A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)
Public ClinicalTrials.gov record NCT05035082. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
REALYSE - Comparative Effectiveness of Once-daily Oral Semaglutide Versus Any Other Oral Glucose-lowering Medication in a Real-world Adult Population With Type 2 Diabetes on Metformin Monotherapy in US Based Health Care Systems - a Pragmatic Randomized Trial
Study identification
- NCT ID
- NCT05035082
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 1,020 participants
Conditions and interventions
Conditions
Interventions
- oral glucose-lowering medications (commercially available) Drug
- semaglutide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 31, 2021
- Primary completion
- Jun 17, 2025
- Completion
- Jun 17, 2025
- Last update posted
- Nov 24, 2025
2021 – 2025
United States locations
- U.S. sites
- 25
- U.S. states
- 11
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Stewart Medical Group | Alhambra | California | 91801 | — |
| FDRC | Costa Mesa | California | 92627 | — |
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| Raincross Medical Group | Riverside | California | 92506 | — |
| Reyes Clinical Research, Inc | Miami | Florida | 33175 | — |
| DC Research Works | Marietta | Georgia | 30060 | — |
| Urban Family Practice Assoc | Marietta | Georgia | 30067 | — |
| Macoupin Research Group | Gillespie | Illinois | 62033 | — |
| UnityPoint Health-Diabetes Care Center | Peoria | Illinois | 61603 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Kernodle Clin Dpt-Pvt Diagnost | Burlington | North Carolina | 27215 | — |
| OnSite Clinical Solutions, LLC_Charlotte | Charlotte | North Carolina | 28277 | — |
| WakeMed Garner Hlthplx | Garner | North Carolina | 27529 | — |
| Clinical Research of Gastonia | Gastonia | North Carolina | 28054 | — |
| Valley Weight Loss Clinic | Fargo | North Dakota | 58104 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| Central Ohio Clinical Research LLC | Columbus | Ohio | 43213 | — |
| Jefferson Endocrinology Assocs | Philadelphia | Pennsylvania | 19107-6810 | — |
| Tristar Clin Investigations, PC | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians_Pittsburgh | Pittsburgh | Pennsylvania | 15236 | — |
| AnMed Health IMA | Anderson | South Carolina | 29621 | — |
| Baylor Scott & White Res Inst | Dallas | Texas | 75246 | — |
| Hill Country Medical Associates | New Braunfels | Texas | 78130 | — |
| DCT-Stone Oak | San Antonio | Texas | 78258 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05035082, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 24, 2025 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05035082 live on ClinicalTrials.gov.