ClinicalTrials.gov record
A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)
ClinicalTrials.gov ID: NCT05026866
Public ClinicalTrials.gov record NCT05026866. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of Donanemab Versus Placebo in Participants at Risk for Cognitive and Functional Decline of Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to evaluate the safety and efficacy of donanemab in participants with preclinical Alzheimer's Disease (AD) over up to 332 weeks. Approximately 800 additional participants will be enrolled in the 12-month Addendum 7 to assess safety of a different titration regimen.
Study identification
- NCT ID
- NCT05026866
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,996 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 55 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 27, 2021 (Actual)
- Primary completion
- Nov 2027 (Estimated)
- Completion
- Nov 2027 (Estimated)
- Last update posted
- Jan 21, 2026
2021 – 2027
United States locations
- U.S. sites
- 198
- U.S. states
- 38
- U.S. cities
- 166
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Parkway Medical Center | Birmingham | Alabama | 35215 | — |
| Alabama Psychiatry - Birmingham - Brookwood Medical Center Drive | Homewood | Alabama | 35209 | — |
| Rehabilitation & Neurological Services | Huntsville | Alabama | 35805 | — |
| Care Access - 801 South Power Road, Mesa | Mesa | Arizona | 85206 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Banner Alzheimer's Institute Tucson | Tucson | Arizona | 85718 | — |
| Center for Neurosciences | Tucson | Arizona | 85718 | — |
| Care Access - Berkeley | Berkeley | California | 94705 | — |
| Care Access - Beverly Hills | Beverly Hills | California | 90212 | — |
| Velocity Clinical Research, Chula Vista | Chula Vista | California | 91911 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Care Access - Gilroy | Gilroy | California | 95020 | — |
| Marvel Clinical Research | Huntington Beach | California | 92647 | — |
| Care Access Research - Huntington Beach | Huntington Beach | California | 92648 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| Option Care - Irvine | Irvine | California | 92618 | — |
| Kaizen Brain Center | La Jolla | California | 92037 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Pacific Research Network | Lemon Grove | California | 91945 | — |
| Healthy Brain Clinic | Long Beach | California | 90804 | — |
| Neurovations | Napa | California | 94558 | — |
| Care Access - Newport Beach | Newport Beach | California | 92660 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Inland Psychiatric Medical Group | Redlands | California | 92373 | — |
| Anderson Clinical Research | Redlands | California | 92374 | — |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | — |
| Option Care - Riverside | Riverside | California | 92507 | — |
| Clinical Trials Research | Sacramento | California | 95821 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92123 | — |
| Ray Dolby Brain Health Center | San Francisco | California | 94114 | — |
| Care Access - Los Gatos | San Jose | California | 95124 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Care Access - Santa Clarita | Santa Clarita | California | 91321 | — |
| Option Care - Los Angeles South | Santa Fe Springs | California | 90670 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| Mazur, Statner, Dutta, Nathan, PC | Thousand Oaks | California | 91360 | — |
| Tilda Research | Tustin | California | 92780 | — |
| Velocity Clinical Research, Panorama City | Van Nuys | California | 91405 | — |
| Infectious Disease Doctors Medical Group, APC | Walnut Creek | California | 94598 | — |
| Care Access - Aurora | Aurora | Colorado | 80012 | — |
| Mountain Neurological Research Center | Basalt | Colorado | 81621 | — |
| Denver Neurological Research | Denver | Colorado | 80210 | — |
| Invicro | New Haven | Connecticut | 06510 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| VIN-Julie Schwartzbard | Aventura | Florida | 33180 | — |
| Neurology Offices of South Florida | Boca Raton | Florida | 33428 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| SFM Clinical Research | Boca Raton | Florida | 33487 | — |
| Bradenton Research Center, Inc. | Bradenton | Florida | 34205 | — |
| Clinical Research of West Florida, Inc. (Clearwater) | Clearwater | Florida | 33765 | — |
| Care Access - Daytona Beach | Daytona Beach | Florida | 32114 | — |
| Care Access - Delray Beach | Delray Beach | Florida | 33484 | — |
| Finlay Medical Research | Greenacres City | Florida | 33467 | — |
| Indago Research & Health Center, Inc | Hialeah | Florida | 33012 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33024 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Care Access - Guava Street | Lady Lake | Florida | 32159 | — |
| Accel Research Sites - St. Pete-Largo Clinical Research Unit | Largo | Florida | 33777 | — |
| ClinCloud - Maitland | Maitland | Florida | 32751 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| ClinCloud - Viera | Melbourne | Florida | 32940 | — |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | — |
| Optimus U Corporation | Miami | Florida | 33125 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| VIN-Andrew Lerman | Miami | Florida | 33133 | — |
| South Florida Research Phase I-IV | Miami | Florida | 33166 | — |
| Brainstorm Research Group | Miami | Florida | 33176 | — |
| IMIC, Inc. | Miami | Florida | 33176 | — |
| VIN-Victor Faradji | Miami | Florida | 33176 | — |
| San Marcus Research Clinic, Inc. | Miami Lakes | Florida | 33014 | — |
| Adult Medicine of Lake County | Mt. Dora | Florida | 32757 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Charter Research - Winter Park | Orlando | Florida | 32803 | — |
| Headlands Research Orlando | Orlando | Florida | 32806 | — |
| Pines Care Research Center, LLC | Pembroke Pines | Florida | 33024 | — |
| VIN- Margarita Almeida El-Ramey | Pembroke Pines | Florida | 33026 | — |
| Emerald Coast Neurology - Airport Boulevard | Pensacola | Florida | 32504 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Care Access - Tamarac | Tamarac | Florida | 33321 | — |
| Clinical Research of West Florida | Tampa | Florida | 33606 | — |
| Stedman Clinical Trials | Tampa | Florida | 33613 | — |
| Vicis Clinical Research | Tampa | Florida | 33615 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| Coram CVS/Specialty Infusion Services - Tampa | Tampa | Florida | 33634 | — |
| K2 Medical Research - Tampa | Tampa | Florida | 33634 | — |
| Charter Research - Lady Lake | The Villages | Florida | 32162 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Masters of Clinical Research | Augusta | Georgia | 30909 | — |
| iResearch Atlanta | Decatur | Georgia | 30030 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| Meridian Clinical Research, LLC | Savannah | Georgia | 31406 | — |
| SKY Clinical Research Network Group-Blake | Union City | Georgia | 30291 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Northwest Clinical Trials | Boise | Idaho | 83704 | — |
| IMA Clinical Research Chicago | Chicago | Illinois | 60602 | — |
| Great Lakes Clinical Trials - Andersonville | Chicago | Illinois | 60640 | — |
| Uptown Research Institute | Chicago | Illinois | 60640 | — |
| AMITA Health - Alexian Brothers Neurosciences Institute Clinical Research | Elk Grove Village | Illinois | 60007 | — |
| Care Access - Fairview Heights | Fairview Heights | Illinois | 62208 | — |
| Great Lakes Clinical Trials - Gurnee | Gurnee | Illinois | 60031 | — |
| Accellacare - DuPage | Lombard | Illinois | 60148 | — |
| Coram CVS/Specialty Infusion Services - Fort Wayne | Fort Wayne | Indiana | 46805 | — |
| Care Access - South Indianapolis | Indianapolis | Indiana | 46227 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| Covenant Medical Center | Waterloo | Iowa | 50702 | — |
| College Park Specialty Center | Overland Park | Kansas | 66212 | — |
| Norton Brownsboro Hospital | Louisville | Kentucky | 40241 | — |
| Optum Infusion - Baton Rouge | Baton Rouge | Louisiana | 70809 | — |
| Care Access - Lake Charles | Lake Charles | Louisiana | 70601 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Care Access - Quincy | Quincy | Massachusetts | 02169 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| Revival Research Institute | Southfield | Michigan | 48075 | — |
| Minneapolis Clinic of Neurology - Burnsville Office | Burnsville | Minnesota | 55337 | — |
| Coram CVS/Specialty Infusion Services - Mendota Heights | Mendota Heights | Minnesota | 55120 | — |
| SKY Clinical Research Network Group - Hall | Fayette | Mississippi | 39069 | — |
| SKY Clinical Research Network Group-Quinn | Ridgeland | Mississippi | 39157 | — |
| Citizens Memorial Hospital District | Bolivar | Missouri | 65613 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| IMA Clinical Research - St. Louis | St Louis | Missouri | 63117 | — |
| Coram CVS/Specialty Infusion Services - Henderson | Henderson | Nevada | 89014 | — |
| Option Care - Las Vegas | Las Vegas | Nevada | 89102 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89128 | — |
| IMA Clinical Research Hoboken | Hoboken | New Jersey | 07030 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| IMA Clinical Research Warren | Warren Township | New Jersey | 07059 | — |
| Albuquerque Neuroscience Inc. | Albuquerque | New Mexico | 87109 | — |
| IMA Clinical Research Albany | Albany | New York | 12205 | — |
| Neurological Associates Albany | Albany | New York | 12208 | — |
| Velocity Clinical Research, Syracuse | East Syracuse | New York | 13057 | — |
| IMA Clinical Research Westchester | Hartsdale | New York | 10530 | — |
| IMA Clinical Research | New York | New York | 10036 | — |
| South Shore Neurologic Associates | Patchogue | New York | 11772 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| Prime Global Research | The Bronx | New York | 10456 | — |
| Asheville Neurology Specialists | Asheville | North Carolina | 28806 | — |
| Care Access - Charlotte | Charlotte | North Carolina | 28210 | — |
| Care Access - Fayetteville | Fayetteville | North Carolina | 28314 | — |
| Care Access - Greensboro | Greensboro | North Carolina | 27401 | — |
| Medication Management | Greensboro | North Carolina | 27405 | — |
| Care Access - Kinston | Kinston | North Carolina | 28501 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Care Access - Raleigh | Raleigh | North Carolina | 27607 | — |
| Accellacare - Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| NeuroScience Research Center | Canton | Ohio | 44718 | — |
| Hometown Urgent Care and Research - Cincinnati | Dayton | Ohio | 45424 | — |
| Neurology Diagnostics, Inc. | Dayton | Ohio | 45459 | — |
| Care Access - Lima | Lima | Ohio | 45805 | — |
| North Star Medical Research | Middleburg Heights | Ohio | 44130 | — |
| Care Access - Youngstown | Poland | Ohio | 44514 | — |
| Central States Research | Tulsa | Oklahoma | 74136 | — |
| Optum Infusion - Bend | Bend | Oregon | 97701 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Center for Cognitive Health | Portland | Oregon | 97225 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Care Access - Pottsville | Pottsville | Pennsylvania | 17901 | — |
| Care Access Research - Warwick | Warwick | Rhode Island | 02886 | — |
| Care Access - Anderson | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research, Anderson | Anderson | South Carolina | 29621 | — |
| VitaLink Research - Columbia | Columbia | South Carolina | 29204 | — |
| Velocity Clinical Research, Gaffney | Gaffney | South Carolina | 29340 | — |
| VitaLink Research - Greenville | Greenville | South Carolina | 29615 | — |
| Care Access - Mauldin | Mauldin | South Carolina | 29662 | — |
| VitaLink Research - Spartanburg | Spartanburg | South Carolina | 29303 | — |
| VitaLink Research - Union | Union | South Carolina | 29379 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Neurology Clinic | Cordova | Tennessee | 38018 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Memphis | Tennessee | 38119 | — |
| Texas Diabetes & Endocrinology, P.A. | Austin | Texas | 78749 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Gadolin Research | Beaumont | Texas | 77702 | — |
| Headlands Research - Brownsville | Brownsville | Texas | 78526 | — |
| Conroe Willis Medical Research | Conroe | Texas | 77304 | — |
| Advanced Neuro Research Center - ANRC | El Paso | Texas | 79912 | — |
| Care Access - Georgetown | Georgetown | Texas | 78633 | — |
| Optum Infusion - Houston | Houston | Texas | 77054 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77054 | — |
| Next Level Urgent Care | Houston | Texas | 77057 | — |
| Family Practice Center | McAllen | Texas | 78501 | — |
| El Faro Health and Therapeutics | Rio Grande City | Texas | 78582 | — |
| Benchmark Research - Knickerbocker | San Angelo | Texas | 76904 | — |
| Diagnostics Research Group | San Antonio | Texas | 78229 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Texas Valley Clinical Research | Weslaco | Texas | 78596 | — |
| The Memory Clinic | Bennington | Vermont | 05201-9810 | — |
| Care Access - Arlington | Arlington | Virginia | 22206 | — |
| Option Care - Chantilly | Chantilly | Virginia | 20151 | — |
| Dominion Medical Associates, Inc. | Richmond | Virginia | 23219 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Universal Research Group | Tacoma | Washington | 98405 | — |
| Optum Infusion - Woodinville | Woodinville | Washington | 98072 | — |
| Exemplar Research | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 18 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05026866, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05026866 live on ClinicalTrials.gov.