A Study of Zanidatamab (ZW25) With Evorpacept (ALX148) in Patients With Advanced HER2-expressing Cancer
Public ClinicalTrials.gov record NCT05027139. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1b/2, 2-part Open-label Study to Assess the Safety and Antitumor Activity of Zanidatamab in Combination With ALX148 in Advanced HER2-expressing Cancer
Study identification
- NCT ID
- NCT05027139
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Jazz Pharmaceuticals
- Industry
- Enrollment
- 52 participants
Conditions and interventions
Conditions
Interventions
- Evorpacept Drug
- Zanidatamab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 14, 2021
- Primary completion
- Jul 6, 2025
- Completion
- Sep 29, 2025
- Last update posted
- Oct 15, 2025
2021 – 2025
United States locations
- U.S. sites
- 11
- U.S. states
- 9
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UC San Diego - Moores Cancer Center | La Jolla | California | 92093 | — |
| UCLA Department of Medicine Hematology/Oncology | Los Angeles | California | 90095 | — |
| UC Irvine Health - Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Magee-Womens Hospital of UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05027139, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2025 · Synced May 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05027139 live on ClinicalTrials.gov.