204 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| VA-Connecticut (VACHS) | West Haven | Connecticut | 06516 | — |
| George Washington Uni Med | Washington D.C. | District of Columbia | 20037 | — |
| Excel Med Ctr Clinical Trials | Boca Raton | Florida | 33434 | — |
| Innovative Research of W FL | Clearwater | Florida | 33756 | — |
| Florida Premier Cardiology | Delray Beach | Florida | 33445 | — |
| Northeast Research Institute | Fleming Island | Florida | 32003 | — |
| Integrative Research Assoc Inc | Fort Lauderdale | Florida | 33312 | — |
| Elixia Pines | Hollywood | Florida | 33024 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| Northeast Research Institute | Jacksonville | Florida | 32204 | — |
| Est Cst Inst for Rsrch,Jksnvil | Jacksonville | Florida | 32216 | — |
| Baptist Heart Specialists | Jacksonville | Florida | 32258 | — |
| Clinical Research of Cent FL | Lakeland | Florida | 33805 | — |
| Pharmax Research Clinic | Miami | Florida | 33126 | — |
| Life Spring Research Foundation LLC | Miami | Florida | 33130 | — |
| Allied Biomedical Research | Miami | Florida | 33155 | — |
| San Marcus Res Clin Miami Lakes | Miami Lakes | Florida | 33014 | — |
| Office of Kenneth Blaze DO | Miramar | Florida | 33027 | — |
| Suncoast Clin Res Port Richey | New Port Richey | Florida | 34652 | — |
| Suncoast Clinical Research, Inc. | Palm Harbor | Florida | 34684 | — |
| A&R Research Group, LLC | Pembroke Pines | Florida | 33024 | — |
| Hanson Clinical Research Center | Port Charlotte | Florida | 33952 | — |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | — |
| Northeast Research Institute | Saint Augustine | Florida | 32080 | — |
| East Coast Institute for Research LLC_St. Augustine | Saint Augustine | Florida | 32086 | — |
| St Johns Center for Clin. Res | Saint Augustine | Florida | 32086 | — |
| Javara/Privia Med Grp GA,LLC | Albany | Georgia | 31707 | — |
| Southeastern Clinical R.I. | Augusta | Georgia | 30904 | — |
| Southeastern Clinical Research Institute, LLC | Augusta | Georgia | 30904 | — |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | — |
| Javara Inc._Albany | Fayetteville | Georgia | 30214 | — |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| Javara Inc._Winston Salem | Savannah | Georgia | 31406 | — |
| Saltzer Medical Group Research | Nampa | Idaho | 83686-6011 | — |
| Endeavor Health Clinical Operations-NCH | Arlington Heights | Illinois | 60005 | — |
| Research by Design LLC | Chicago | Illinois | 60643 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Central Illinois Diabetes and Clinical Research | Springfield | Illinois | 62711 | — |
| Clin Invest Spec, Inc | Wauconda | Illinois | 60084 | — |
| MediSphere Medical RC | Evansville | Indiana | 47714 | — |
| Velocity Clin. Res Valparaiso | Valparaiso | Indiana | 46383 | — |
| Midwest Heart & Vasc Spec | Overland Park | Kansas | 66211 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| Lexington VA Health Care System | Lexington | Kentucky | 40502 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| Norton Heart Specialists-Springs | Louisville | Kentucky | 40205 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Clinical Trials of Ame, LLC | Monroe | Louisiana | 71201 | — |
| IMA Clinical Research | Monroe | Louisiana | 71201 | — |
| Grace Research, LLC_Shreveport | Shreveport | Louisiana | 71105 | — |
| Louisiana Heart Center_Slidell | Slidell | Louisiana | 70458 | — |
| Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Suburban Hospital | Bethesda | Maryland | 20814 | — |
| John P Hakim MD and Associates | Clinton | Maryland | 20735 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115-5804 | — |
| Pentucket Medical Associates | Haverhill | Massachusetts | 01830 | — |
| Henry Ford Hospital_Detroit | Detroit | Michigan | 48202 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| McLaren Northern MI Hosp | Petoskey | Michigan | 49770 | — |
| AHS dba Abbot NW Hosp Diab Cen | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota_Minneapolis_1 | Minneapolis | Minnesota | 55455 | — |
| Clinical Research Consultants, LLC | Kansas City | Missouri | 64111 | — |
| Gateway CV Research Cntr Inc. | St Louis | Missouri | 63128 | — |
| St Louis Heart & Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Nebraska Heart Institute_Lincoln | Lincoln | Nebraska | 68526 | — |
| VA NEB - Western IA Health Stm | Omaha | Nebraska | 68105 | — |
| Methodist Phys Clin Heart Cons | Omaha | Nebraska | 68114 | — |
| Univ of Nebraska Medical CTR | Omaha | Nebraska | 68198-3020 | — |
| University of Nevada School of Medicine | Las Vegas | Nevada | 89102 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | — |
| Advanced Heart Care LLC | Bridgewater | New Jersey | 08807-3064 | — |
| Uni of New Mexico-Clinical | Albuquerque | New Mexico | 87106 | — |
| NYU Nephrology Associates | Mineola | New York | 11501 | — |
| NYU Grossman School of Med | New York | New York | 10016 | — |
| Mount Sinai Hosp at NYC | New York | New York | 10019 | — |
| Northport VA Med Ctr Northport | Northport | New York | 11768 | — |
| Mattoo & Bhat M.A. | Ridgewood | New York | 11385 | — |
| Saratoga Clinical Research | Saratoga Springs | New York | 12866 | — |
| DaVita Clinical Research - New York | The Bronx | New York | 10461 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| Mountain Kidney & Hypertension Associates | Asheville | North Carolina | 28801 | — |
| Kernodle Clin Dpt-Pvt Diagnost | Burlington | North Carolina | 27215 | — |
| UNC- Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Metrolina Nephrology Associates, PA | Charlotte | North Carolina | 28208 | — |
| Javara Inc._Charlotte | Charlotte | North Carolina | 28210 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Univ of Cincinnati Med Cent | Cincinnati | Ohio | 45267 | — |
| VA Northeast Ohio Healthcare System (VANEOHS) | Cleveland | Ohio | 44106 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| Northeast Clinical Research Center | Bethlehem | Pennsylvania | 18017 | — |
| Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania | 19114 | — |
| Parkside Family Medicine | Philadelphia | Pennsylvania | 19144 | — |
| Ocean St Clin Res Partnrs, LLC | Lincoln | Rhode Island | 02865 | — |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | — |
| Palmetto Clinical Research | Greenville | South Carolina | 29615 | — |
| Family Medicine of SayeBrook LLC | Myrtle Beach | South Carolina | 29588 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| Balad Hlth Sys-Welmont CardCVA | Greeneville | Tennessee | 37745 | — |
| Tennova HC Turkey Creek MC | Knoxville | Tennessee | 37934 | — |
| Clinical Neuroscience Solutions | Memphis | Tennessee | 38119 | — |
| CV Research of Knoxville | Powell | Tennessee | 37849 | — |
| Liberty Research Center | Arlington | Texas | 76002 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| Novel Research LLC | Bellaire | Texas | 77401 | — |
| Osvaldo A. Brusco MD | Corpus Christi | Texas | 78414 | — |
| Research Trials Worldwide LLC | Cypress | Texas | 77429 | — |
| Renal Disease Research Institute | Dallas | Texas | 75204 | — |
| Thyroid Endocrinology & Diabetes PA | Dallas | Texas | 75208 | — |
| Liberty Research Center_Dallas | Dallas | Texas | 75230 | — |
| DHR Health Inst for Res & Dev | Edinburg | Texas | 78539 | — |
| Academy of Diabetes, T&E | El Paso | Texas | 79935 | — |
| Care United Research, LLC | Forney | Texas | 75126 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| Javara /TX.Hlth LLC dba Prvia | Fort Worth | Texas | 76133 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Baylor College Of Medicine_Houston Travis Street | Houston | Texas | 77030 | — |
| Baylor College Of Medicine_Houston | Houston | Texas | 77030 | — |
| Biopharma Informatic_Houston | Houston | Texas | 77043 | — |
| Prolato Clinical Research Center | Houston | Texas | 77054 | — |
| Prolato Clinical Research Cntr | Houston | Texas | 77054 | — |
| Card Specialists of Willowbrook | Houston | Texas | 77070 | — |
| PlanIt Research, PLLC | Houston | Texas | 77079 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | — |
| Biopharma Informatic_Houston_0 | Houston | Texas | 77090 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Texas Inst, Kdny & Endo Disor | Lufkin | Texas | 75904 | — |
| RGV Endocrine Center | McAllen | Texas | 78503 | — |
| Carlos Arauz-Pacheco Md, Pa | Rockwall | Texas | 75032 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Briggs Clinical Research, LLC | San Antonio | Texas | 78224 | — |
| University Hospital | San Antonio | Texas | 78229 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| Javara Privia Grp Gulf Cst LLC | San Marcos | Texas | 78666 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Hillcrest Family Health Center | Waco | Texas | 76708 | — |
| University of Utah School of Medicine | Salt Lake City | Utah | 84108 | — |
| Javara Inc/Privia Md GpLLC Fst | Forest | Virginia | 24551 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
| Virginia Commonwealth University Health System | Richmond | Virginia | 23298 | — |
| VA Medical Center_Salem | Salem | Virginia | 24153-6404 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
| Marshfield Clinic | Weston | Wisconsin | 54476 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 884 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05021835, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05021835 live on ClinicalTrials.gov.